SecReT4
Effector Protein ID: 52841713
T4SS name [ID]Dot/Icm [5]
Gene symbollegK1
Locus taglpg1483
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]1638274..1639863 [+]
Productserine/threonine-protein kinase
Effector typeProtein
DescriptonLegK1
T4CP requirementT4CP Depedent
Target/EffectionThe canonical serine/threonine kinase activity of LegK1 is essential for potent activation of the NF-kB pathway. LegK1 mimics host IKK and directly phosphorylates the Ser32 and Ser36 residues of the inhibitory IkBa protein, leading to IkBa ubiquitination/degradation and subsequent nuclear translocation of p65. (Ge and Shao, 2011)
UniProt IDQ5ZVF7
KEGG IDlpn:lpg1483
PDB IDNA
Domain hit(s) vs Pfam Pkinase [PF00069], Evalue: 7.3e-27, Aligned region: 86..362
Pkinase_Tyr [PF07714], Evalue: 2.4e-14, Aligned region: 86..290
Protein Sequence: 529 a.a.     [Download]
>gi|52841713|ref|YP_095512.1| serine/threonine-protein kinase [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MPRTMFFSVDAANLQNLQITNQKAFAALESYLNDNDSPGAWNNNQGYKYTHKDVTYCFSFNQSLVRRPRK
SDQKKHTFEIFDPNKNPLGKGAYGIVYPILGTIQFEFGNAIKRPPKNKLVKIQNHSERDQSHSVLREYQG
LLQSGHIAVKPPIFVENKESKFSYLIMEKAEGIVLEKFLNPIKRLDLSEEVPELNLINRIEITFAILKAI
KEQVTDKHLIHRDIKPGNIIIDFSKSPPIAKVIDFGFVLRASEQDYRRCGTRAYRAPESFNTQALYTAKA
DVWSTGRILSYLWGDKYTNYYISRDKGLDYVIEKSRNELLFSDPELELYLTKEDKSKIRSCLSAMLIVDP
EERGSIDKAIKQFSQIDFEKYKRLKRSTNFEIDLTDNDIKLRKQLNSIHLHLITLQSKEKDLRNRACFDA
ANAMSQLVSKLTAYTNYLEKNPDPFLIKRYKECCIAEIDLANLTLQNHRDALWLVAELSTAILLLGIGYL
FAFGINYYNTGRLGLFSQTRSEKLVEEMKSSVLGIAVGN
-
Nucleotide Sequence: 1590 bp     [Download]
>gi|52840256|ref|NC_002942.5|:1638274-1639863 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATGCCTCGTACCATGTTTTTTTCCGTTGATGCAGCTAATCTCCAAAATTTACAAATTACAAATCAAAAAG
CTTTTGCAGCGTTGGAGAGTTATCTGAATGATAATGATTCACCAGGTGCCTGGAATAATAATCAAGGATA
CAAATATACTCATAAGGATGTTACTTATTGCTTCTCATTTAATCAATCCTTAGTGAGACGCCCAAGAAAA
TCGGATCAAAAAAAACACACATTTGAAATTTTTGACCCTAATAAGAACCCTTTAGGCAAGGGAGCGTACG
GTATTGTGTATCCCATTTTAGGTACAATTCAGTTTGAATTTGGAAATGCAATTAAAAGACCACCAAAGAA
TAAATTAGTTAAAATACAAAACCATAGTGAACGCGATCAAAGTCATTCTGTACTACGTGAATATCAAGGA
CTTCTTCAATCAGGGCATATAGCGGTTAAACCGCCAATATTTGTAGAAAACAAAGAGAGTAAATTCAGTT
ACTTGATTATGGAAAAAGCGGAGGGTATCGTTTTAGAGAAGTTTCTAAATCCCATTAAGCGGCTTGATTT
GTCTGAAGAGGTACCTGAGCTTAATCTTATTAATCGGATTGAGATTACTTTTGCCATTTTAAAAGCAATT
AAAGAGCAGGTGACGGATAAGCATTTGATTCATCGAGATATAAAACCAGGAAATATTATAATCGATTTTA
GCAAGTCGCCTCCGATAGCTAAAGTAATCGATTTTGGTTTTGTGCTTAGGGCGTCAGAACAGGATTATCG
TCGTTGTGGAACCCGAGCATACAGAGCGCCCGAATCTTTCAATACCCAGGCATTGTACACAGCAAAAGCT
GATGTTTGGTCAACAGGCAGAATATTAAGTTATTTGTGGGGAGATAAATATACTAATTACTATATCTCTC
GTGATAAGGGTCTGGACTACGTGATTGAGAAGTCAAGAAACGAGCTACTCTTCTCTGACCCGGAATTGGA
ACTCTATTTAACCAAGGAAGATAAAAGTAAAATCAGATCGTGCCTAAGCGCAATGCTTATAGTTGACCCT
GAGGAAAGAGGATCTATAGATAAGGCTATCAAGCAGTTTTCCCAAATTGATTTTGAAAAATATAAAAGAT
TGAAACGCTCTACAAATTTTGAAATTGATTTAACAGATAATGATATTAAATTAAGAAAACAGCTCAATTC
AATTCACCTGCATTTGATTACCCTACAGAGCAAAGAAAAAGATTTGCGTAATAGAGCATGTTTTGATGCA
GCAAATGCAATGAGCCAATTGGTTAGTAAGCTCACCGCCTACACCAATTATCTTGAAAAAAATCCAGATC
CATTTTTAATAAAACGTTATAAAGAGTGCTGCATAGCAGAAATAGATTTAGCCAATTTGACTTTGCAAAA
TCACCGTGATGCCTTATGGTTAGTGGCTGAGTTATCAACTGCTATCCTTTTGCTTGGTATAGGGTATTTA
TTTGCTTTTGGGATAAATTATTACAACACAGGTCGTCTGGGATTATTTTCTCAAACCAGGTCTGAGAAAT
TGGTGGAGGAAATGAAAAGCTCTGTGTTGGGTATTGCGGTTGGAAATTAA

Reference
(1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890]
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(3) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602]
(4) Ge J; Xu H; Li T; Zhou Y; Zhang Z; Li S; Liu L; Shao F (2009). A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors. Proc Natl Acad Sci U S A. 106(33):13725-30. [PudMed:19666608] experimental
 
experimental experimental literature
in_silico in silico analysis literature