| Effector Protein ID: 52840728 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legA12 |
| Locus tag | lpg0483 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 522033..523520 [+] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | AnkC/legA12 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZY89 |
| KEGG ID | lpn:lpg0483 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 495 a.a. [Download] |
| >gi|52840728|ref|YP_094527.1| ankyrin repeat-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MDFVSEMNKILQMELEQFKEFIQKKLEEDKNYLEKLFWLPNGSQMTVLNYLIEQYSEPKLGIDDANRDLL AKIDFVLHEAKDVNVGEPLHQAIVAGKISLALHLLGVDENNFTPGESEKTDVLSILSKVRKKIEESFNHV KRCFFDVDKRDGYGRTLLSLALDAKRQELLIAILARNPIVHATTLRSSAYVPFQPIHQAVVLDYAEGITL LASMGAQLTNPLGSMRDTPVILAARLGKINALAALLELPTQSLSLESENNHLFEDKQTGHTAVEELCERM ANENDKADALRGIAMLICRGAEPPRNEKMRNLLSSNRVAFLKAVSTYLADKPQLVDAFVERCHLRESALH NIVYADHSWGSSIRHLLGVPSEAALIVEELVTRKYSDPSFASENVSSLSTTATENLRSERNPLKLYAEFV RRYTQAYDSQMITNRWSTMRWMIAEGNCDWDTVVRYSKNHPTSRTRIVLNEMFNPIPRVHEDIESQQSSP RVVLK |
| - |
| Nucleotide Sequence: 1488 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:522033-523520 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGGATTTTGTAAGTGAAATGAATAAGATTCTACAAATGGAATTAGAGCAATTTAAAGAATTTATTCAAA AGAAGCTGGAAGAAGATAAAAATTATTTAGAAAAGTTATTTTGGTTGCCGAATGGTTCTCAAATGACCGT TTTAAATTATTTGATCGAACAATACTCTGAGCCTAAGCTTGGTATAGACGATGCAAATAGGGATTTGCTT GCCAAAATAGATTTTGTCCTTCACGAGGCTAAAGATGTGAATGTTGGTGAGCCCTTGCACCAGGCAATTG TTGCTGGAAAAATTTCCTTGGCGCTCCATCTGCTGGGAGTGGATGAAAATAATTTCACACCCGGGGAGAG TGAAAAAACGGATGTTTTGAGTATTTTGTCTAAAGTAAGGAAAAAAATCGAAGAGTCTTTTAATCACGTA AAAAGATGTTTTTTTGATGTGGATAAACGGGATGGTTATGGGCGCACTTTGTTGTCTTTGGCATTAGATG CCAAACGCCAGGAACTGTTAATTGCCATTTTAGCCAGAAATCCCATTGTACACGCGACAACGTTAAGATC CTCAGCCTATGTTCCTTTCCAGCCTATTCATCAGGCTGTTGTTTTAGATTATGCAGAGGGCATTACCTTA TTAGCCAGCATGGGGGCGCAATTGACAAATCCCCTGGGTAGCATGAGAGACACTCCGGTCATTTTGGCCG CTCGTTTGGGCAAAATAAATGCACTGGCGGCTTTACTGGAGTTACCAACTCAAAGTTTGTCTCTTGAATC CGAAAACAATCATTTATTCGAAGACAAACAAACTGGCCATACAGCAGTGGAAGAGTTATGTGAACGCATG GCCAATGAGAATGATAAAGCAGACGCTCTTCGTGGGATTGCCATGCTAATATGCCGTGGCGCTGAACCAC CCCGTAATGAAAAAATGCGAAATTTGTTAAGCAGCAACCGGGTTGCTTTCTTAAAAGCGGTCAGTACCTA TTTGGCAGATAAGCCTCAATTGGTCGATGCTTTTGTGGAGCGTTGTCATCTAAGAGAAAGTGCTTTGCAT AATATAGTTTATGCCGATCATTCATGGGGGAGTTCTATTCGTCATTTACTCGGTGTTCCCAGTGAGGCGG CCCTTATTGTTGAAGAATTAGTGACGAGAAAATACAGTGATCCTTCCTTTGCCAGCGAAAATGTTTCGTC ATTATCAACTACTGCCACGGAAAACCTACGTTCAGAGAGGAACCCACTGAAACTCTATGCCGAATTTGTC AGGCGATACACGCAAGCATATGATAGCCAAATGATTACCAATCGTTGGAGTACCATGCGCTGGATGATCG CCGAAGGAAATTGTGATTGGGATACAGTAGTTCGATATTCGAAAAATCATCCAACGAGCCGTACCAGGAT TGTGTTGAATGAAATGTTTAACCCGATACCGAGGGTACATGAGGATATTGAGTCTCAACAGAGTTCTCCA CGAGTTGTCCTAAAATAA |
| Reference |
(1) Gomez-Valero L et al. (2014). Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease. Genome Biol. 15(11):505. [PudMed:25370836] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |