| Effector Protein ID: 52840682 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg0437 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 474811..476811 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | Ceg14 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZYD5 |
| KEGG ID | lpn:lpg0437 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 666 a.a. [Download] |
| >gi|52840682|ref|YP_094481.1| hypothetical protein lpg0437 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MQNLDEILKKLRKDLKKTSKETTEKLSVLSKKVAEDVVKVSNQTVQKINEVTKKFTVDTTVSTIDTQKIL DDFMKNIRFSRFKQIWQAIEKTPKSKHILLKSLFLKGLLTHNKPLLEEIIRQIELIPYSSDLEMLGAFSQ DKAHPLSPELLEFVQEMLANESEKVLLTILMNAFQSIPELSLDSKTGTLSMKTKKALLPLLIEKVDTSIA KSIMSQLTDISFDSVLPAFRPSIGDPSYQKTNINLNKYLSLVGNKTDISEFLILTIGLFTSLKIGDKGFL QELSADYLFVRYDDCLHKIIEKLKEKEVIEQLGEKEVQKILEASGNLKRFKPTSNNPRRFFETRLAQYIN GLSHSEKTIEIDSIGEDKEPEDEELRDNTLKACNKILQFFLGDCGRVDTPREMEQKICIFANGYKDTSKF TKKEVEFITGVLHHAGAHKGRDRVERDKLTGIKERKFETDSEKVGSDVWNCGGGVMKGCSPVFYDAQRDP MRNMLVDSSTVAPDNKEGKQWFWNNNRQYSSYVGSISGHTCNIVGMLAKYMTEYKEDLDLQNDINLFLIQ VIGVYAKRGFHAMLEVIDVLHDPYVQDIFKGYGVQVNLYSYFKENPELAGFLQHAMNDATTYTQALVNKK HVKEALKSNSFFSKKDEESGDKKNDHTPKDGTVYGC |
| - |
| Nucleotide Sequence: 2001 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:474811-476811 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGCAAAACTTAGATGAGATTCTAAAGAAACTGAGAAAAGATCTGAAAAAGACTTCGAAGGAAACGACTG AGAAGCTCAGTGTTTTATCAAAGAAAGTTGCTGAAGATGTGGTTAAGGTATCCAATCAAACGGTTCAAAA AATTAACGAAGTAACCAAAAAATTCACCGTAGATACTACAGTCAGCACTATTGACACCCAAAAAATTTTA GATGATTTTATGAAAAATATACGTTTTTCTCGATTTAAGCAGATTTGGCAAGCAATTGAGAAAACACCGA AATCCAAGCATATATTGTTAAAATCTCTCTTCTTAAAAGGGCTATTGACTCATAATAAACCTCTACTTGA AGAAATTATACGACAAATTGAATTAATACCTTACTCAAGTGATCTGGAGATGCTCGGTGCTTTTAGTCAG GACAAAGCACATCCGCTCTCACCTGAGCTTCTGGAGTTTGTGCAAGAGATGCTTGCCAATGAAAGTGAGA AAGTATTACTCACTATTCTGATGAATGCTTTTCAGTCTATTCCTGAATTGTCTCTTGATAGCAAGACAGG GACTTTAAGCATGAAAACTAAAAAAGCCTTACTGCCTCTTTTAATTGAAAAAGTGGATACTTCGATTGCA AAATCAATCATGTCACAATTAACTGATATCTCATTTGATTCTGTATTACCCGCATTTCGTCCATCGATTG GTGATCCCAGCTATCAGAAAACGAACATAAACTTGAACAAATACTTGTCTCTAGTTGGTAACAAAACAGA TATTTCAGAATTTTTAATATTAACGATTGGTCTTTTTACTTCCTTAAAAATTGGAGATAAGGGGTTTTTG CAAGAATTATCGGCTGATTATTTATTTGTTCGATATGATGACTGCTTGCATAAAATAATAGAAAAACTAA AGGAAAAAGAAGTAATAGAACAATTAGGAGAAAAAGAAGTTCAAAAAATTCTGGAAGCTTCTGGAAACCT TAAGCGGTTTAAACCGACAAGTAATAACCCAAGACGATTTTTTGAAACTCGCCTTGCTCAGTACATTAAC GGCCTTTCCCACTCAGAAAAGACCATTGAAATTGATTCGATAGGAGAAGATAAAGAGCCTGAAGATGAGG AATTGAGAGATAACACATTGAAGGCATGTAATAAAATTCTGCAATTCTTTTTGGGTGATTGTGGAAGAGT TGATACTCCACGAGAGATGGAACAAAAAATTTGTATCTTTGCCAATGGTTATAAGGATACCTCTAAATTT ACCAAGAAAGAAGTCGAATTTATTACCGGTGTATTACATCATGCTGGAGCGCATAAAGGGCGCGATAGGG TTGAGCGGGATAAATTGACGGGCATTAAAGAAAGAAAATTTGAGACTGACTCAGAAAAAGTAGGTTCAGA TGTATGGAATTGTGGCGGTGGAGTCATGAAAGGCTGTTCGCCTGTCTTTTATGATGCCCAACGCGACCCC ATGCGTAATATGCTAGTGGATTCATCGACTGTTGCGCCTGATAACAAAGAGGGAAAACAATGGTTTTGGA ATAATAACCGCCAGTATTCGTCTTACGTAGGATCGATTTCCGGGCATACTTGTAATATTGTAGGTATGTT AGCCAAGTATATGACAGAATATAAAGAAGATCTCGATCTGCAAAACGACATCAATCTTTTTCTTATTCAG GTAATCGGTGTTTATGCCAAGCGTGGTTTTCATGCCATGCTTGAGGTCATTGATGTTCTTCATGATCCTT ATGTACAAGACATATTCAAAGGATATGGTGTTCAAGTTAACCTTTATAGCTATTTTAAAGAAAACCCTGA GCTTGCTGGATTCCTGCAGCATGCGATGAATGATGCAACCACTTATACTCAGGCTCTTGTTAATAAGAAG CATGTTAAGGAAGCACTCAAATCAAATTCATTCTTCAGTAAGAAAGACGAAGAGAGTGGAGATAAGAAAA ACGACCATACGCCAAAAGATGGAACTGTTTATGGGTGCTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (2) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
(3) Fontana MF; Banga S; Barry KC; Shen X; Tan Y; Luo ZQ; Vance RE (2011). Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 7(2):e1001289. [PudMed:21390206] 
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(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |