| Effector Protein ID: 52840932 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legA8 |
| Locus tag | lpg0695 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 755316..758165 [+] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | AnkN/ankX legA8 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkX modified both Rab1 and Rab35 by cAMP(Fic) domain-dependent manner (Mukherjee, et al, 2011) |
| UniProt ID | Q5ZXN6 |
| KEGG ID | lpn:lpg0695 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 1.4e-46, Aligned region: 372..443 Ank_2 [PF12796], Evalue: 1.4e-46, Aligned region: 445..527 Ank_2 [PF12796], Evalue: 1.4e-46, Aligned region: 561..632 Ank_2 [PF12796], Evalue: 1.4e-46, Aligned region: 643..714 Ank_4 [PF13637], Evalue: 1.2e-35, Aligned region: 394..440 Ank_4 [PF13637], Evalue: 1.2e-35, Aligned region: 622..679 Ank [PF00023], Evalue: 2.9e-32, Aligned region: 392..422 Ank [PF00023], Evalue: 2.9e-32, Aligned region: 424..441 Ank [PF00023], Evalue: 2.9e-32, Aligned region: 590..619 Ank_5 [PF13857], Evalue: 8.5e-32, Aligned region: 392..432 Ank_5 [PF13857], Evalue: 8.5e-32, Aligned region: 588..628 Fic [PF02661], Evalue: 1.6e-07, Aligned region: 177..238 |
| Protein Sequence: 949 a.a. [Download] |
| >gi|52840932|ref|YP_094731.1| ankyrin repeat-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MVKIMPNLPGLYFLQAYPSEEIWRLFVDGRFWSKENGWRGYESREPGCLNAALESLCSIALQVEKSGEEF ELSVDLIKRIHKKCGKKVEELQEKNPGELRTDEPVSFGIPAGRASIKGIEEFLSLVFLTEGGAEFGPGKA GPFGPRFDKNYFKNLNPEQIPDLAKQIYFDMCKYGHSNTNHFYLAVMKNVDVYLEKITQSYNKEIKTAET LDEKLKIIVKHIRMYEVLHPFRDANGRTFVNNLLNILLMQQGLPPATFYEPNVFDLYSAEELVVVVKEAI FNTVEIIEQSKRKTPITLYGYHSSLEEQTKFRDMLDSPSYEKIKHMDFSDLNPEKLHLKTQKCLSSLNEQ YPLHRGAIYLSDPGEIKLLLSNRNESQINQQIEQGAPPIYVGKTPAHLAVISGNMAMLDELIAKKADLSL QDYDGKTALHYAAECGNMQIMGKILKVVLSQEDAIKVLNIKDNHGKTAFHYAAEFGTPELISALTTTEVI QINEPDNSGSSAITLAYKNHKLKIFDELLNSGADISDELLDAIWARKDKETLGKIIAKNEKILLNKEAFR IAISLGSVSLVKKFLRAGVDIDIPLTKDKATPLMLSINSGNPKLVSYLLKKGANTRLTDTSGNSVLHYVF YSKAENREALANIITEKDKKLINQPNANGNPPLYNAVVVNDLKMATILLEMGARVDFEDRLGNNILHSAM RRCDLPIILDIVKKDSTLLHKRNSERRNPFHQALHEMHTFPSSKETEEIHFMNLSDLLLKEGVDLNKKDI KGKTILDIALSKQYFHLCVKLMKAGAHTNISSPSKFLKNSDANSILERPFKFKNDLKKELDNNPLIAMAQ INDLYVQIKNNRIRTPTGYAPKEGVSFFKGKSNDAKAHDEVLSVLKELYDSKLTEMLGNLPGEGLEEIKR SQKFFDGELKLLIKNQDISRKVDKKSIQEAVGTSLKLKW |
| - |
| Nucleotide Sequence: 2850 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:755316-758165 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGGTAAAAATTATGCCAAATCTACCTGGATTATATTTTCTTCAAGCCTATCCAAGCGAAGAAATATGGA GATTATTTGTTGATGGGCGCTTCTGGTCAAAAGAAAATGGATGGAGAGGCTATGAGTCGCGAGAGCCAGG ATGCCTTAACGCCGCTCTGGAGAGTTTATGTTCTATTGCATTGCAAGTTGAGAAATCAGGAGAGGAATTT GAATTAAGCGTTGATTTAATAAAGAGGATACACAAGAAGTGTGGAAAAAAGGTGGAGGAATTACAGGAAA AAAATCCAGGTGAACTCAGAACAGATGAACCTGTTTCATTTGGCATTCCAGCTGGCCGGGCCTCGATTAA GGGTATTGAAGAATTCCTGAGCCTGGTATTTCTTACAGAAGGTGGAGCTGAATTTGGCCCAGGCAAAGCG GGTCCATTTGGCCCACGCTTTGATAAGAACTATTTTAAAAATCTGAATCCAGAACAAATACCTGATCTTG CCAAGCAAATCTATTTCGATATGTGCAAATATGGGCATAGTAATACCAATCACTTCTATCTTGCCGTGAT GAAAAATGTGGATGTTTACCTGGAAAAAATTACCCAATCTTACAACAAGGAAATAAAAACCGCCGAAACT CTTGATGAAAAACTTAAAATTATCGTTAAGCATATTCGAATGTACGAAGTATTACACCCTTTTCGAGATG CCAATGGCCGTACCTTTGTCAATAATTTATTAAATATTCTTTTAATGCAACAAGGTTTACCGCCAGCGAC GTTTTACGAACCTAATGTCTTTGATTTATATAGCGCTGAGGAATTAGTTGTTGTTGTGAAGGAGGCAATT TTTAATACGGTAGAAATTATTGAACAAAGTAAAAGAAAGACTCCCATTACTTTATATGGATATCATTCAA GCTTGGAAGAGCAAACCAAATTTCGGGACATGCTGGATAGCCCATCGTATGAAAAAATCAAACATATGGA TTTTTCAGATTTAAACCCTGAGAAACTGCATCTGAAGACTCAAAAATGTTTATCATCATTAAATGAGCAA TATCCATTACACAGAGGCGCAATCTATCTTAGTGATCCTGGTGAGATAAAATTATTATTGTCAAATCGCA ATGAATCCCAGATTAATCAGCAGATAGAGCAAGGAGCACCGCCTATTTATGTCGGTAAAACTCCTGCTCA TTTGGCTGTCATATCAGGAAATATGGCAATGCTTGATGAGCTTATCGCAAAAAAAGCGGATTTATCTCTT CAGGATTATGATGGAAAAACTGCTCTTCACTATGCTGCGGAGTGTGGAAATATGCAAATTATGGGAAAAA TACTAAAAGTTGTGCTAAGCCAGGAAGATGCCATCAAAGTACTGAATATCAAGGATAATCATGGCAAAAC AGCATTCCATTATGCTGCTGAGTTTGGAACCCCGGAATTAATATCAGCCTTGACAACCACAGAGGTTATT CAGATTAATGAACCGGATAACAGCGGTTCTTCAGCAATCACTTTGGCATATAAAAATCATAAATTGAAAA TTTTCGATGAACTATTAAATTCCGGTGCTGATATCAGTGATGAGCTTTTGGACGCGATATGGGCTCGGAA GGATAAAGAGACATTAGGTAAAATAATTGCCAAAAATGAGAAAATTCTTTTGAATAAAGAAGCCTTCAGG ATAGCTATTTCTTTAGGAAGTGTCAGTCTGGTTAAAAAATTTTTACGTGCCGGGGTCGATATTGATATAC CCTTAACCAAAGATAAAGCAACACCGCTAATGTTATCTATAAATTCCGGTAATCCCAAATTGGTCAGTTA TTTATTGAAAAAAGGAGCTAATACACGTTTAACCGATACCAGTGGCAATTCTGTCCTGCATTATGTTTTT TATTCAAAGGCAGAAAACAGGGAAGCTTTAGCAAATATTATAACTGAGAAAGATAAGAAATTAATTAATC AGCCAAATGCTAATGGAAATCCACCTCTTTATAATGCTGTGGTAGTTAATGATTTGAAAATGGCAACAAT TTTATTAGAAATGGGGGCAAGGGTCGATTTCGAAGACAGGCTGGGAAATAATATTTTGCATAGTGCCATG AGAAGATGTGATTTGCCGATTATATTGGATATTGTCAAGAAAGATAGCACCTTACTTCATAAAAGAAACT CTGAAAGAAGAAATCCTTTTCATCAGGCATTGCATGAGATGCATACGTTTCCATCCTCAAAAGAAACCGA AGAAATACACTTCATGAATTTAAGTGATTTACTTTTAAAAGAAGGAGTCGATTTAAATAAAAAAGATATT AAAGGAAAAACAATATTAGATATCGCATTATCCAAGCAGTATTTTCATTTATGTGTCAAACTGATGAAAG CAGGTGCCCATACCAATATATCTTCTCCATCAAAATTTCTTAAAAACTCCGATGCCAATTCTATTTTGGA ACGTCCTTTTAAATTTAAGAACGATTTAAAAAAAGAGCTCGATAATAATCCGCTAATTGCTATGGCACAA ATTAATGATTTGTACGTCCAAATCAAAAATAACAGGATTAGGACTCCTACAGGTTATGCCCCGAAAGAAG GAGTATCCTTTTTTAAAGGAAAATCAAACGATGCCAAAGCACATGATGAGGTTTTATCTGTTTTAAAGGA ACTCTACGACAGTAAACTCACTGAGATGCTCGGTAATCTTCCTGGAGAAGGATTAGAAGAAATCAAAAGA AGCCAGAAATTTTTTGACGGCGAACTAAAATTATTAATTAAAAACCAGGACATTTCGAGGAAAGTCGATA AAAAGTCTATTCAGGAAGCAGTTGGTACATCCTTGAAATTAAAATGGTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Goody PR; Heller K; Oesterlin LK; Muller MP; Itzen A; Goody RS (2012). Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J. 31(7):1774-84. [PudMed:22307087] 
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(3) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (4) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
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(5) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |