| Effector Protein ID: 52842193 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legG1 |
| Locus tag | lpg1976 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2215443..2216303 [+] |
| Product | UVB-resistance protein UVR8 |
| Effector type | Protein |
| Descripton | PieG/legG1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegG1 has an RCC1 domain which can act as a guanine-nucleotide dissociation stimulator for the Ran GTP-binding protein (de Felipe, et al. 2005) |
| UniProt ID | Q5ZU32 |
| KEGG ID | lpn:lpg1976 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | RCC1 [PF00415], Evalue: 3.3e-29, Aligned region: 61..105 RCC1 [PF00415], Evalue: 3.3e-29, Aligned region: 118..163 RCC1 [PF00415], Evalue: 3.3e-29, Aligned region: 175..219 |
| Protein Sequence: 286 a.a. [Download] |
| >gi|52842193|ref|YP_095992.1| UVB-resistance protein UVR8 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MHLELHQINGNDPLGTIIGERNYQLPIPLPYTMKTVKQIHSGIWHTVIRGYDQYNRPQIATFGKNYDGQL GTGDCENRDTPTPIKLPPEMLTFHAIQTGFFHTIATGLDKNGFPIVASCGYNSDGQLGCGDKDNKNTLIP IKLPENMKSVEMVATGVKHTVIVGKDINNKPVVATCGHNGYGQLGTGDEENRLCLTPIGIPEDITSVDYV GAGAYHTVICGRNIKNQPIITLCGCNSDGELGFAPQKIAKKSSLMTNPAMFFPPRQDKSAINNLMKISKF SPCNLL |
| - |
| Nucleotide Sequence: 861 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2215443-2216303 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGCATCTTGAATTGCATCAAATAAATGGCAATGACCCATTGGGAACCATAATTGGGGAAAGGAACTACC AGTTACCGATTCCATTGCCTTACACTATGAAAACAGTAAAACAAATACATTCAGGAATATGGCATACTGT GATTAGAGGCTATGATCAATATAATCGGCCGCAAATCGCTACTTTTGGAAAAAATTATGATGGTCAATTA GGCACAGGCGATTGTGAAAACCGGGATACACCTACCCCGATAAAGCTTCCTCCTGAAATGCTGACGTTCC ATGCCATCCAAACCGGTTTTTTTCACACCATTGCCACTGGACTTGATAAAAATGGATTCCCTATCGTTGC AAGCTGCGGTTATAACTCTGATGGCCAATTGGGATGCGGGGATAAAGATAATAAAAACACATTGATTCCC ATCAAACTTCCAGAAAATATGAAATCAGTAGAAATGGTCGCCACTGGAGTAAAACACACCGTTATTGTGG GAAAGGACATAAATAACAAGCCTGTGGTTGCAACCTGTGGGCATAACGGCTATGGGCAGCTGGGTACAGG CGATGAAGAGAACCGGCTCTGCTTAACTCCCATCGGGATTCCCGAGGATATTACAAGTGTCGATTATGTT GGAGCAGGCGCCTATCATACAGTCATTTGTGGGCGGAATATAAAAAATCAGCCAATTATAACCTTATGTG GGTGTAATTCAGACGGTGAATTGGGGTTTGCACCACAAAAAATCGCCAAAAAATCATCCCTGATGACCAA CCCAGCCATGTTCTTCCCACCGCGGCAAGACAAGAGCGCAATCAACAATTTGATGAAAATTAGTAAATTC TCGCCATGCAATTTGTTATGA |
| Reference |
(1) Escoll P et al. (2017). Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages. Cell Host Microbe. 22(3):302-316.e7. [PudMed:28867389] 
|
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
|
|
(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
|
| experimental literature |
| in silico analysis literature |