| Effector Protein ID: 52840648 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legA7 |
| Locus tag | lpg0403 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 443204..444748 [+] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | AnkG/ankZ/legA7 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZYG9 |
| KEGG ID | lpn:lpg0403 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 3.3e-16, Aligned region: 313..404 Ank_2 [PF12796], Evalue: 3.3e-16, Aligned region: 380..466 Ank_4 [PF13637], Evalue: 1.9e-15, Aligned region: 378..420 Ank_4 [PF13637], Evalue: 1.9e-15, Aligned region: 428..465 Ank [PF00023], Evalue: 6.9e-14, Aligned region: 378..407 Ank [PF00023], Evalue: 6.9e-14, Aligned region: 410..445 Ank_5 [PF13857], Evalue: 6.7e-12, Aligned region: 375..417 Ank_5 [PF13857], Evalue: 6.7e-12, Aligned region: 406..454 |
| Protein Sequence: 514 a.a. [Download] |
| >gi|52840648|ref|YP_094447.1| ankyrin repeat-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MNSLWIASGSRDMIYVLICIMLVCGLVVYQLMPKLLSYSTSLISKKQDTSELTHDGITNVLTQLGHPKFE GVCYGFTLNWALAVAQGKESFFYRQLHHLRTHQFGLPETLQQIKEKKERNQSLSKDEKIIETLPQLGKKI CIAQDPLQYKEKYKKLVWQPDINSILKAINADSSVAKHIFYKTHSFLNQDEATEYLELLKRTGIREDVAV IISTADHAMGFKLAGNVWRFININDLYQQDKNKPYFEFSSRNLVKELYRVCAENLQGSRLTVNTDFVSVN PEEKLSRALQNLFPVFPVRTKTSYPERLAFFSMAATQGDMNSVKKCIHSGWSIFSRQRLSDDSPILTAIY LGRRDVVRAMLSTSRHRVNQKRKSDSSTLLHIACRYGGSGIVEDLLNIRGIKIDPRDSKGRTPLMYACKK SVVTEDRKLFNLLFAKGASLSIKDNDGLTALDHALKNEHTLAIQMIEERLEKEACAQENSTSRRFKFSET KGTLFQRGVKTISYQSQQPRFGMK |
| - |
| Nucleotide Sequence: 1545 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:443204-444748 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome CTGAATTCATTATGGATAGCATCAGGTTCAAGGGATATGATTTATGTTTTAATTTGTATTATGCTAGTTT GCGGTTTGGTCGTGTATCAACTCATGCCCAAGCTCCTGTCGTATTCTACTTCTTTGATCTCCAAAAAACA GGACACCAGTGAATTAACACATGATGGTATTACGAATGTCTTAACACAATTAGGTCATCCCAAGTTTGAA GGAGTCTGTTATGGCTTCACTCTCAATTGGGCATTGGCGGTGGCTCAGGGTAAGGAATCTTTTTTTTACC GCCAATTGCACCATTTACGAACCCACCAGTTTGGTTTGCCTGAAACATTACAACAAATTAAAGAAAAGAA AGAAAGGAACCAATCATTAAGCAAAGATGAGAAGATCATTGAAACTTTGCCTCAGTTAGGAAAGAAAATT TGTATTGCTCAAGATCCCTTACAATATAAAGAGAAATACAAAAAGCTGGTATGGCAGCCTGATATTAATT CCATTTTGAAAGCCATAAATGCCGACTCTTCGGTTGCAAAGCACATTTTTTATAAGACGCATAGTTTTTT AAATCAGGATGAAGCAACAGAATATCTTGAATTATTAAAAAGAACAGGCATCAGAGAGGATGTTGCAGTA ATTATCAGTACCGCGGATCACGCCATGGGATTTAAACTGGCTGGTAATGTCTGGCGGTTTATTAACATCA ATGACTTATACCAACAAGACAAAAATAAACCTTACTTTGAGTTCTCGTCCCGAAACCTGGTTAAAGAGTT GTATCGTGTTTGTGCCGAAAACCTTCAGGGAAGTCGATTGACCGTGAATACCGATTTTGTTTCAGTTAAT CCTGAAGAAAAACTGTCAAGAGCACTGCAGAATTTATTCCCTGTGTTTCCAGTCAGAACCAAAACTTCTT ATCCTGAACGATTGGCTTTTTTTTCCATGGCAGCAACTCAGGGTGATATGAATTCTGTAAAAAAGTGTAT TCATTCTGGATGGTCAATTTTTTCTCGACAACGACTTAGTGATGATTCACCTATCCTTACAGCCATCTAT TTAGGAAGAAGAGACGTAGTACGTGCCATGCTGAGCACTTCTCGACATAGAGTTAACCAAAAGCGTAAAA GCGACTCTTCTACTTTGCTCCATATTGCCTGTCGGTATGGTGGTAGTGGTATAGTCGAAGATCTGTTGAA CATACGTGGAATTAAAATCGATCCCCGAGACAGCAAGGGGAGAACGCCGCTCATGTACGCCTGTAAAAAA TCTGTAGTGACGGAGGATAGAAAATTATTTAATTTGTTGTTTGCAAAAGGCGCTTCTCTTTCTATTAAAG ATAATGACGGTTTGACCGCACTTGATCATGCTCTTAAAAATGAGCATACCCTTGCAATCCAAATGATCGA GGAGAGATTGGAAAAAGAAGCTTGTGCGCAGGAGAACTCAACCTCTCGTCGATTTAAATTTTCTGAGACA AAAGGTACTTTGTTCCAGAGAGGAGTGAAAACTATTTCTTATCAATCACAGCAACCTCGTTTTGGTATGA AATAG |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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| experimental literature |
| in silico analysis literature |