| Effector Protein ID: 52841638 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | licA |
| Locus tag | lpg1408 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1553994..1555145 [+] |
| Product | choline kinase |
| Effector type | Protein |
| Descripton | LicA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Polyubiquitinylation of host proteins. |
| UniProt ID | Q5ZVN2 |
| KEGG ID | lpn:lpg1408 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Choline_kinase [PF01633], Evalue: 3.0e-20, Aligned region: 97-304 APH [PF01636], Evalue: 4.4e-11, Aligned region: 77-308 |
| Protein Sequence: 383 a.a. [Download] |
| >gi|52841638|ref|YP_095437.1| choline kinase [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MTFMKLYFFGDDNNKPKLSEHLIIYILSLLDPKSQSVASLVNKDWSRLVQLTRQYLSMLPVIHRIPLFAN LGLDVLKLKLMTGGMTNSTVRLRIKNAPEKWVMRIPGIGSSAFITRRDEAHNAKQAEKLGLNVPIAFFDP EDGLQVTRFIEGVHSLDDKALARKEILHEVASMMRRLHKSPPFDNNTLFFERNEELLDLLKRKPFNFPGE IEFVEQQMKNLKEIFSSYHIQQFPCHNDTTPLNFILSENPEIKGSEKIHQIDWEYSSNNDFIWDLVYFMV EAKLNREQQLILLKAYFNTEELSDSLLAWIEVYKPIIEWWITIWSWTQLANGANAVDLSSYEQLGLERYH NTLSHLKSEDYVKALALIEADSHSLTFTGQRPF |
| - |
| Nucleotide Sequence: 1152 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:1553994-1555145 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGACGTTTATGAAATTATATTTTTTTGGTGATGATAATAATAAACCCAAATTAAGCGAACATTTAATCA TTTACATACTCAGTTTGCTAGATCCCAAGTCTCAGTCTGTTGCTTCTTTAGTGAATAAAGACTGGTCCCG GCTGGTTCAATTGACACGGCAATACCTGTCTATGTTACCGGTGATTCATCGAATACCTTTATTTGCGAAT TTGGGTCTTGACGTTTTGAAATTAAAATTAATGACAGGTGGCATGACGAATTCAACAGTTAGGCTAAGAA TCAAAAATGCGCCTGAGAAATGGGTTATGCGGATTCCTGGAATAGGCTCTTCAGCATTTATAACCAGAAG AGATGAAGCTCACAACGCTAAACAAGCCGAAAAACTTGGACTGAATGTTCCAATAGCTTTCTTTGATCCT GAAGATGGGTTGCAGGTAACGCGCTTTATAGAAGGAGTGCATTCTCTGGATGATAAAGCCTTGGCCCGCA AGGAAATTCTGCATGAGGTAGCATCTATGATGAGAAGACTTCATAAATCTCCTCCCTTTGATAATAACAC GCTTTTTTTTGAGCGAAATGAAGAGTTATTGGATTTATTAAAACGAAAACCCTTTAATTTCCCAGGGGAA ATAGAATTTGTTGAGCAACAAATGAAAAATCTAAAGGAGATTTTTTCTTCTTATCATATTCAGCAATTTC CTTGCCACAATGATACAACGCCACTTAATTTTATCTTGTCCGAAAATCCAGAAATCAAGGGTTCTGAAAA GATTCATCAGATTGATTGGGAATATTCAAGTAATAATGATTTTATTTGGGATTTGGTTTATTTTATGGTT GAGGCCAAGCTAAACCGCGAACAACAGCTTATTCTGTTGAAAGCTTACTTTAATACAGAAGAGCTGAGTG ACTCTCTGTTGGCATGGATAGAGGTTTATAAACCCATCATTGAGTGGTGGATAACCATTTGGTCATGGAC GCAATTGGCAAATGGAGCTAATGCAGTTGATTTGAGTTCTTATGAGCAACTAGGGCTTGAACGGTATCAT AACACCTTAAGTCACTTGAAAAGTGAGGACTATGTCAAAGCCCTGGCACTGATTGAAGCAGATAGTCATA GCCTTACTTTTACGGGGCAGAGGCCTTTTTAG |
| Reference |
(1) Ensminger AW et al. (2010). E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates. Infect Immun. 78(9):3905-19. [PudMed:20547746] 
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| experimental literature |