| Effector Protein ID: 52842180 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg1963 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2196799..2198898 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | PieA/lirC |
| T4CP requirement | T4CP Depedent |
| Target/Effection | PieA is recruited to the cytoplasmic face of the LCV and overexpression alters lysosome morphology through an unknown mechanism. (Ge and Shao, 2011) |
| UniProt ID | Q5ZU45 |
| KEGG ID | lpn:lpg1963 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 699 a.a. [Download] |
| >gi|52842180|ref|YP_095979.1| hypothetical protein lpg1963 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MQEKIINLGKGLKKVNEGIKKHISRAEEFLYLANQWEKENIKINDLLNGVQFTVNDKKMSGQEIKEELSN LIERYNNFLKKNLKGERSETLELKEIQQQLTNLYNAVNDIYTYLSINKTEFFLEAIKSCYKKDQRMGSTI QFVLKIADHLSKERLQFNLNLNSQFAEASESFQEVTTKFYREVATPRIESAQKLLELMNNFVDQYISQGA SPEDAIKKLKPFEKYFTIEISHYEEFGHLVYKTNFNCNPALFDVNPIEFLNELFVQFYKDTTLSSRSKTA LKQVLDKFEITYEVPKTWYGYIGWDIPIVTDKNSVLVTYDKQAYYRYHQESGQREMEFFETIERCLDKSK DIIIATKKENLKDQKEFSKLIDKAIKELEETKKKRIFQKEPHELVTSIINKSIKLLQDLKNNMPLRREDL VMVILSTENALNAAKSKLKPQEINLSEPEKCIKNFKKILAIKQKEELCFYKSDEEQSIFSKHINSELREL VESYQVQKRSEKELVIEPEKMNSPQRIEPKEEDKKIDLNKKMNLYRVQKIMKNFVFEYCGYKGGKKVKEG GATIEELKNKLKDFRDYFQIEIVMNDKSGSEELNIIFNYQNIKNKNPHDLFNELFKKFTEDIGYSGMGSR SIEALKRALAKNNITYTNGYYGKTATLTSLLWSKEPPVITDEKNIFKLSDEKHLSENKEDIRGKGITNI |
| - |
| Nucleotide Sequence: 2100 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2198898-2196799 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGCAAGAAAAAATTATCAACTTAGGGAAAGGGCTTAAAAAGGTTAATGAAGGCATTAAAAAACATATTT CCCGAGCAGAAGAGTTCCTCTACTTGGCGAACCAATGGGAAAAAGAGAATATTAAGATTAATGATTTATT GAATGGAGTGCAGTTTACAGTTAATGATAAAAAAATGTCGGGTCAAGAAATTAAAGAAGAACTATCTAAT CTAATAGAAAGATATAATAATTTTCTAAAAAAAAACTTAAAAGGGGAAAGAAGCGAAACATTAGAACTAA AGGAGATTCAGCAACAACTTACTAATTTATACAATGCTGTTAATGATATTTATACTTATTTATCCATAAA TAAAACAGAGTTTTTTCTCGAAGCAATCAAGTCTTGCTATAAAAAAGATCAGAGGATGGGTAGTACAATC CAGTTTGTGCTGAAGATCGCGGATCATCTTTCTAAGGAGAGACTGCAATTTAATTTGAATTTAAATTCGC AATTTGCAGAAGCCTCCGAGAGTTTTCAGGAGGTAACTACCAAATTTTACAGAGAGGTTGCTACTCCTAG AATAGAATCTGCACAAAAATTGTTGGAATTGATGAATAATTTCGTAGACCAATATATATCACAAGGAGCA AGTCCAGAAGATGCAATAAAAAAACTTAAGCCATTTGAGAAATATTTTACTATTGAAATCTCGCATTATG AAGAGTTTGGGCATTTAGTATATAAAACAAACTTTAATTGTAATCCAGCGCTATTTGATGTTAACCCCAT TGAATTTTTAAATGAATTATTTGTGCAATTTTATAAAGACACCACTTTATCATCTCGCTCTAAAACAGCT TTAAAACAAGTGCTTGATAAATTTGAGATTACTTATGAGGTGCCAAAGACATGGTATGGTTATATTGGCT GGGATATCCCTATAGTAACTGATAAAAATTCAGTATTAGTTACTTATGACAAACAAGCTTATTACAGATA TCATCAAGAAAGCGGCCAGAGAGAAATGGAGTTTTTTGAGACAATTGAGCGCTGTTTGGATAAGTCGAAA GACATTATTATTGCGACTAAAAAGGAAAATTTAAAAGACCAAAAAGAGTTTTCTAAATTGATAGATAAGG CTATTAAGGAGTTAGAAGAAACAAAAAAGAAAAGAATTTTTCAAAAGGAGCCGCATGAATTGGTAACAAG TATTATCAATAAATCAATAAAGTTGCTGCAAGACTTGAAAAATAATATGCCATTAAGACGAGAAGATTTG GTCATGGTAATCTTAAGTACTGAAAATGCTTTAAATGCAGCAAAATCAAAATTAAAGCCACAAGAAATCA ATTTATCCGAACCGGAAAAATGCATTAAAAATTTTAAAAAGATATTAGCAATAAAACAGAAAGAAGAGCT TTGTTTTTATAAATCAGATGAAGAACAATCTATTTTCTCCAAACACATAAATTCTGAGCTTAGAGAACTT GTCGAATCTTACCAGGTTCAAAAGAGAAGTGAAAAAGAGTTGGTTATTGAGCCAGAAAAAATGAATTCAC CACAGAGAATAGAACCAAAAGAAGAAGATAAAAAGATTGATTTAAATAAGAAAATGAATTTATACCGTGT TCAAAAAATTATGAAAAATTTTGTATTTGAGTATTGCGGGTATAAGGGAGGGAAAAAAGTAAAAGAGGGA GGAGCAACAATAGAAGAACTTAAAAATAAACTCAAAGATTTTAGAGATTATTTTCAAATAGAGATAGTGA TGAATGATAAAAGTGGTTCAGAAGAACTCAATATCATATTCAACTATCAAAACATCAAGAATAAAAATCC ACATGATTTATTTAATGAGCTCTTTAAAAAATTTACCGAAGACATAGGATATTCTGGTATGGGTTCACGA TCAATCGAGGCTCTTAAAAGAGCATTAGCTAAAAATAATATCACTTATACCAATGGATATTATGGAAAAA CAGCGACTTTAACAAGCCTATTATGGAGTAAAGAGCCACCTGTTATTACTGATGAAAAAAATATATTTAA ATTATCCGATGAAAAGCATTTAAGTGAGAATAAGGAAGATATTCGCGGAAAAGGAATTACGAATATCTAG |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Zusman T; Degtyar E; Segal G (2008). Identification of a hypervariable region containing new Legionella pneumophila Icm/Dot translocated substrates by using the conserved icmQ regulatory signature. Infect Immun. 76(10):4581-91. [PudMed:18694969]
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| experimental literature |
| in silico analysis literature |