| Effector Protein ID: 52842351 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legK2 |
| Locus tag | lpg2137 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2384233..2385849 [-] |
| Product | calmodulin-dependent protein kinase |
| Effector type | Protein |
| Descripton | LegK2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegK2 is a protein kinase involved in endoplasmic reticulum recruitment and intracellular replication. (Hervet, et al. 2011) |
| UniProt ID | Q5ZTM4 |
| KEGG ID | lpn:lpg2137 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pkinase_Tyr [PF07714], Evalue: 2.6e-05, Aligned region: 79..228 Pkinase [PF00069], Evalue: 0.0001, Aligned region: 78..226 |
| Protein Sequence: 538 a.a. [Download] |
| >gi|52842351|ref|YP_096150.1| calmodulin-dependent protein kinase [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MVYYINLKEQPLHQDKEILTQLIKQYLLSGSSQSALFANHPYTLNDEDGNEIEFLLSHDIYKNQREDGIT EFLILNGSQIGRGTKGVVIQSNHAMYLIDDELVIFPKENVLKVLYQNFINAEELIKQESVNYSILSGNST AELVNLQGGNQGFFMQKEEGYALEELLEDIDSLQKLTFSDKMELAISFLTELENLHNKGYAHGDLTFKNI LYNEKNNQLKIIDAGEMKVADERFWAQDISIAIEMISLLFTTNETNQFKASRYWSDEPTVRRIVNPNPVE AKLNRILNSEYRCVSDLKLAIERNYNEYLNNSNLVLKKNVELESEALGLQAYKNQMSKQQLLGEIQGFKE NYWNMKDLLTLTNRHHLRVFLEYLDNICSAFKDDKTDEKSARAAYDFLNAQINKLFEDNSKNSKPSFESF SEDVQRFLIHIDTYLMKNPSACSNSIASTIQLLKQLDNKKSFNPEQSFKDFCSYKEITIQLLLKPFETPV AEMASAPAIASDLIEKQSDTKRKLQEMKSSANQDKQPIFTPSLMRGPS |
| - |
| Nucleotide Sequence: 1617 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2385849-2384233 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGGTTTATTACATAAATTTGAAGGAACAACCTTTACATCAAGATAAAGAAATTTTAACGCAGTTAATTA AGCAATATTTATTGTCTGGTTCCAGTCAGTCCGCATTATTTGCCAACCATCCTTATACGCTAAACGATGA AGATGGAAATGAAATAGAATTCCTCTTAAGTCATGATATTTACAAAAATCAACGTGAGGATGGTATTACG GAGTTTTTAATTTTAAATGGCTCACAGATAGGGAGAGGAACCAAAGGCGTAGTGATACAGAGTAATCATG CTATGTACTTAATCGATGATGAATTGGTAATTTTTCCTAAAGAGAATGTACTGAAAGTTTTATATCAGAA CTTTATCAATGCCGAGGAGCTAATAAAACAGGAATCTGTCAATTATTCGATTTTATCAGGAAATTCAACT GCAGAATTAGTCAATTTGCAAGGAGGAAACCAAGGATTTTTTATGCAAAAAGAAGAAGGATATGCCTTGG AAGAACTTCTTGAGGATATAGACTCGCTTCAAAAATTGACATTTTCAGACAAAATGGAGTTAGCCATTTC ATTTTTAACTGAGTTGGAAAATCTGCATAACAAAGGCTACGCCCATGGCGATTTAACTTTCAAAAATATT TTATATAACGAAAAAAATAATCAATTAAAAATTATTGATGCAGGAGAAATGAAAGTAGCAGATGAACGCT TTTGGGCACAGGATATTTCAATTGCCATAGAAATGATATCACTCTTGTTTACAACTAATGAAACAAATCA ATTTAAGGCATCACGCTATTGGTCTGATGAACCTACAGTCAGGCGAATAGTTAACCCCAACCCAGTAGAA GCAAAGTTAAATAGAATTTTGAACAGTGAATATCGTTGTGTTTCAGATTTAAAGTTAGCTATTGAAAGGA ATTACAATGAATATCTAAATAATTCGAATCTGGTTTTGAAAAAAAACGTTGAACTAGAAAGTGAAGCTTT GGGTTTACAAGCATACAAAAATCAAATGAGCAAACAACAGTTGTTGGGAGAAATTCAAGGATTTAAAGAA AATTATTGGAATATGAAAGATTTGTTGACCTTGACAAATCGACATCATCTTAGGGTATTTTTGGAGTATT TAGATAATATCTGTTCCGCATTTAAAGATGATAAAACTGATGAAAAGTCGGCCAGAGCGGCCTATGATTT TCTAAACGCACAAATCAATAAATTATTCGAAGATAATTCAAAAAACTCAAAACCAAGTTTTGAAAGTTTC TCAGAAGATGTTCAGCGATTTTTAATTCATATTGATACCTATTTAATGAAAAATCCCTCTGCTTGCTCTA ATTCCATAGCTTCCACCATTCAGTTATTGAAACAGTTGGATAATAAAAAGAGTTTTAATCCTGAGCAATC TTTTAAGGATTTCTGTTCATATAAAGAAATTACGATTCAACTGTTATTAAAGCCATTTGAAACACCAGTG GCTGAAATGGCTAGTGCGCCAGCTATAGCATCAGATTTAATTGAAAAGCAATCTGACACCAAAAGAAAAC TTCAAGAAATGAAATCTTCTGCAAATCAAGATAAGCAACCTATATTTACCCCTTCATTGATGCGAGGCCC AAGCTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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| experimental literature |
| in silico analysis literature |