| Effector Protein ID: 52842361 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg2147 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2394467..2395915 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | MavC |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZTL4 |
| KEGG ID | lpn:lpg2147 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 482 a.a. [Download] |
| >gi|52842361|ref|YP_096160.1| hypothetical protein lpg2147 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MTTSKLEKTGLHVHEKIKHMVKNYGTMITGIPAEILGQNEAEISVGYVKKMGNMKENIAEVVRKSEMTQP TNSCGKASNEVCDLLLGTEGASEFEKSSYQVLSGDGSNLKGSLPNKNLLVRVEMDRFNAPQKYQKIKREE FNPETAEKNKIYLLEDQLVYLDIFGKVIDLGQTSDTCHRLFNAITTPFYQNYILYDEYIDPEESAEEAAM FEMGEIVKAKMKNIDCWTATHSFTIFVPESDSEDTRTLYPYQAYWTSHTLQQWFSGDKDEKLSRLGIDGY IEKLALLGTTTDSKIRSSIYGELFSPPGKEHVFCTGMNEKFSPLRVKFKVTEVNPEIALQNLEEVQEFID TNYPGENAKDQCELYKIKAQEAMTKQLEMRLLIEPTHRKESVTPYKEKNTQSFFSKNLDTTSRIDKMISS VITMENLKILAKEADTLSGKDREKLVEYFKTLPSEQLAEIKAESETAQKAWDEQYGLVLRDK |
| - |
| Nucleotide Sequence: 1449 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2394467-2395915 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGACAACTTCCAAGCTTGAAAAAACGGGTTTGCATGTTCATGAAAAAATCAAACATATGGTCAAGAATT ATGGAACGATGATAACCGGTATTCCTGCCGAAATATTAGGGCAAAATGAGGCAGAAATTTCGGTTGGATA TGTAAAAAAAATGGGAAATATGAAAGAAAATATTGCTGAAGTAGTTCGAAAATCTGAAATGACTCAACCC ACAAACAGCTGCGGAAAAGCGAGCAATGAAGTGTGTGATTTACTTTTAGGAACAGAAGGAGCGAGCGAAT TCGAAAAATCAAGCTATCAAGTATTATCTGGGGATGGCAGTAATTTGAAAGGTTCTCTACCCAATAAAAA TTTACTGGTCAGGGTTGAAATGGATCGATTTAATGCTCCTCAAAAATACCAAAAAATAAAAAGAGAGGAG TTTAATCCCGAGACCGCGGAAAAAAATAAAATTTATCTACTGGAAGATCAGCTGGTATATCTCGATATAT TTGGAAAAGTCATCGACCTTGGACAGACATCAGACACATGTCATAGACTATTTAATGCTATTACCACCCC TTTTTATCAAAATTATATTCTTTATGATGAGTATATTGATCCGGAAGAAAGTGCTGAGGAAGCGGCCATG TTTGAAATGGGTGAGATAGTTAAAGCTAAAATGAAAAACATAGATTGTTGGACAGCAACCCATTCTTTTA CTATATTTGTTCCTGAATCGGACAGCGAAGACACACGCACATTATATCCTTACCAGGCATATTGGACCAG CCATACTTTGCAACAATGGTTTTCCGGTGATAAAGATGAAAAATTATCACGCTTGGGTATCGATGGCTAT ATCGAAAAACTGGCTCTATTAGGCACAACAACCGATAGCAAAATACGCTCCAGCATTTATGGAGAACTAT TTTCTCCTCCAGGAAAAGAACATGTTTTTTGTACCGGGATGAACGAAAAATTCTCGCCATTACGAGTCAA ATTTAAAGTCACTGAAGTTAATCCAGAAATAGCATTGCAAAATTTAGAAGAAGTTCAAGAGTTTATTGAT ACGAATTATCCTGGCGAAAACGCGAAAGATCAATGCGAACTTTATAAAATAAAAGCGCAAGAAGCGATGA CTAAACAACTTGAGATGCGACTTCTAATAGAGCCGACTCATCGAAAAGAATCAGTAACCCCCTATAAAGA AAAAAACACACAATCTTTCTTTAGCAAAAACTTAGATACAACCAGTAGAATAGATAAAATGATCTCATCA GTCATTACGATGGAAAACCTCAAGATTCTTGCAAAAGAAGCAGATACCCTCTCTGGAAAGGATCGTGAAA AGTTAGTGGAGTATTTTAAAACATTACCATCAGAGCAGCTGGCAGAAATCAAGGCTGAATCAGAAACAGC TCAAAAAGCCTGGGATGAACAATACGGGTTAGTTCTTCGTGATAAGTGA |
| Reference |
(1) Gan N et al. (2019). Legionella pneumophila inhibits immune signalling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N. Nat Microbiol. 4(1):134-143. [PudMed:30420781] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |