| Effector Protein ID: 52841203 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg0968 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1061065..1062786 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | SidK |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidK interacts with VatA, a key component of the proton pump, leading to the inhibition of ATP hydrolysis and proton translocation. When delivered into macrophages, SidK inhibits vacuole acidification and bacterial killing. (Xu et al., 2010) |
| UniProt ID | Q5ZWW6 |
| KEGG ID | lpn:lpg0968 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 573 a.a. [Download] |
| >gi|52841203|ref|YP_095002.1| hypothetical protein lpg0968 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MSFIKVGIKMGGLTSEQYHSQVVGKIGYIARCMQTIDPENNLKKIREDYQDVLIWAEKNYRFEEILEASK SGKCPNDLDALSRRSLILQELLRLVSSISPFKMKLDLIESQYEKMKQHVNLWKSDYHVKLNQLNQLTDYL KNAAPTPKNNFLRAMTSVLQMQIAQYGITEDNEGINQLFKLGLHLLAMANEKIDEQYHLFKGYVKDQPEE SPFEGILPAEDQKILVKTMIDYAMPKLSSKVLQDKLSALSSSDVLTKTLLDSIDRIVKENEKLNALSKVK LGKFGLDIREIEVIYSQALKISPQDALQYTAQQCDAQLLSMAFPDSQNYIIESISNKKVKTIAELIHSKE FIYQIIKTEVFKQVDPNEKIRLQAATELYQLLGRIMDKQINLFTKMNLEQINEYIQTKTKAILDKIPERV ELLTFMGFEIPTFKGIETLMTDISHSQDNETLAIAQEFYTNIKNAKNQLLGDKLIEDITPQDVEKFFNQC SQYGSEAAEKLADNRPVLTKIADILTAIARWAISLIGFNTPPQFLAPTRTCVDQVSDEITKIKLKLEDTL GSLQKVQEESLSL |
| - |
| Nucleotide Sequence: 1722 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c1062786-1061065 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGTCTTTTATCAAGGTAGGTATAAAAATGGGTGGCTTAACTAGCGAGCAATATCATAGTCAAGTAGTCG GTAAAATCGGATATATCGCCAGATGCATGCAAACTATAGATCCTGAAAATAATTTGAAAAAAATAAGGGA AGATTACCAAGATGTATTGATATGGGCAGAGAAAAATTATCGTTTTGAGGAAATATTGGAAGCCAGCAAA TCTGGAAAATGCCCTAATGATCTGGATGCATTAAGTCGACGATCGCTAATACTCCAAGAATTGCTGCGGC TTGTTTCATCAATTAGTCCCTTTAAAATGAAATTAGACCTGATTGAGTCTCAATATGAGAAAATGAAGCA GCATGTGAATTTATGGAAAAGTGATTACCATGTAAAACTAAATCAACTGAATCAATTAACAGATTACCTC AAAAATGCAGCACCAACTCCTAAAAATAATTTTCTAAGAGCAATGACCTCTGTATTGCAGATGCAGATAG CCCAATATGGGATTACAGAAGATAATGAAGGCATCAACCAGTTGTTTAAACTGGGATTGCATTTGCTCGC AATGGCTAACGAAAAAATAGATGAACAATATCACCTGTTTAAAGGGTATGTAAAAGATCAGCCTGAAGAA TCTCCTTTTGAAGGTATTTTGCCTGCGGAAGACCAGAAAATTTTAGTTAAAACTATGATAGATTATGCAA TGCCGAAGCTTTCAAGCAAGGTTTTACAAGATAAATTATCGGCACTATCCAGTTCTGATGTATTAACAAA AACATTACTTGATAGCATCGACAGAATTGTTAAAGAAAACGAAAAATTAAATGCTTTAAGCAAAGTCAAA TTAGGTAAATTTGGCCTGGATATCAGGGAAATTGAAGTGATTTACTCTCAAGCTCTGAAAATATCACCAC AAGATGCTTTGCAATATACTGCTCAACAATGTGATGCCCAATTATTAAGCATGGCATTTCCTGATTCCCA AAATTACATTATTGAATCTATATCGAACAAAAAGGTCAAGACCATTGCAGAGCTAATCCATAGTAAAGAA TTTATTTATCAAATTATTAAGACAGAAGTTTTTAAACAAGTTGATCCTAATGAGAAAATTCGACTACAAG CTGCGACAGAATTGTATCAGCTTCTTGGGAGAATAATGGATAAACAGATTAATCTTTTTACCAAGATGAA TCTCGAACAAATTAATGAATATATTCAAACCAAAACCAAAGCAATCCTGGACAAAATTCCTGAAAGAGTT GAGTTATTAACTTTTATGGGCTTTGAAATTCCAACTTTCAAGGGAATTGAGACACTTATGACCGACATCT CCCATTCTCAGGATAATGAAACTCTGGCGATAGCCCAAGAATTTTATACAAATATAAAAAATGCAAAGAA CCAATTGTTGGGTGATAAACTGATTGAAGACATTACTCCACAGGATGTAGAGAAATTTTTTAATCAATGT AGTCAATACGGTTCAGAAGCAGCTGAAAAGTTAGCTGACAATCGTCCGGTATTGACAAAAATAGCCGATA TTTTGACAGCCATTGCCCGTTGGGCGATTAGTTTAATAGGTTTCAATACGCCACCGCAGTTTTTGGCTCC AACCAGAACCTGTGTGGATCAGGTATCTGATGAAATCACTAAAATTAAACTCAAACTTGAAGATACTTTG GGAAGCTTGCAAAAAGTACAGGAAGAAAGCCTAAGCCTTTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (2) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
(3) Xu L; Shen X; Bryan A; Banga S; Swanson MS; Luo ZQ (2010). Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector. PLoS Pathog. 6(3):e1000822. [PudMed:20333253] 
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| experimental literature |
| in silico analysis literature |