SecReT4
Effector Protein ID: 52842193
T4SS name [ID]Dot/Icm [5]
Gene symbollegG1
Locus taglpg1976
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]2215443..2216303 [+]
ProductUVB-resistance protein UVR8
Effector typeProtein
DescriptonPieG/legG1
T4CP requirementT4CP Depedent
Target/EffectionLegG1 has an RCC1 domain which can act as a guanine-nucleotide dissociation stimulator for the Ran GTP-binding protein (de Felipe, et al. 2005)
UniProt IDQ5ZU32
KEGG IDlpn:lpg1976
PDB IDNA
Domain hit(s) vs Pfam RCC1 [PF00415], Evalue: 3.3e-29, Aligned region: 61..105
RCC1 [PF00415], Evalue: 3.3e-29, Aligned region: 118..163
RCC1 [PF00415], Evalue: 3.3e-29, Aligned region: 175..219
Protein Sequence: 286 a.a.     [Download]
>gi|52842193|ref|YP_095992.1| UVB-resistance protein UVR8 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MHLELHQINGNDPLGTIIGERNYQLPIPLPYTMKTVKQIHSGIWHTVIRGYDQYNRPQIATFGKNYDGQL
GTGDCENRDTPTPIKLPPEMLTFHAIQTGFFHTIATGLDKNGFPIVASCGYNSDGQLGCGDKDNKNTLIP
IKLPENMKSVEMVATGVKHTVIVGKDINNKPVVATCGHNGYGQLGTGDEENRLCLTPIGIPEDITSVDYV
GAGAYHTVICGRNIKNQPIITLCGCNSDGELGFAPQKIAKKSSLMTNPAMFFPPRQDKSAINNLMKISKF
SPCNLL
-
Nucleotide Sequence: 861 bp     [Download]
>gi|52840256|ref|NC_002942.5|:2215443-2216303 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
TTGCATCTTGAATTGCATCAAATAAATGGCAATGACCCATTGGGAACCATAATTGGGGAAAGGAACTACC
AGTTACCGATTCCATTGCCTTACACTATGAAAACAGTAAAACAAATACATTCAGGAATATGGCATACTGT
GATTAGAGGCTATGATCAATATAATCGGCCGCAAATCGCTACTTTTGGAAAAAATTATGATGGTCAATTA
GGCACAGGCGATTGTGAAAACCGGGATACACCTACCCCGATAAAGCTTCCTCCTGAAATGCTGACGTTCC
ATGCCATCCAAACCGGTTTTTTTCACACCATTGCCACTGGACTTGATAAAAATGGATTCCCTATCGTTGC
AAGCTGCGGTTATAACTCTGATGGCCAATTGGGATGCGGGGATAAAGATAATAAAAACACATTGATTCCC
ATCAAACTTCCAGAAAATATGAAATCAGTAGAAATGGTCGCCACTGGAGTAAAACACACCGTTATTGTGG
GAAAGGACATAAATAACAAGCCTGTGGTTGCAACCTGTGGGCATAACGGCTATGGGCAGCTGGGTACAGG
CGATGAAGAGAACCGGCTCTGCTTAACTCCCATCGGGATTCCCGAGGATATTACAAGTGTCGATTATGTT
GGAGCAGGCGCCTATCATACAGTCATTTGTGGGCGGAATATAAAAAATCAGCCAATTATAACCTTATGTG
GGTGTAATTCAGACGGTGAATTGGGGTTTGCACCACAAAAAATCGCCAAAAAATCATCCCTGATGACCAA
CCCAGCCATGTTCTTCCCACCGCGGCAAGACAAGAGCGCAATCAACAATTTGATGAAAATTAGTAAATTC
TCGCCATGCAATTTGTTATGA

Reference
(1) Escoll P et al. (2017). Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages. Cell Host Microbe. 22(3):302-316.e7. [PudMed:28867389] experimental
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature