| Effector Protein ID: 52842102 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legC2 |
| Locus tag | lpg1884 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2102459..2103676 [+] |
| Product | microtubule binding protein |
| Effector type | Protein |
| Descripton | YlfB/legC2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Vesicle trafficking |
| UniProt ID | Q5ZUC3 |
| KEGG ID | lpn:lpg1884 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | IncA [PF04156], Evalue: 5.2e-05, Aligned region: 83..244 |
| Protein Sequence: 405 a.a. [Download] |
| >gi|52842102|ref|YP_095901.1| microtubule binding protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MTDTPKANLAVDEIKEDTPKDQPLPEENTEILVKKLKVLETTQENFDQIKKHIAAVIDSLAKNRSFFGRV AAYWGEMQLWLKITLGIVLVVPTLTLGIAIQVASLIVVSVLTLVTYVGSALLLENHVQKEEHITDRLKEE MIGLADNLGKVIESFEPLRKQIAEQIEYFHKENDRLNLNVTQLSDHIMRLTKQAEQLQKTEQTLRKVREE LEKTSETLDEKVQVQTELLQINQEELNRIREEIAKNEIELSEKISELDQVKKEMSVEIEKAETVTQVLKN TVEKLSQTAIADHNHRESFQNKLNDFLSNKEQSFNDVAQRICEAEHELCFVKEELNFSNKRYQELLERQE EVVKRLEQLQFSRKPTPYSNAKVLGKLGIMATEEKESPTPVSAEENTIPTQTLTG |
| - |
| Nucleotide Sequence: 1218 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2102459-2103676 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGACAGACACTCCAAAAGCTAATCTAGCCGTTGATGAAATTAAAGAGGATACCCCCAAAGACCAGCCCC TCCCTGAAGAAAACACGGAAATATTGGTAAAAAAACTGAAAGTATTGGAAACTACCCAAGAAAATTTTGA TCAAATCAAAAAACATATTGCTGCGGTTATAGATTCCTTGGCAAAAAATCGCAGTTTTTTTGGCCGTGTT GCCGCCTACTGGGGAGAAATGCAGTTATGGTTAAAAATTACTCTTGGAATAGTATTGGTTGTTCCCACCT TGACACTTGGAATTGCAATTCAAGTGGCCTCTCTTATAGTAGTTAGCGTCCTGACTCTGGTGACTTATGT TGGTAGTGCCCTGCTTCTTGAAAATCATGTTCAAAAAGAAGAGCATATTACTGATCGTTTAAAAGAAGAA ATGATAGGTTTGGCAGATAACCTGGGAAAAGTTATCGAGTCTTTTGAGCCTCTCCGCAAACAAATTGCAG AACAAATTGAGTATTTTCATAAAGAAAATGATAGATTAAACCTCAACGTTACTCAACTAAGTGATCATAT TATGCGATTAACAAAACAAGCTGAACAATTACAAAAAACCGAACAAACTTTGCGTAAAGTCAGAGAAGAA TTGGAAAAAACATCTGAAACTCTGGATGAAAAAGTACAAGTTCAAACCGAATTACTACAGATAAATCAGG AAGAATTAAACAGAATCAGGGAAGAAATTGCAAAAAATGAAATTGAATTATCTGAAAAAATTTCTGAGCT GGATCAAGTTAAGAAAGAAATGTCAGTAGAAATTGAAAAAGCCGAAACTGTTACCCAAGTATTAAAAAAT ACTGTAGAAAAACTGTCCCAAACTGCTATTGCAGATCACAATCATAGGGAATCGTTTCAAAATAAATTGA ACGATTTTCTCTCTAATAAAGAACAAAGTTTCAATGATGTTGCTCAACGTATATGTGAAGCCGAGCACGA ACTATGCTTTGTTAAAGAAGAATTAAACTTTAGTAACAAACGTTATCAGGAACTATTGGAACGTCAAGAA GAAGTAGTTAAACGTTTGGAACAACTCCAATTTTCCCGTAAGCCTACGCCATATAGTAATGCAAAAGTAC TTGGTAAATTAGGTATTATGGCTACTGAGGAAAAAGAGTCTCCAACACCTGTTTCAGCAGAAGAAAATAC AATCCCAACTCAAACTCTCACAGGTTAG |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
|
(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
|
|
(3) Rasis M; Segal G (2009). The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors. Mol Microbiol. 72(4):995-1010. [PudMed:19400807]
|
| experimental literature |
| in silico analysis literature |