| Effector Protein ID: 52840635 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | vipA |
| Locus tag | lpg0390 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 431953..433011 [-] |
| Product | VipA |
| Effector type | Protein |
| Descripton | VipA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Vesicle trafficking |
| UniProt ID | Q5ZYI2 |
| KEGG ID | lpn:lpg0390 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 352 a.a. [Download] |
| >gi|52840635|ref|YP_094434.1| VipA [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKHYDSMDQELITMPISNAFLKLFSEFVDNYARNGTPSFYHWAKEQNHEVINKFFHELLEIIKSNTETFH DVSIIEHLNATVLLSAKTNPYLLDCWISFITKYNAETNSFTPIGASMHIKVGPEGTPSERIIRELKESLV MTQQAFILAQKANATEVDSLKRQLEQTKQENERLVTQNQFLKDQVRAEKTFADLNPQINNARQQLSALTE LIQTLSEITNAKPKIETVSSLSIPVVTENKSELLKENSCSVASVSKEVTPAISQEPKKRPVPPPPNDTDG QALSPNIPPKEDVSIKVTIPSMPKPNSTQPAAKNSGFFSGDGFLKELNAKIKERKERPKDEPHTTPVEKK NL |
| - |
| Nucleotide Sequence: 1059 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c433011-431953 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAAACACTATGATTCCATGGATCAGGAGTTAATTACCATGCCTATCAGTAATGCCTTTCTTAAGTTAT TCAGTGAATTTGTTGATAATTATGCGCGCAATGGCACCCCTTCATTTTATCATTGGGCAAAGGAACAAAA CCATGAAGTCATTAACAAATTTTTCCATGAGCTTTTGGAAATTATTAAATCAAACACAGAAACATTTCAT GATGTCAGTATCATAGAGCACCTTAATGCTACAGTACTATTATCAGCAAAGACCAATCCCTACTTACTCG ATTGTTGGATTTCATTTATTACTAAATACAATGCTGAAACCAACAGTTTTACCCCAATAGGGGCTTCGAT GCACATTAAAGTCGGGCCAGAAGGCACGCCATCCGAACGGATAATAAGGGAGCTCAAAGAAAGTCTGGTC ATGACGCAACAAGCGTTTATTTTAGCTCAAAAGGCCAATGCTACGGAAGTTGATTCTTTAAAAAGACAAC TTGAGCAAACAAAGCAAGAAAACGAGCGCTTAGTCACACAAAATCAGTTTCTAAAGGATCAAGTCAGGGC AGAGAAAACATTTGCAGACCTTAACCCACAGATTAACAATGCCCGGCAGCAACTCAGTGCTTTAACAGAA TTAATACAAACTCTAAGCGAAATCACAAATGCCAAACCCAAAATAGAAACTGTATCTTCCTTATCCATTC CAGTTGTTACAGAAAATAAATCTGAACTTCTAAAGGAAAATTCATGCTCTGTCGCTTCTGTATCCAAGGA AGTTACTCCTGCAATCAGTCAAGAGCCGAAAAAAAGACCAGTTCCACCCCCCCCCAATGATACGGATGGT CAAGCATTATCCCCCAATATACCCCCTAAAGAAGATGTGTCTATAAAAGTTACAATACCGTCCATGCCCA AACCAAATTCAACCCAGCCTGCTGCAAAAAATTCAGGTTTCTTTTCAGGCGATGGTTTTTTAAAAGAGTT AAATGCAAAAATTAAAGAAAGAAAGGAACGCCCAAAAGATGAGCCACATACCACTCCCGTCGAAAAAAAA AATCTCTAG |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Rasis M; Segal G (2009). The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors. Mol Microbiol. 72(4):995-1010. [PudMed:19400807]
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(4) VanRheenen SM; Luo ZQ; O'Connor T; Isberg RR (2006). Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells. Infect Immun. 74(6):3597-606. [PudMed:16714592]
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| experimental literature |
| in silico analysis literature |