| Effector Protein ID: 52841598 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg1368 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1513119..1514696 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | Lgt1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Glucosyltransferase; inhibition of host protein synthesis causing activation of NF- B pathway. |
| UniProt ID | Q5ZVS2 |
| KEGG ID | lpn:lpg1368 |
| PDB ID | 2WZF |
| Domain hit(s) vs Pfam | Glyco_transf_88 [PF16849], Evalue: 2.1e-195, Aligned region: 116-523 |
| Protein Sequence: 525 a.a. [Download] |
| >gi|52841598|ref|YP_095397.1| hypothetical protein lpg1368 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKARRDQQLSKLRMRFFSALNHTSEIDLQVLFNDLKSILTLDSIEHLKEGSVAYAIIQELLKQDDAQNKI QSFLHGAIKNVIHPGVIKGLTPDEINWNVAKAYPKYYEHEEFPDVTFGGFKVRDSNEFKFKTNIQTSIWF SIKPDLFMPSKQQEALKRRREQYPGCEIRLIYSSSLLNAEANRQMKAFARKQNISLIDIDSVKTDSPLYP LLKAELAHLGKGGNPAAASDLCRWIPELFNEGFYVDIDLPVDSSKIVEGHQITGGVPIMLNMGSIISEPI APHHRRQEAVCMNTDIIAYSNDKRTQKMMDTVARYLKNIYDDPYTALKDTPLAQTAFFNKCQEERKSIFD LRKGLQDAFRSDSLLQLYDFLGADKFKEVFKLKEAQSKYINEHISEFSEKDLLLNLISDKPSEISQHTLD FVKAKAMYIDIAKEHYSAFYKPLVEEISGPGAIYNALGGAGSFTTTHRRLTGPMLPTTPPRVLQVFCDAH DKGPFVSDNIARWQTNVRDLGVLNREGLSWLPSVG |
| - |
| Nucleotide Sequence: 1578 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:1513119-1514696 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAAAGCAAGAAGGGATCAACAACTCTCTAAATTGCGAATGAGATTTTTTTCAGCGCTCAATCACACAT CTGAAATTGACTTACAAGTGCTTTTTAATGATTTGAAATCAATTCTCACACTGGATAGTATTGAGCATCT CAAAGAAGGCTCTGTAGCGTATGCAATCATTCAAGAACTCTTGAAACAGGATGATGCTCAAAATAAGATT CAATCTTTTTTACATGGAGCGATCAAGAATGTTATTCATCCGGGTGTCATCAAAGGGCTGACCCCTGATG AAATTAACTGGAATGTTGCCAAAGCATACCCGAAATATTATGAGCATGAGGAATTTCCTGATGTGACTTT TGGCGGCTTTAAAGTACGTGATAGTAATGAATTTAAATTTAAGACGAATATACAAACTTCGATATGGTTT AGTATCAAGCCCGATCTTTTCATGCCTTCTAAACAACAGGAGGCTTTAAAAAGAAGAAGGGAACAATACC CTGGTTGCGAAATTAGATTAATTTATTCCAGTTCATTGCTAAATGCAGAAGCAAACCGCCAGATGAAGGC ATTTGCCAGGAAACAAAATATTTCATTAATTGATATCGATAGTGTTAAAACCGATTCACCATTATATCCA TTACTAAAAGCTGAACTTGCACATCTTGGAAAAGGAGGAAATCCTGCTGCTGCCTCCGATCTGTGTCGCT GGATCCCTGAGTTATTCAATGAAGGGTTTTATGTGGATATTGATCTCCCTGTTGATAGTTCAAAAATAGT AGAAGGACATCAAATTACAGGAGGAGTTCCAATCATGCTCAATATGGGCTCCATTATCAGTGAACCCATA GCTCCACATCATAGAAGGCAAGAAGCTGTTTGTATGAATACGGACATTATTGCTTATTCCAATGATAAAA GAACTCAAAAAATGATGGATACGGTCGCCCGATATTTGAAAAATATATACGATGATCCATATACAGCATT AAAAGACACACCTCTTGCGCAAACGGCTTTTTTTAATAAGTGCCAAGAGGAAAGGAAAAGTATATTTGAT TTAAGAAAAGGATTACAAGATGCATTTCGCTCCGATTCATTATTGCAATTATACGACTTTTTAGGGGCAG ACAAATTTAAGGAAGTATTTAAATTAAAGGAAGCTCAAAGCAAATACATTAATGAGCATATAAGTGAATT TAGCGAGAAGGATCTGTTGTTAAATTTGATTTCTGATAAACCTTCCGAGATTAGTCAGCATACACTTGAT TTTGTCAAGGCTAAAGCAATGTACATAGATATTGCCAAAGAGCACTATTCTGCATTCTACAAACCATTAG TCGAGGAGATTTCAGGGCCAGGTGCCATTTATAATGCTTTAGGAGGAGCGGGCAGCTTCACTACCACTCA TAGGCGGTTAACAGGACCTATGTTGCCAACAACCCCACCACGTGTTTTACAGGTATTTTGTGATGCACAT GACAAGGGTCCTTTTGTTTCAGATAATATTGCGCGTTGGCAAACCAATGTTCGAGATCTGGGCGTGTTGA ATCGAGAGGGTTTGAGTTGGTTGCCTTCAGTAGGGTAG |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Tzivelekidis T; Jank T; Pohl C; Schlosser A; Rospert S; Knudsen CR; Rodnina MV; Belyi Y; Aktories K (2011). Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases. PLoS One. 6(12):e29525. [PudMed:22216304] 
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| (3) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
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(4) Fontana MF; Banga S; Barry KC; Shen X; Tan Y; Luo ZQ; Vance RE (2011). Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 7(2):e1001289. [PudMed:21390206]
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(5) Hurtado-Guerrero R et al. (2010). Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase. Biochem J. 426(3):281-92. [PudMed:20030628]
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(6) Belyi Y et al. (2008). Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila. J Bacteriol. 190(8):3026-35. [PudMed:18281405]
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| experimental literature |