| Effector Protein ID: 52842371 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2157 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2416693..2421213 [+] |
| Product | Sid related protein-like |
| Effector type | Protein |
| Descripton | LaiA/SdeA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | An integrin-like protein involved in adhesion to and invasion of human lung alveolar epithelial cells. (Chang et al. 2005) |
| UniProt ID | Q5ZTK4 |
| KEGG ID | lpn:lpg2157 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | SidE [PF12252], Evalue: 0, Aligned region: 8..1446 |
| Protein Sequence: 1506 a.a. [Download] |
| >gi|52842371|ref|YP_096170.1| Sid related protein-like [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MSLGEAIMPKYVEGVELTQEGMHAIFARMGYGDITSGSIYNGVPTIDTGALNRQGFMPVLTGVGPHRDSG HWIMLIKGPGNQYYLFDPLGKTSGEGYQNILAAQLPMGSTLSVIPNGSGLNMGLCGYWVASAGLRAHQAL NQHNPPTLLNVGQTITNEMRNELDHDGYRKITGWLRAVADEFPEGDPQLDGKALRENTEKDLKIEIPTLV LPGKDTSPKEMSVKPTAPQDKSVPVWNGFSLYTDDTVKAAAQYAYDNYLGKPYTGSVESAPANFGGRMVY RQHHGLSHTLRTMAYAELIVEEARKAKLRGETLGKFKDGRTIADVTPQELKKIMIAQAFFVAGRDDEASD AKNYQKYHEQSRDAFLKYVKDNESTLIPDVFKDQEDVNFYARVIEDKSHDWESTPAHVLINQGHMVDLVR VKQPPESFLQRYFSSMQRWIGSQATEAVFGIQRQFFHATYEVVAGFDSDNKEPHLVVSGLGRYVIGEDGQ PIREAPKKGQKEGDLKVFPQTYKLKENERLMRVDEFLKLPEIQNTFPGSGKHLQGGMPGMNEMDYWNRLN SLNRARCENDVDFCLKQLQTAHDKAKIEPIKQAFQSSKGKERRQPNVDEIAAARIIQQILANPDCIHDDH VLINGQKLEQQFFRDLLAKCEMAVVGSLLNDTDIGNIDTLMRHEKDTEFHSTNPEAVPVKIGEYWINDQR INNSSGNITQKKHDLIFLMQNDAWYFSRVNAIAQNRDKGSTFKEVLITTLMTPLTSKALVDTSQAKPPTR LFRGLNLSEEFTKGLIDQANAMIANTTERLFTDHSPEAFKQIKLNDLSKMSGRTNASTTTEIKLVKETWD SNVIFEMLDPDGLLHSKQVGRHGEGTESEFSVYLPEDVALVPVKVTLDGKTQKGENRYVFTFVAVKSPDF TPRHESGYAVEPFLRMQAAKLAEVKSSIEKAQRAPDLETIFNLQNEVEAVQYSHLSTGYKNFLKNTVGPV LENSLSGLMESDTDTLSKALAAFPSDTQWSAFNFEEARQAKRQMDAIKQMVGNKVVLDALTQCQDALEKQ NIAGALDALKKIPSEKEMGTIRRELREQIQSARQELESLQRAVVTPVVTDEKKVRERYDALIENTSKKIT ELETGKLPNLDAVKKGISNLSNLKQEVTVLRNEKIRMHVGTDKVDFSDVEKLEQQIQVIDTKLADAYLLE VTKQISALDNTKPKNQTELKTKIAAFLDRTTDIEMLRNERIKKHGSSKDPLDLSDLDKLSGSLQRINQSL VSDLITTIRVSINQMEAKTFHEQEKEIQQNFELLAKLEKTLDKSKTSEKLREDIPKLNDLLVAKQKAYPQ MVQMQLKSEVFVTQLREVCQANHDDLDKTRNARLRELDRLDREAGITRMVGNLIWGLTNKVGLTTDERLD IRTKQQSLARFKNELFNDKIDTDQLISNLARKRPSELQEGLGISTDNAMELHLLLTELAGKTTSPDELEE RMKAIDDISTKIGREPEHLKFVMVEEDESNKKTIGF |
| - |
| Nucleotide Sequence: 4521 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2416693-2421213 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATCAGTTTGGGAGAAGCCATAATGCCTAAGTATGTCGAAGGGGTAGAACTAACTCAAGAAGGTATGCATG CTATTTTTGCACGCATGGGGTATGGAGATATTACCAGCGGTAGCATATACAACGGAGTGCCAACTATTGA CACAGGTGCGCTAAACAGGCAAGGTTTTATGCCCGTGTTAACCGGGGTAGGACCACACAGAGACTCCGGC CACTGGATTATGTTAATCAAAGGTCCTGGCAACCAATACTACCTCTTTGACCCATTAGGCAAAACATCAG GTGAAGGCTATCAAAATATTTTAGCAGCCCAATTACCAATGGGGTCTACCCTTTCTGTTATTCCCAATGG TTCCGGTTTGAATATGGGATTATGCGGCTACTGGGTCGCCTCTGCTGGTTTAAGAGCACACCAGGCATTA AATCAACATAATCCCCCTACTTTGTTAAATGTGGGACAAACCATTACCAATGAAATGCGTAACGAACTCG ATCATGACGGTTATCGAAAAATTACCGGATGGTTACGTGCTGTTGCTGATGAATTCCCTGAAGGTGACCC ACAATTAGATGGGAAAGCATTAAGAGAAAACACTGAAAAAGATTTAAAAATAGAAATTCCTACACTGGTT CTTCCTGGAAAAGATACCTCCCCTAAAGAAATGTCTGTTAAACCCACTGCACCACAAGATAAATCTGTGC CTGTTTGGAATGGGTTTTCATTATATACTGATGATACCGTTAAAGCCGCGGCACAATACGCCTATGACAA CTATCTGGGCAAACCGTATACCGGATCAGTTGAATCAGCACCTGCGAATTTTGGCGGTCGAATGGTGTAC AGACAACATCATGGACTTTCCCATACTTTACGGACCATGGCTTATGCGGAATTGATTGTTGAAGAAGCAC GTAAAGCTAAATTACGGGGTGAAACATTAGGGAAATTCAAAGACGGACGTACTATTGCTGACGTTACCCC TCAAGAACTAAAAAAAATCATGATTGCCCAGGCATTTTTTGTAGCTGGACGTGATGATGAAGCATCCGAT GCCAAGAACTACCAAAAATATCATGAACAAAGCCGGGATGCTTTCTTAAAATATGTGAAAGACAATGAAT CCACTTTGATTCCTGATGTTTTCAAAGATCAGGAAGATGTCAATTTTTATGCCCGAGTGATTGAAGATAA AAGTCATGATTGGGAATCAACCCCAGCCCATGTGCTAATTAACCAGGGCCATATGGTCGATTTGGTACGG GTCAAGCAACCCCCTGAATCATTCTTACAACGCTATTTCAGTTCCATGCAACGCTGGATAGGTTCACAGG CAACGGAAGCTGTTTTTGGAATACAAAGACAGTTTTTCCATGCTACCTATGAAGTAGTCGCAGGTTTTGA CTCCGATAACAAAGAACCTCATTTGGTTGTTTCTGGTTTAGGTCGTTATGTCATCGGTGAAGATGGTCAA CCTATCCGAGAAGCTCCGAAAAAAGGACAGAAAGAAGGAGATTTAAAAGTTTTCCCTCAAACTTATAAAT TAAAAGAAAATGAGCGTCTTATGCGCGTCGATGAATTTTTAAAACTTCCTGAAATACAAAATACCTTCCC TGGTTCTGGCAAACATTTACAAGGTGGAATGCCAGGTATGAATGAAATGGATTATTGGAATCGACTGAAC TCTTTAAACAGAGCACGATGCGAAAACGATGTTGATTTTTGTTTGAAACAATTACAAACAGCCCATGACA AGGCGAAAATTGAGCCTATTAAACAAGCTTTTCAATCCAGTAAAGGGAAAGAAAGAAGACAACCTAATGT CGATGAAATTGCTGCTGCCCGCATCATTCAGCAAATCTTGGCCAATCCTGATTGCATCCATGATGATCAT GTGCTCATCAATGGCCAGAAACTGGAACAACAATTCTTCCGTGACTTGTTAGCGAAATGCGAGATGGCTG TTGTAGGCTCACTCCTCAATGACACCGACATAGGAAACATTGATACTTTAATGCGACATGAAAAAGACAC TGAGTTTCATTCTACCAATCCTGAAGCAGTTCCGGTGAAAATTGGAGAATATTGGATTAATGACCAAAGA ATTAATAATAGTAGTGGCAACATCACCCAAAAGAAACACGATCTAATTTTCCTCATGCAAAATGATGCGT GGTATTTTAGCCGAGTCAATGCCATCGCCCAAAACCGGGATAAAGGCTCTACTTTCAAGGAGGTGTTGAT TACTACTTTAATGACGCCTTTGACTAGTAAAGCACTAGTGGATACCTCGCAAGCCAAGCCCCCTACAAGA CTATTTCGTGGATTAAACCTGTCAGAAGAGTTTACCAAGGGATTAATTGATCAAGCGAATGCAATGATTG CCAATACGACAGAGCGTCTTTTCACCGATCATTCACCAGAAGCCTTCAAACAAATCAAGTTAAATGATTT AAGTAAAATGTCCGGCAGAACCAATGCCAGTACAACCACGGAGATTAAGCTTGTAAAAGAAACCTGGGAC TCCAATGTCATCTTTGAAATGCTTGACCCGGATGGTTTGCTGCATTCCAAGCAAGTAGGACGCCATGGCG AAGGCACCGAAAGTGAATTCTCCGTTTATTTGCCGGAGGATGTTGCCCTGGTCCCAGTCAAGGTCACCCT TGATGGTAAAACGCAAAAAGGGGAAAATCGATATGTCTTTACCTTTGTTGCCGTAAAAAGCCCTGACTTT ACACCACGTCATGAAAGCGGCTATGCGGTTGAACCGTTTTTAAGAATGCAAGCCGCAAAGTTAGCCGAAG TCAAAAGCTCTATTGAAAAAGCCCAGAGAGCACCTGACCTTGAGACAATTTTCAATTTACAAAACGAAGT AGAAGCAGTGCAATACTCACACTTATCGACGGGTTACAAAAATTTTCTAAAAAACACCGTTGGTCCTGTT TTAGAAAATAGTCTTAGTGGACTCATGGAGAGTGACACGGACACTTTAAGTAAAGCATTAGCAGCATTCC CATCCGATACACAATGGTCAGCCTTCAATTTTGAAGAAGCAAGGCAAGCCAAAAGACAGATGGATGCCAT TAAGCAAATGGTTGGAAATAAAGTGGTGCTTGACGCCTTGACTCAATGCCAGGACGCGCTGGAAAAGCAA AATATCGCTGGCGCACTGGATGCTCTCAAAAAAATCCCGTCCGAAAAAGAGATGGGTACAATTAGAAGAG AGCTAAGAGAACAAATCCAAAGCGCCAGGCAAGAACTGGAATCATTGCAGCGTGCTGTTGTTACCCCTGT AGTAACCGATGAAAAGAAAGTAAGAGAACGCTATGATGCCCTGATAGAAAACACATCGAAGAAAATTACT GAACTTGAAACAGGGAAATTACCCAATCTTGATGCTGTCAAGAAAGGCATATCTAACTTGAGCAACCTGA AACAAGAAGTAACCGTATTACGTAATGAAAAAATACGGATGCACGTTGGAACTGATAAAGTTGATTTTTC AGATGTTGAAAAACTGGAACAACAAATACAGGTTATCGATACCAAATTAGCCGATGCTTATTTACTTGAA GTAACCAAACAAATTTCAGCGCTTGACAATACAAAACCCAAAAATCAGACTGAATTGAAAACAAAAATAG CAGCATTTCTTGACAGAACCACTGATATTGAAATGTTGCGTAATGAGCGAATCAAAAAACACGGTTCATC GAAAGATCCACTGGATCTGTCTGATTTGGATAAATTAAGCGGCAGCTTACAGCGCATTAATCAATCCCTG GTTTCAGATTTGATAACAACCATCCGTGTGTCCATCAATCAAATGGAAGCGAAAACTTTTCACGAACAGG AAAAGGAAATACAACAAAATTTCGAGTTACTCGCAAAACTCGAAAAAACATTGGATAAGTCAAAGACATC AGAAAAACTAAGGGAGGATATTCCCAAACTTAATGATTTGCTGGTTGCAAAACAAAAAGCCTACCCTCAA ATGGTACAAATGCAACTCAAGAGCGAAGTCTTCGTTACCCAATTACGTGAGGTATGTCAAGCTAACCATG ACGATCTGGATAAAACAAGAAATGCAAGATTACGAGAACTGGATCGGCTGGACAGAGAAGCTGGAATAAC AAGAATGGTGGGTAATCTAATCTGGGGTCTTACCAACAAAGTAGGTTTAACCACAGACGAACGACTTGAC ATCAGGACTAAACAGCAATCGCTTGCACGATTCAAAAATGAATTATTTAATGACAAGATTGATACGGATC AGCTAATCTCTAATTTGGCAAGGAAAAGACCTTCTGAACTGCAAGAAGGATTGGGAATATCTACAGACAA TGCGATGGAGTTACATTTACTGTTAACTGAGTTAGCGGGTAAAACAACTTCTCCAGATGAACTGGAAGAA AGAATGAAAGCAATCGATGACATTTCCACCAAGATAGGTAGAGAGCCTGAGCATTTGAAATTTGTCATGG TTGAAGAAGATGAATCCAATAAAAAAACTATAGGATTTTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Bardill JP; Miller JL; Vogel JP (2005). IcmS-dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion system. Mol Microbiol. 56(1):90-103. [PudMed:15773981]
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| experimental literature |
| in silico analysis literature |