| Effector Protein ID: 52840621 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | sdhA |
| Locus tag | lpg0376 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 414780..419069 [-] |
| Product | protein SdhA |
| Effector type | Protein |
| Descripton | SdhA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SdhA is critical for intracellular growth and functions to prevent host cell death. SdhA also functions to inhibit Legionella infection-induced type I interferon response. Besides, SdhA prevente bacterial DNA release and AIM2 inflammasome activation. |
| UniProt ID | Q5ZYJ6 |
| KEGG ID | lpn:lpg0376 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1429 a.a. [Download] |
| >gi|52840621|ref|YP_094420.1| protein SdhA [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MISEKIKLLESFKQNQFSKLIEKINSKILATLKSGHFNPRLAPYLEKMNKDGVPFTNFDLDPENISQIKK LINALYHARLAFLDLENIDIGNIKRTIPDLKLLYSNTIHQAYQAGYLITNLDVDLQEMFKEEIDLILPVI GKLQAFAGEHQECTKRLAESWKDFPISYKAGEVTGIALEQMQPRTGDWDYQFLTQFSAVLPGYIEKLTQY IQQYSSQIKEKEPTLNNEKLEELQNASLKLLNDLEHLKGNDFFISLKVLKYIHIIRNIITLATSSVEQMG HFSDSSQDVIRDNLAQLKYVVLPTLFGLVDKIEDNAMLKPGTLSIPLMEKIKPLYQLLIYYASKPVNFKE KGEELLSIEDSRFLALRLERTYQRIDEANKALFKIQKAQEALDNFYKILDTPPYNKQPIHQLPKEIKNQL ITYYKIISPYMMDVDPDLNILLIDSFQGPESWSSYLKKPWRWLRGTLPADHASFVLAQKEALQTLISKKK ATQQFHIELNRDLIESVHKQTNLVLFPYSEKTNVFLLDETKALNPANGATDKLKFRPEKGHNILVNPEDL TSEQALDLYQWYRNKREKFRVASKAYNEFITLLKKQTKTIAETEGRILHLNNLDKETKTRCRNLYNIFQP YFIDGIPPELRASAISFDKFLVHSFSNESSTYDAPAVDLFEKLDEHFQIYFTEIDLQWGKKSNQYLKWAQ EKFASENNSTELEHDEKLESRAHHLIKHTNFSKCIHEFRTELNQVISFFNNAMRAQLKQQPNGIPYPELQ DHNKELAQSEQVVAIKRIFNSLYHVEKIVVELEKLDTRSYESIYVYHLIQAYDHINEIKKLALKLAVDPH FKLIASELLEKAQTLIATIQEHSDAYQVSPLEVPYNQDIKYNALWYTLNAFYISPKHIRSLRNTNYLTTE ELNDLHLKAKKATVTVENIIKSSNSYFKLFLQTPAMYSLYREMTNKLNEFISTSHDAVMNNLDQFRSKIF TPMLMEADAWEDKLGLVPGTISGPLKTITDEYYKGLLHPLALHSKAHIRMICDKTPIDQRIKTTNKKLEN ATQHLDKIEKNYKHIIKLYEIIKTKGGKTTDDELIETYKKALYKLVKLQKRLPQNTDPDPKDYELDTLLN SELKEYEPKLTLIKPLIISSYHHYEGLKATYLMKANTAREKLTYLKELRSTQEQEDLLYIEEYTTESFNK QLDAFCNRHIGLQYTDKEYRTKLREYLLTFKESIIQRSKSAEDINLTIKNLLKEKIKNFERDNFEKYYHL DAVRVALAQFKNYFSLSTAAIEQNNSTFESEETLAKKTELINKLVDISEDGTLTPKERVDQISFHVKNPN FERIIMDYKQESYFSFTYLKQCILSLLEALCLYTPERRKLFNNLESSVKTQPKINELTKRFGLFAGNESA ISSESRAITPVSSVENNGTIELNQLAPSA |
| - |
| Nucleotide Sequence: 4290 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c419069-414780 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGATTTCAGAAAAGATCAAGCTTTTAGAATCCTTTAAGCAAAACCAATTCTCTAAATTAATTGAAAAAA TTAATTCAAAAATCCTTGCGACTTTAAAAAGTGGACATTTCAACCCCAGACTGGCCCCCTACTTGGAAAA AATGAATAAAGACGGGGTTCCATTCACCAATTTTGATCTTGATCCGGAAAATATTTCTCAAATCAAGAAA CTCATTAACGCCCTTTACCATGCCCGTTTAGCTTTTCTGGATTTAGAGAATATTGACATAGGGAACATCA AACGAACTATCCCCGATCTCAAATTACTTTATAGCAACACGATTCACCAGGCCTATCAAGCCGGTTATCT AATCACTAACCTCGATGTTGATTTGCAGGAAATGTTCAAGGAAGAGATTGATCTTATTCTCCCTGTCATT GGAAAATTACAAGCTTTTGCTGGTGAACACCAGGAATGCACCAAGCGTTTGGCAGAGTCTTGGAAGGATT TTCCTATAAGCTATAAAGCAGGAGAAGTTACAGGCATTGCCTTAGAGCAAATGCAACCGAGAACAGGAGA TTGGGATTACCAATTCCTCACTCAATTCAGTGCCGTATTACCTGGTTATATAGAAAAATTAACTCAATAC ATTCAACAATACTCTTCGCAAATCAAAGAAAAAGAGCCTACCCTAAATAATGAAAAGCTGGAAGAATTAC AAAACGCATCATTAAAATTACTAAATGACCTGGAACATCTGAAAGGGAATGACTTTTTTATATCCCTTAA AGTTTTAAAATACATTCACATTATCCGTAATATCATCACATTGGCGACAAGCTCTGTTGAACAAATGGGA CATTTCAGCGATTCATCCCAGGATGTCATTCGTGATAATTTGGCTCAATTAAAATACGTTGTATTACCTA CTTTATTTGGATTAGTAGATAAAATTGAAGACAATGCCATGCTGAAGCCTGGCACACTGTCCATTCCGTT AATGGAAAAAATCAAACCTCTATACCAACTTTTAATTTATTACGCATCCAAACCCGTCAATTTCAAAGAA AAAGGAGAAGAGTTACTCAGTATAGAGGACTCCCGTTTTCTCGCTTTAAGACTGGAAAGAACATATCAAC GAATTGATGAAGCTAACAAAGCCCTTTTTAAAATTCAAAAAGCGCAAGAAGCTCTGGATAATTTTTACAA AATATTGGACACCCCCCCCTATAATAAGCAACCCATACATCAATTACCGAAAGAAATTAAAAACCAACTG ATTACATATTACAAAATAATCAGTCCTTATATGATGGATGTGGATCCTGATCTCAATATTTTGTTGATCG ATAGTTTTCAGGGCCCGGAATCCTGGTCTTCTTATTTAAAGAAGCCGTGGCGTTGGTTAAGAGGCACTCT TCCTGCCGATCACGCCAGTTTTGTTTTAGCGCAAAAGGAAGCATTACAAACTTTAATTAGCAAAAAGAAA GCCACTCAACAATTTCATATCGAATTGAATAGAGACCTTATCGAATCTGTTCACAAACAAACAAATCTGG TTTTATTTCCTTATAGTGAAAAAACGAATGTCTTTCTTCTAGATGAGACAAAAGCACTAAACCCTGCTAA TGGCGCTACGGACAAACTAAAATTCAGGCCAGAGAAAGGACATAATATACTGGTTAATCCTGAGGATTTA ACATCTGAACAGGCTCTTGACCTCTATCAATGGTATAGAAACAAACGTGAAAAATTCAGAGTTGCCAGCA AAGCATATAACGAATTTATTACCTTATTAAAAAAGCAAACCAAGACAATCGCTGAAACGGAAGGCAGGAT TCTCCATTTAAATAATCTTGATAAAGAGACCAAAACTCGCTGCCGTAATTTATATAATATATTTCAACCT TATTTTATCGATGGGATACCTCCTGAACTCAGAGCTTCCGCAATAAGTTTTGACAAATTTTTGGTCCATT CCTTTTCTAATGAGTCATCCACCTATGATGCTCCGGCAGTTGACCTGTTTGAAAAACTGGATGAACATTT TCAAATTTATTTTACAGAAATTGATTTACAATGGGGTAAAAAGAGTAATCAATATTTAAAATGGGCCCAG GAAAAATTTGCCAGTGAAAATAACTCAACCGAACTTGAACATGATGAAAAACTGGAAAGCAGAGCCCATC ATTTAATTAAACATACCAATTTCTCTAAATGCATACATGAGTTCAGAACGGAGCTTAATCAAGTCATTTC GTTTTTTAATAATGCGATGAGGGCACAATTAAAACAACAACCCAATGGAATACCTTACCCTGAATTGCAA GATCACAACAAAGAACTTGCCCAGAGTGAACAGGTTGTTGCGATAAAACGCATATTCAATAGCCTCTATC ATGTTGAAAAGATTGTTGTTGAACTGGAAAAACTCGACACCAGAAGTTACGAAAGCATTTATGTCTATCA TTTAATACAAGCATATGATCACATTAATGAAATTAAGAAATTAGCGCTAAAACTCGCTGTTGATCCTCAT TTTAAGCTCATAGCAAGCGAGTTACTGGAAAAAGCGCAAACTCTTATTGCAACAATACAAGAACACAGTG ATGCGTATCAGGTATCCCCCTTAGAAGTACCTTATAACCAGGATATTAAATACAATGCTCTCTGGTATAC ACTCAATGCTTTTTATATTTCGCCAAAACACATTAGAAGTTTAAGAAATACCAACTATCTCACGACAGAA GAACTCAACGACTTACACTTAAAGGCAAAAAAAGCAACCGTTACTGTAGAAAATATCATTAAAAGTTCAA ACTCCTATTTCAAATTATTCTTACAAACGCCTGCCATGTATTCTCTCTATAGAGAAATGACGAACAAACT GAATGAGTTTATTAGCACATCACATGACGCCGTAATGAATAATCTGGATCAATTCCGCTCCAAGATTTTT ACACCCATGCTGATGGAAGCGGACGCATGGGAAGATAAATTAGGATTGGTACCAGGCACTATCTCAGGAC CATTAAAAACAATAACGGATGAATATTATAAAGGCCTGTTACATCCTTTAGCGCTGCATTCCAAAGCACA TATTCGAATGATATGTGATAAAACACCAATAGATCAAAGAATAAAAACAACGAATAAAAAACTCGAAAAT GCAACACAACATTTGGATAAAATAGAAAAAAATTATAAACATATCATCAAGCTATATGAAATTATCAAAA CAAAAGGTGGCAAAACCACTGATGATGAATTAATCGAAACTTATAAAAAAGCTCTGTACAAATTGGTAAA ACTACAAAAGAGATTACCCCAGAATACAGATCCTGATCCTAAAGATTATGAATTAGACACTCTTTTAAAT TCAGAGCTGAAAGAGTATGAACCTAAATTAACGCTCATTAAGCCTCTCATTATCTCAAGCTACCATCATT ATGAAGGCTTAAAAGCCACTTATCTTATGAAAGCAAATACTGCCAGAGAAAAGTTGACTTATCTTAAAGA GTTACGATCGACTCAGGAACAAGAAGATCTCCTTTATATAGAAGAATACACTACAGAATCATTTAATAAA CAATTAGATGCTTTCTGCAACCGTCATATAGGTTTACAATACACTGACAAGGAATATCGCACAAAACTTA GAGAATATTTACTGACTTTCAAAGAAAGTATTATTCAACGCTCAAAATCCGCAGAAGATATTAATTTAAC TATAAAAAATTTGCTAAAGGAAAAAATTAAAAATTTTGAAAGAGATAATTTTGAGAAATATTATCATCTT GATGCAGTAAGAGTCGCTTTAGCTCAATTTAAAAACTACTTTAGTCTTTCTACCGCTGCCATCGAGCAAA ATAATTCGACATTTGAAAGCGAAGAGACACTGGCGAAAAAGACAGAGCTCATTAATAAACTGGTTGATAT CAGTGAAGATGGAACCCTTACGCCAAAAGAGCGTGTAGACCAAATATCATTCCATGTTAAAAATCCTAAT TTTGAAAGAATCATCATGGATTACAAACAGGAAAGCTATTTTAGCTTTACCTATTTAAAACAATGCATCT TATCCTTATTGGAAGCGCTTTGCCTGTACACTCCGGAGAGAAGAAAACTATTTAATAATTTGGAAAGCTC TGTAAAAACCCAGCCTAAAATCAATGAATTGACCAAACGATTTGGATTATTTGCTGGCAATGAGTCAGCT ATCTCTAGTGAATCCAGGGCAATTACCCCAGTTTCTTCTGTTGAAAATAATGGAACAATTGAGTTAAACC AATTAGCGCCATCCGCATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| (2) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602] |
(3) Monroe KM et al. (2009). Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila. PLoS Pathog. 5(11):e1000665. [PudMed:19936053] 
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(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |