| Effector Protein ID: 52840681 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legA11 |
| Locus tag | lpg0436 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 473739..474548 [-] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | AnkJ/legA11 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkJ is required for intracellular replication |
| UniProt ID | Q5ZYD6 |
| KEGG ID | lpn:lpg0436 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 2.1e-09, Aligned region: 19..114 Ank_4 [PF13637], Evalue: 6.8e-07, Aligned region: 65..106 |
| Protein Sequence: 269 a.a. [Download] |
| >gi|52840681|ref|YP_094480.1| ankyrin repeat-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MIKMGRSEMKIASAELRELMKAVSEGHYETVNTILDKDPELVNQYAPPTYDSPLARVLNKKHIDYKMLDI LVKHHVDFDYPINYHKETPIELACKNQDLQLFKYLVQHNAPISEQAPHFLLVNSTNIKYLTEDKIKNTCE IIKLMGGLEAVSSKCDAEGNRFGEQARKSQLINRFGGIVKYDYMQLLQSVYPIVDREVDAPTIHGSTEVL TNLLNKIRGQFSSKETYDQQNLKDSISLFFMTGGEIPPSRKVPESRFEEAGIDTPKNAL |
| - |
| Nucleotide Sequence: 810 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c474548-473739 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome GTGATTAAAATGGGTAGAAGTGAAATGAAAATAGCATCAGCTGAATTGCGTGAATTGATGAAGGCAGTAT CTGAAGGTCATTATGAAACTGTCAATACTATACTGGATAAAGATCCTGAGCTTGTAAATCAGTACGCCCC CCCCACTTATGATTCACCCCTGGCTAGAGTATTAAATAAAAAACACATTGACTACAAAATGCTTGATATT TTGGTTAAGCACCATGTTGATTTTGATTATCCTATCAACTATCACAAAGAGACACCAATTGAATTGGCTT GTAAAAATCAGGATCTTCAATTATTCAAGTACTTAGTCCAACACAATGCCCCCATTTCAGAACAAGCACC ACATTTCCTGCTGGTGAATAGCACCAATATCAAATACCTGACTGAAGATAAAATTAAAAACACCTGTGAA ATTATTAAATTAATGGGTGGTTTGGAAGCTGTTTCTTCTAAATGTGATGCTGAAGGTAATCGCTTTGGAG AACAAGCAAGGAAATCACAATTAATCAATCGCTTCGGTGGTATAGTAAAGTACGATTACATGCAATTGCT GCAATCAGTTTATCCAATTGTTGATAGAGAAGTAGATGCTCCAACCATCCATGGCTCTACTGAAGTACTT ACCAATCTGCTCAATAAAATTAGGGGGCAGTTCAGCTCAAAAGAAACATACGATCAACAAAATTTAAAAG ATTCCATTAGTCTTTTCTTTATGACCGGTGGAGAAATACCTCCTTCAAGAAAAGTTCCAGAGAGTCGTTT TGAAGAAGCTGGCATAGATACCCCTAAAAACGCACTTTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Altman E; Segal G (2008). The response regulator CpxR directly regulates expression of several Legionella pneumophila icm/dot components as well as new translocated substrates. J Bacteriol. 190(6):1985-96. [PudMed:18192394]
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| experimental literature |
| in silico analysis literature |