| Effector Protein ID: 52842179 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg1962 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2196167..2196733 [+] |
| Product | peptidyl-prolyl cis-trans isomerase |
| Effector type | Protein |
| Descripton | LirB |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZU46 |
| KEGG ID | lpn:lpg1962 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pro_isomerase [PF00160], Evalue: 3.8e-48, Aligned region: 26..185 |
| Protein Sequence: 188 a.a. [Download] |
| >gi|52842179|ref|YP_095978.1| peptidyl-prolyl cis-trans isomerase [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKKIICLLSNLVLTVGIMSAHAETAIIKTSEGNITCELFTKEAPNTVANFVGLATGTKEFKDIKTGKMVK RPFYNGLTFHRVIAGFMIQGGDPLGNGTGGPGYTFDNENTNASFNKPGVLAMANAGPNTNGSQFFITVAP TPELQGGYNVFGQVISGQEVVDKISKMPTDPQDKPITPVVIENITIQK |
| - |
| Nucleotide Sequence: 567 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2196167-2196733 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAAAAAAATTATTTGTTTACTCAGTAACTTAGTGTTAACAGTAGGTATCATGTCAGCACATGCAGAAA CTGCAATTATTAAAACTTCAGAGGGCAACATAACGTGTGAATTATTTACAAAAGAAGCTCCCAATACCGT TGCAAATTTTGTAGGGCTGGCAACTGGAACAAAAGAATTTAAAGACATAAAAACTGGCAAAATGGTTAAA CGCCCTTTTTACAATGGCTTAACCTTTCATCGTGTGATTGCCGGCTTTATGATTCAGGGCGGCGACCCCC TCGGAAATGGGACCGGTGGCCCAGGTTACACATTTGATAATGAAAATACTAATGCCAGTTTTAACAAACC TGGCGTACTTGCCATGGCCAATGCTGGACCAAACACGAATGGCAGTCAATTTTTTATTACCGTTGCACCA ACACCTGAATTACAAGGTGGCTACAATGTTTTTGGTCAAGTCATTTCTGGACAAGAAGTTGTTGATAAGA TTAGCAAGATGCCCACTGATCCACAAGATAAACCCATTACACCTGTAGTCATTGAAAATATTACCATTCA AAAGTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Zusman T; Degtyar E; Segal G (2008). Identification of a hypervariable region containing new Legionella pneumophila Icm/Dot translocated substrates by using the conserved icmQ regulatory signature. Infect Immun. 76(10):4581-91. [PudMed:18694969]
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| experimental literature |
| in silico analysis literature |