| Effector Protein ID: 52840933 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg0696 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 758172..759884 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | Lem3 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Lem3 reverses AnkX-mediated modification on Rab1 as a dephosphorylcholinase (Tan, et al, 2011) |
| UniProt ID | Q5ZXN5 |
| KEGG ID | lpn:lpg0696 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 570 a.a. [Download] |
| >gi|52840933|ref|YP_094732.1| hypothetical protein lpg0696 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKLRYIINENKLVFTSCNMRDKIITGKKIIFSQSVAKDQTKNLSSFLSERFYSVNQSHNHSIIIGSSLSH QENDIEHDTILDTSGVLVTTDTNGIVNGARVAITDGLGGGNGDQEEDDEIYRVSHSSCENFLNCDQNIDT TLSLITQPKASDKKQTAPKTLQHTEASMAAFIYQNHPGKGYIGEFANIGDGLIIILDKRFKIKHMVSACH IYRGFGTWTPPSLQALATTANKDALLVRQTLKLAEGDIIISMTDGVWGELKTSLIAQTNDRRDIGVDKEY FKTLFDELTDAPYPSSFDIARIITQRAMSRSLERRKTLIKLINEIEQQHFHEKSVKTINEVLEYFIKTGH VETAQTLKAILFEDGLSDGITYFENIEIPLEMVMHDLKSRTVGDCSTINVTRIPYHLDELIRGFINYPEK HQILAPLFKARVKSEADLEEAFHRLSLEMVQPEIECPISETHFERAFKKETLDKTQAVLTHYFRISTGLD SKKNYQERLNDLSAYLSKESSLEKNDIKLLLSMLDSEIKPKTGVFQTLFGENQNKLYKAFHKKIELQLLD SEIENKNELK |
| - |
| Nucleotide Sequence: 1713 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c759884-758172 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAAGTTACGCTATATTATTAATGAGAATAAGCTTGTTTTTACGAGTTGCAATATGAGAGATAAAATTA TCACTGGGAAAAAAATTATTTTTTCACAATCCGTTGCAAAAGACCAAACAAAAAATTTATCAAGCTTTTT ATCAGAACGGTTTTACTCTGTAAATCAAAGCCATAATCATTCCATTATTATCGGTTCCAGTCTTTCTCAC CAAGAGAATGATATCGAACACGATACCATACTCGATACATCAGGCGTGTTAGTGACTACTGATACAAATG GCATCGTTAACGGAGCAAGAGTCGCAATTACTGACGGTCTGGGTGGTGGAAATGGCGATCAGGAAGAAGA CGACGAGATATACAGAGTATCTCATTCCAGTTGCGAGAATTTTTTGAATTGCGACCAAAATATAGATACG ACTCTAAGCTTGATTACCCAACCAAAGGCCTCTGATAAAAAACAAACAGCACCGAAAACGTTGCAGCATA CAGAAGCGTCGATGGCTGCTTTTATTTATCAAAATCATCCGGGAAAAGGATACATAGGTGAATTTGCAAA TATTGGTGATGGACTAATTATTATCCTGGATAAACGTTTTAAAATAAAACATATGGTATCCGCATGCCAT ATATATCGCGGATTTGGTACCTGGACACCACCATCCCTGCAAGCCCTGGCAACAACTGCAAATAAAGACG CCCTGCTTGTCAGACAAACACTTAAACTTGCAGAAGGCGACATTATAATATCAATGACTGATGGGGTTTG GGGGGAGCTGAAAACCAGTTTGATTGCTCAAACCAATGACCGTCGAGATATAGGAGTAGATAAAGAATAT TTCAAAACGCTATTTGACGAATTGACAGATGCTCCCTACCCATCTTCATTTGATATCGCTCGTATCATTA CCCAGCGCGCCATGTCTCGCAGTTTGGAGCGTAGAAAAACGTTAATAAAATTAATTAATGAAATAGAACA ACAACACTTCCATGAAAAATCTGTCAAAACCATTAATGAAGTCCTGGAATATTTTATTAAAACAGGCCAT GTGGAAACAGCACAGACATTAAAAGCAATTCTCTTTGAAGACGGTTTGAGTGATGGAATAACTTATTTTG AAAATATTGAAATCCCGCTGGAGATGGTAATGCACGATTTAAAAAGTCGTACCGTCGGTGATTGTTCAAC CATCAATGTAACGCGCATTCCCTATCATTTAGATGAGCTCATACGAGGTTTTATCAATTACCCTGAGAAA CATCAAATCCTGGCGCCACTATTTAAAGCAAGGGTAAAATCTGAGGCTGATTTAGAAGAGGCATTTCATC GTCTGTCACTTGAAATGGTACAACCTGAAATCGAGTGCCCAATTTCTGAAACTCATTTTGAACGTGCTTT TAAAAAAGAAACCCTTGATAAAACTCAGGCTGTCTTAACTCACTATTTTCGTATTTCGACTGGTTTAGAT AGTAAAAAAAATTATCAGGAACGATTAAATGATCTGAGTGCTTACTTATCTAAGGAATCCTCTCTCGAAA AAAATGATATTAAATTGCTATTATCCATGCTAGATAGTGAAATAAAACCTAAAACCGGGGTTTTCCAAAC ATTGTTTGGGGAAAACCAAAATAAATTATACAAGGCATTTCACAAAAAAATCGAGTTGCAATTATTGGAT AGTGAAATAGAAAATAAAAATGAATTGAAATAG |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Goody PR; Heller K; Oesterlin LK; Muller MP; Itzen A; Goody RS (2012). Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J. 31(7):1774-84. [PudMed:22307087] 
|
(3) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
|
|
(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
|
| experimental literature |
| in silico analysis literature |