| Effector Protein ID: 52842106 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg1888 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2105414..2106745 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | lpdA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | The effector protein LpdA was found to contain a functional PLD domain and these enzymes were shown before to convert PC to PA and free choline . it is found to be localized to the LCV during infection thus the combined lipid biosynthetic reactions that might occur on the LCV will include conversion of PC into PA (by LpdA) and then conversion of PA to DAG (by LecE activated PA phosphatase) a process which is expected to result in changes of the lipid composition of the LCV that can affect its fate in the host cell as well as the host proteins and bacterial effectors that will be recruited to the LCV. |
| UniProt ID | Q5ZUB9 |
| KEGG ID | lpn:lpg1888 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | PLDc_2 [PF13091], Evalue: 2.1e-25, Aligned region: 66..213 PLDc_2 [PF13091], Evalue: 2.1e-25, Aligned region: 278..419 |
| Protein Sequence: 443 a.a. [Download] |
| >gi|52842106|ref|YP_095905.1| hypothetical protein lpg1888 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MLQFFEKGLQYSGEKISTDSYLMRKIVEAAIPSADKGTVSAEKMLGLMNPNQIEIVSGSESAYRLIVHKI KEAKKQILIQAFVWEPGTQVVKDIRNALCDIKHEVEVFLLVDQLDRLAQVFYHGEILPKKPKHDPACLGL DNLPQNIKLHIGTHVHNSIASNHNKAIWIDGDVILTGANFQQENYGPNGFHDAAMFIPGGAAEAVFYDFK AMWDKRTNKSDEPEISPIYTGQESTESYRNTNSCSVLYVTNTIRQKWALLPFYRAPLPEDPLNNAYMAAI KYAKHTIRIAVPNLNSPEIIHALADFINNRNGHVYLLMGKGFNDFRERFYGGTNQSAIDYFSSLLDEDRQ NNLQVRWFHRVNNNENSMKKEVIHMKFMSIDGQVVIYGSSNLDLLSLHNSHETNIVIDNADFAQRAIEQL YLPIFETSIPVLISPKRTCFVCS |
| - |
| Nucleotide Sequence: 1332 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c2106745-2105414 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGCTCCAATTTTTTGAGAAAGGTTTGCAATATTCAGGAGAAAAAATTTCCACCGATTCTTATTTAATGA GAAAAATAGTTGAAGCAGCAATTCCCTCTGCTGATAAGGGAACTGTTTCTGCAGAAAAAATGCTGGGCCT GATGAATCCAAATCAGATAGAAATAGTATCGGGTAGTGAGAGCGCATATCGTTTAATAGTTCATAAAATC AAAGAGGCTAAAAAGCAAATACTTATTCAGGCTTTTGTATGGGAGCCAGGAACTCAGGTTGTCAAAGATA TCCGAAATGCGCTTTGTGACATCAAACATGAAGTCGAAGTATTTCTTCTGGTCGATCAGTTGGATCGTTT GGCACAAGTTTTTTATCATGGCGAAATACTTCCTAAAAAACCAAAACATGATCCAGCCTGTTTAGGTTTA GATAATTTACCTCAGAATATTAAATTGCATATAGGTACTCATGTTCATAATTCCATTGCGTCCAACCATA ATAAAGCCATCTGGATTGATGGGGATGTCATTTTGACAGGGGCTAATTTTCAGCAGGAAAATTATGGTCC TAATGGGTTTCATGATGCCGCCATGTTTATTCCTGGCGGCGCAGCGGAAGCGGTTTTTTACGATTTTAAA GCAATGTGGGATAAGCGCACCAATAAATCTGATGAACCAGAAATTTCTCCCATATATACAGGCCAGGAGT CAACAGAATCTTATAGAAATACAAACTCTTGTTCTGTGCTCTATGTGACAAATACTATCAGGCAGAAATG GGCGCTTCTCCCTTTTTATAGGGCGCCTTTACCTGAAGATCCATTGAATAACGCCTACATGGCTGCTATT AAATATGCCAAACATACTATTCGAATCGCTGTTCCCAATTTAAACTCGCCGGAAATCATCCATGCCCTGG CGGATTTTATTAATAATAGAAATGGCCATGTCTATCTATTGATGGGAAAGGGATTCAATGATTTTCGCGA GAGATTCTATGGCGGTACAAATCAGAGTGCGATAGATTATTTTAGTTCACTACTTGATGAGGACAGGCAA AATAACTTGCAAGTTCGTTGGTTTCATCGTGTGAATAACAATGAAAATTCTATGAAAAAAGAGGTTATTC ATATGAAATTTATGTCAATTGATGGGCAGGTGGTTATTTACGGTTCATCGAATCTTGATTTGTTAAGCTT ACATAACAGCCATGAAACAAATATTGTAATTGATAATGCTGATTTTGCACAAAGAGCAATAGAACAATTA TATCTACCCATTTTTGAAACGAGTATACCTGTATTGATATCGCCTAAAAGAACCTGTTTTGTTTGTTCTT GA |
| Reference |
(1) Viner R et al. (2012). Identification of two Legionella pneumophila effectors that manipulate host phospholipids biosynthesis. PLoS Pathog. 8(11):e1002988. [PudMed:23133385] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |