| Effector Protein ID: 52841175 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg0940 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1017170..1019359 [-] |
| Product | LidA |
| Effector type | Protein |
| Descripton | LidA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LidA may be involved in vesicle recruitment during the biogenesis of the replication vacuole |
| UniProt ID | Q5ZWZ3 |
| KEGG ID | lpn:lpg0940 |
| PDB ID | 3TNF |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 729 a.a. [Download] |
| >gi|52841175|ref|YP_094974.1| LidA [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MAKDNKSHQVKTSEGSLESVKTKEKEPVLEKMRVEDSKKEDKLSMPTTKKESQPNEPVKPFKTSFEKWIE SSLLDPQAKEDRGSTINLGREGLKNASQVKKFLLSPAGKDVIAELGAQMALQRNINLQNQQDRMEHELFK RRLMAALFLWYLSKKSHAAEKVKEIIREYNEKAIKNAEKASKPSQQSTSSTSQADKEIQKMLDEYEQAIK RAQENIKKGEELEKKLDKLERQGKDLEDKYKTYEENLEGFEKLLTDSEELSLSEINEKMEAFSKDSEKLT QLMEKHKGDEKTVQSLQREHHDIKAKLANLQVLHDAHTGKKSYVNEKGNPVSSLKDAHLAINKDQEVVEH EGQFYLLQKGQWDAIKNNPAALEKAQKDYSQSKHDLATIKMEALIHKLSLEMEKQLETINNLIMSTDPKE NEEATKLLHKHNGLNLKLANLQDMLAVHRKEKSFFNEKGEEVTSLNDAHYVIGKDQQLFNLGGKFYPIHK EQKILEKDGKFYLLKQGEDWESIKDSPEKQKKAEHDFHKLQYETPMTVKKLVHHNKGLETTIHKERVEET KQQLEDNGKEKIEIANNISKLQSTVGVALNQLNQPTLDTESPVLTPSGGSTTSSPKPTPSLASVTTFFKT KIDEMKKNENVKVTFDDLLALSIKIADPKARTYFTGELLKEVPRSGAIPFQTMQRMLQTLEQYGVDTTKP SVTSIRSKTDEVLEQRFNPTPSLSPFKTS |
| - |
| Nucleotide Sequence: 2190 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c1019359-1017170 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGGCAAAAGATAACAAATCACATCAAGTTAAAACATCAGAAGGGAGTCTTGAATCCGTAAAAACCAAGG AAAAGGAACCTGTTTTAGAAAAAATGCGTGTTGAGGATAGTAAAAAAGAAGATAAGCTATCAATGCCCAC CACTAAAAAAGAATCTCAACCCAATGAGCCAGTCAAGCCCTTTAAAACTTCTTTTGAGAAATGGATAGAA TCCAGCTTGCTTGATCCACAGGCTAAGGAAGACAGAGGCTCCACCATTAATCTGGGCCGAGAAGGGTTAA AAAACGCATCCCAGGTCAAAAAATTTCTTTTATCTCCGGCGGGTAAAGACGTAATAGCTGAATTAGGCGC CCAAATGGCTCTGCAAAGAAACATCAATCTACAAAATCAACAAGACAGAATGGAGCATGAGCTCTTTAAA CGCCGATTAATGGCCGCATTGTTTTTGTGGTATTTATCCAAAAAATCCCATGCTGCGGAAAAAGTCAAAG AAATTATTCGGGAATACAATGAAAAAGCCATAAAAAATGCTGAAAAAGCAAGCAAGCCAAGCCAACAGTC CACTTCATCCACTTCGCAAGCTGATAAAGAAATTCAAAAAATGCTGGATGAATATGAACAAGCTATTAAA CGTGCTCAAGAGAATATTAAGAAAGGCGAAGAATTAGAAAAAAAACTGGATAAGCTGGAACGTCAAGGCA AAGATCTTGAAGACAAGTACAAAACCTATGAAGAAAATTTGGAAGGGTTTGAAAAACTTCTCACTGATTC TGAAGAGTTATCACTATCCGAAATTAATGAAAAAATGGAAGCCTTCAGCAAAGACAGTGAGAAACTCACT CAACTGATGGAAAAGCATAAAGGCGATGAGAAAACCGTTCAATCCTTACAGCGTGAGCATCATGACATAA AAGCAAAACTGGCTAACCTGCAAGTTTTGCATGACGCTCATACAGGTAAAAAATCCTATGTTAACGAAAA AGGAAACCCGGTCAGCTCATTAAAAGACGCGCACCTGGCCATTAATAAAGACCAGGAAGTAGTAGAACAT GAAGGACAATTCTATCTCCTGCAAAAAGGTCAATGGGATGCCATTAAGAATAATCCTGCAGCATTAGAAA AAGCCCAAAAAGACTATAGCCAATCTAAACATGATCTTGCAACCATCAAGATGGAAGCTCTAATTCATAA GCTTAGTTTGGAAATGGAAAAACAATTGGAAACAATAAATAATCTTATTATGAGCACAGATCCCAAAGAA AACGAGGAAGCCACCAAATTGCTGCATAAACATAATGGATTAAATTTAAAATTGGCAAATCTACAAGATA TGCTTGCAGTACATAGAAAAGAAAAATCCTTTTTTAATGAGAAAGGAGAGGAAGTGACATCATTAAATGA TGCGCATTACGTGATAGGTAAAGATCAACAACTGTTTAATTTAGGCGGTAAATTCTATCCTATCCATAAA GAACAAAAAATACTTGAAAAAGACGGCAAATTTTATCTTTTAAAACAAGGTGAAGACTGGGAATCTATCA AAGACAGTCCGGAAAAACAAAAAAAAGCTGAGCATGATTTTCATAAACTTCAGTATGAAACACCAATGAC CGTCAAGAAATTAGTACATCATAATAAAGGTTTAGAAACAACCATTCATAAAGAAAGAGTTGAAGAGACG AAACAACAATTAGAAGACAATGGAAAAGAAAAAATAGAAATAGCCAATAACATAAGTAAACTTCAATCTA CAGTTGGTGTGGCTTTAAATCAACTCAACCAACCAACTTTAGATACTGAATCACCTGTCTTAACACCTTC TGGAGGAAGTACAACCAGTTCACCGAAACCAACCCCGAGCTTGGCGTCAGTGACTACTTTTTTCAAGACG AAGATAGATGAAATGAAAAAAAATGAAAATGTTAAAGTTACCTTTGATGATCTGCTGGCGCTCAGTATTA AAATTGCCGATCCAAAAGCGCGTACTTATTTTACTGGTGAACTACTTAAGGAAGTGCCGCGCTCTGGAGC AATACCGTTTCAAACTATGCAACGTATGCTGCAAACTCTTGAGCAATATGGGGTAGATACTACAAAACCC AGTGTTACTTCTATAAGAAGCAAAACAGATGAAGTCCTTGAGCAACGATTTAACCCTACCCCGTCTTTAT CTCCATTCAAGACATCATAA |
| Reference |
(1) Goody PR; Heller K; Oesterlin LK; Muller MP; Itzen A; Goody RS (2012). Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J. 31(7):1774-84. [PudMed:22307087] 
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(2) Neunuebel MR; Mohammadi S; Jarnik M; Machner MP (2012). Legionella pneumophila LidA affects nucleotide binding and activity of the host GTPase Rab1. J Bacteriol. 194(6):1389-400. [PudMed:22228731]
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(3) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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(5) Machner MP; Isberg RR (2006). Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. Dev Cell. 11(1):47-56. [PudMed:16824952]
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| (6) Bourzac KM; Guillemin K (2005). Helicobacter pylori-host cell interactions mediated by type IV secretion. Cell Microbiol. 7(7):911-9. [PudMed:15953024] |
| experimental literature |
| in silico analysis literature |