SecReT4
Effector Protein ID: 52841598
T4SS name [ID]Dot/Icm [5]
Gene symbol-
Locus taglpg1368
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]1513119..1514696 [+]
Producthypothetical protein
Effector typeProtein
DescriptonLgt1
T4CP requirementT4CP Depedent
Target/EffectionGlucosyltransferase; inhibition of host protein synthesis causing activation of NF- B pathway.
UniProt IDQ5ZVS2
KEGG IDlpn:lpg1368
PDB ID2WZF
Domain hit(s) vs Pfam Glyco_transf_88 [PF16849], Evalue: 2.1e-195, Aligned region: 116-523
Protein Sequence: 525 a.a.     [Download]
>gi|52841598|ref|YP_095397.1| hypothetical protein lpg1368 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MKARRDQQLSKLRMRFFSALNHTSEIDLQVLFNDLKSILTLDSIEHLKEGSVAYAIIQELLKQDDAQNKI
QSFLHGAIKNVIHPGVIKGLTPDEINWNVAKAYPKYYEHEEFPDVTFGGFKVRDSNEFKFKTNIQTSIWF
SIKPDLFMPSKQQEALKRRREQYPGCEIRLIYSSSLLNAEANRQMKAFARKQNISLIDIDSVKTDSPLYP
LLKAELAHLGKGGNPAAASDLCRWIPELFNEGFYVDIDLPVDSSKIVEGHQITGGVPIMLNMGSIISEPI
APHHRRQEAVCMNTDIIAYSNDKRTQKMMDTVARYLKNIYDDPYTALKDTPLAQTAFFNKCQEERKSIFD
LRKGLQDAFRSDSLLQLYDFLGADKFKEVFKLKEAQSKYINEHISEFSEKDLLLNLISDKPSEISQHTLD
FVKAKAMYIDIAKEHYSAFYKPLVEEISGPGAIYNALGGAGSFTTTHRRLTGPMLPTTPPRVLQVFCDAH
DKGPFVSDNIARWQTNVRDLGVLNREGLSWLPSVG
-
Nucleotide Sequence: 1578 bp     [Download]
>gi|52840256|ref|NC_002942.5|:1513119-1514696 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATGAAAGCAAGAAGGGATCAACAACTCTCTAAATTGCGAATGAGATTTTTTTCAGCGCTCAATCACACAT
CTGAAATTGACTTACAAGTGCTTTTTAATGATTTGAAATCAATTCTCACACTGGATAGTATTGAGCATCT
CAAAGAAGGCTCTGTAGCGTATGCAATCATTCAAGAACTCTTGAAACAGGATGATGCTCAAAATAAGATT
CAATCTTTTTTACATGGAGCGATCAAGAATGTTATTCATCCGGGTGTCATCAAAGGGCTGACCCCTGATG
AAATTAACTGGAATGTTGCCAAAGCATACCCGAAATATTATGAGCATGAGGAATTTCCTGATGTGACTTT
TGGCGGCTTTAAAGTACGTGATAGTAATGAATTTAAATTTAAGACGAATATACAAACTTCGATATGGTTT
AGTATCAAGCCCGATCTTTTCATGCCTTCTAAACAACAGGAGGCTTTAAAAAGAAGAAGGGAACAATACC
CTGGTTGCGAAATTAGATTAATTTATTCCAGTTCATTGCTAAATGCAGAAGCAAACCGCCAGATGAAGGC
ATTTGCCAGGAAACAAAATATTTCATTAATTGATATCGATAGTGTTAAAACCGATTCACCATTATATCCA
TTACTAAAAGCTGAACTTGCACATCTTGGAAAAGGAGGAAATCCTGCTGCTGCCTCCGATCTGTGTCGCT
GGATCCCTGAGTTATTCAATGAAGGGTTTTATGTGGATATTGATCTCCCTGTTGATAGTTCAAAAATAGT
AGAAGGACATCAAATTACAGGAGGAGTTCCAATCATGCTCAATATGGGCTCCATTATCAGTGAACCCATA
GCTCCACATCATAGAAGGCAAGAAGCTGTTTGTATGAATACGGACATTATTGCTTATTCCAATGATAAAA
GAACTCAAAAAATGATGGATACGGTCGCCCGATATTTGAAAAATATATACGATGATCCATATACAGCATT
AAAAGACACACCTCTTGCGCAAACGGCTTTTTTTAATAAGTGCCAAGAGGAAAGGAAAAGTATATTTGAT
TTAAGAAAAGGATTACAAGATGCATTTCGCTCCGATTCATTATTGCAATTATACGACTTTTTAGGGGCAG
ACAAATTTAAGGAAGTATTTAAATTAAAGGAAGCTCAAAGCAAATACATTAATGAGCATATAAGTGAATT
TAGCGAGAAGGATCTGTTGTTAAATTTGATTTCTGATAAACCTTCCGAGATTAGTCAGCATACACTTGAT
TTTGTCAAGGCTAAAGCAATGTACATAGATATTGCCAAAGAGCACTATTCTGCATTCTACAAACCATTAG
TCGAGGAGATTTCAGGGCCAGGTGCCATTTATAATGCTTTAGGAGGAGCGGGCAGCTTCACTACCACTCA
TAGGCGGTTAACAGGACCTATGTTGCCAACAACCCCACCACGTGTTTTACAGGTATTTTGTGATGCACAT
GACAAGGGTCCTTTTGTTTCAGATAATATTGCGCGTTGGCAAACCAATGTTCGAGATCTGGGCGTGTTGA
ATCGAGAGGGTTTGAGTTGGTTGCCTTCAGTAGGGTAG

Reference
(1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890]
(2) Tzivelekidis T; Jank T; Pohl C; Schlosser A; Rospert S; Knudsen CR; Rodnina MV; Belyi Y; Aktories K (2011). Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases. PLoS One. 6(12):e29525. [PudMed:22216304] experimental
(3) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602]
(4) Fontana MF; Banga S; Barry KC; Shen X; Tan Y; Luo ZQ; Vance RE (2011). Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 7(2):e1001289. [PudMed:21390206] experimental
(5) Hurtado-Guerrero R et al. (2010). Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase. Biochem J. 426(3):281-92. [PudMed:20030628] experimental
(6) Belyi Y et al. (2008). Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila. J Bacteriol. 190(8):3026-35. [PudMed:18281405] experimental
 
experimental experimental literature