| Effector Protein ID: 52842108 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legLC8 |
| Locus tag | lpg1890 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2108003..2109724 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LegLC8 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZUB7 |
| KEGG ID | lpn:lpg1890 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | LRR_6 [PF13516], Evalue: 1.8e-19, Aligned region: 219..242 LRR_6 [PF13516], Evalue: 1.8e-19, Aligned region: 244..267 LRR_4 [PF12799], Evalue: 4e-14, Aligned region: 196..235 LRR_4 [PF12799], Evalue: 4e-14, Aligned region: 221..258 LRR_8 [PF13855], Evalue: 7.5e-11, Aligned region: 170..230 |
| Protein Sequence: 573 a.a. [Download] |
| >gi|52842108|ref|YP_095907.1| hypothetical protein lpg1890 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MIFELNILPNRNFLFIFGDNMPLTSLKKFLKDIGKENIKQHQVKLVLKTSQDIQLFLNALRDSRNHGISS LSELDLSDTRFTNQELSDLVTALNNIPGIKSLRLDSCGLKDSDTVELSKLTHIKKLSLKSNYLKNRPMFN SMLEALYLDYNTELSASYVLFSLSRNAAALKKLSLRNCGVTDANLEYLTRPESRLKSLTHFNLRRNNITH QGVDSFAHLQSLTTIDLSQNTGIGDEGVSRLAPLKQLRTLYLDNCGIGGEGIKAIAKMNLQTVDLSFNPG LKKEWGLDDIRPNHTIRTLLLTFCSLNDNHAKLIVSKFPAATDLNVANNNMTRAGVKTLLSNPIIENLDV STQSLYAKSTGASGTGMISPRIMMKKKEIKQQEKEKAQDLLDTICNTITLKSINLEHTGITSRMLLSLIP DETDHKRYLKKINGVSCKELKPKLEQQIALRKAEKQSSPPVINAVEDSKTSDLMVKSGSSSKTEMQTRED DLIASPDEKIKALELENQKLKDELATARKRIFELENQSLSGSKTRKKTSIPPLAIPVMFQDFAKPGKNET DDNTINSITAIPK |
| - |
| Nucleotide Sequence: 1722 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2109724-2108003 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGATCTTTGAGTTAAATATATTACCAAACAGGAATTTTTTGTTTATATTTGGAGACAATATGCCCCTTA CTTCGTTAAAAAAATTTTTAAAAGATATTGGAAAGGAAAATATAAAACAGCATCAGGTAAAACTTGTCTT AAAAACATCTCAGGATATTCAATTATTTTTAAATGCTTTGCGAGATTCGAGAAATCACGGAATCTCGTCC TTATCTGAACTTGATCTAAGTGATACTCGCTTTACTAATCAAGAGTTGAGTGATTTAGTCACTGCTCTTA ATAATATACCTGGAATTAAATCTTTACGCTTGGATTCTTGTGGTCTTAAGGATAGTGACACAGTGGAGCT TTCCAAATTAACTCACATCAAAAAATTATCATTGAAAAGTAATTACTTAAAGAACCGCCCTATGTTTAAT TCTATGCTTGAAGCATTGTATTTGGATTATAATACAGAACTTAGCGCAAGTTATGTGTTATTTAGTTTAA GTCGCAATGCTGCCGCTTTAAAAAAATTATCCTTGCGTAACTGTGGCGTTACTGATGCCAATTTAGAGTA TTTGACTCGGCCTGAGTCCAGGTTAAAAAGTCTGACACACTTTAATTTGCGAAGAAATAATATCACTCAC CAAGGAGTGGATAGCTTTGCTCATCTTCAATCGTTGACTACTATTGATTTAAGTCAAAATACTGGGATTG GTGATGAGGGTGTATCCAGGCTTGCGCCTTTAAAGCAGTTAAGAACCCTGTATTTGGATAATTGTGGAAT AGGGGGAGAGGGAATTAAGGCAATTGCCAAAATGAATTTGCAGACTGTTGATTTGAGTTTCAATCCCGGG TTAAAAAAAGAATGGGGATTGGATGACATTCGACCTAATCATACCATTCGAACATTATTGCTAACATTTT GCAGCTTAAATGATAATCATGCCAAGCTTATTGTTTCGAAGTTTCCAGCGGCTACCGATTTAAATGTTGC GAATAATAATATGACCAGGGCAGGGGTAAAGACTTTATTAAGTAACCCGATTATAGAAAACTTGGATGTC AGTACCCAATCGCTTTATGCAAAATCAACAGGAGCTTCTGGCACTGGCATGATCTCTCCCCGAATAATGA TGAAGAAAAAGGAAATAAAACAACAGGAAAAAGAAAAAGCGCAGGATTTGCTAGATACTATCTGTAATAC AATCACATTAAAGAGTATTAATCTGGAACATACAGGCATAACCTCCAGGATGTTATTAAGTTTAATTCCA GATGAAACAGATCACAAACGGTATCTTAAGAAAATTAATGGTGTTTCCTGTAAAGAGCTTAAGCCAAAAT TAGAACAACAAATTGCCTTGAGAAAAGCTGAAAAACAAAGTTCTCCTCCTGTAATCAATGCAGTGGAAGA TTCCAAAACAAGTGATTTAATGGTTAAATCTGGCAGTAGTTCCAAGACTGAGATGCAAACCAGGGAAGAT GACTTGATAGCCAGTCCTGATGAAAAAATAAAAGCTCTGGAACTAGAGAATCAAAAATTAAAGGATGAAT TGGCAACAGCTCGTAAAAGAATTTTTGAATTGGAAAATCAGTCTTTATCTGGATCTAAAACAAGAAAAAA AACCTCAATACCACCATTGGCAATCCCGGTGATGTTTCAGGATTTTGCAAAACCAGGAAAAAATGAAACA GATGACAACACCATCAACTCAATAACGGCAATCCCCAAATAG |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Kubori T; Hyakutake A; Nagai H (2008). Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions. Mol Microbiol. 67(6):1307-19. [PudMed:18284575]
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| experimental literature |
| in silico analysis literature |