SecReT4
Effector Protein ID: 52840621
T4SS name [ID]Dot/Icm [5]
Gene symbolsdhA
Locus taglpg0376
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]414780..419069 [-]
Productprotein SdhA
Effector typeProtein
DescriptonSdhA
T4CP requirementT4CP Depedent
Target/EffectionSdhA is critical for intracellular growth and functions to prevent host cell death. SdhA also functions to inhibit Legionella infection-induced type I interferon response. Besides, SdhA prevente bacterial DNA release and AIM2 inflammasome activation.
UniProt IDQ5ZYJ6
KEGG IDlpn:lpg0376
PDB IDNA
Domain hit(s) vs Pfam NA
Protein Sequence: 1429 a.a.     [Download]
>gi|52840621|ref|YP_094420.1| protein SdhA [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MISEKIKLLESFKQNQFSKLIEKINSKILATLKSGHFNPRLAPYLEKMNKDGVPFTNFDLDPENISQIKK
LINALYHARLAFLDLENIDIGNIKRTIPDLKLLYSNTIHQAYQAGYLITNLDVDLQEMFKEEIDLILPVI
GKLQAFAGEHQECTKRLAESWKDFPISYKAGEVTGIALEQMQPRTGDWDYQFLTQFSAVLPGYIEKLTQY
IQQYSSQIKEKEPTLNNEKLEELQNASLKLLNDLEHLKGNDFFISLKVLKYIHIIRNIITLATSSVEQMG
HFSDSSQDVIRDNLAQLKYVVLPTLFGLVDKIEDNAMLKPGTLSIPLMEKIKPLYQLLIYYASKPVNFKE
KGEELLSIEDSRFLALRLERTYQRIDEANKALFKIQKAQEALDNFYKILDTPPYNKQPIHQLPKEIKNQL
ITYYKIISPYMMDVDPDLNILLIDSFQGPESWSSYLKKPWRWLRGTLPADHASFVLAQKEALQTLISKKK
ATQQFHIELNRDLIESVHKQTNLVLFPYSEKTNVFLLDETKALNPANGATDKLKFRPEKGHNILVNPEDL
TSEQALDLYQWYRNKREKFRVASKAYNEFITLLKKQTKTIAETEGRILHLNNLDKETKTRCRNLYNIFQP
YFIDGIPPELRASAISFDKFLVHSFSNESSTYDAPAVDLFEKLDEHFQIYFTEIDLQWGKKSNQYLKWAQ
EKFASENNSTELEHDEKLESRAHHLIKHTNFSKCIHEFRTELNQVISFFNNAMRAQLKQQPNGIPYPELQ
DHNKELAQSEQVVAIKRIFNSLYHVEKIVVELEKLDTRSYESIYVYHLIQAYDHINEIKKLALKLAVDPH
FKLIASELLEKAQTLIATIQEHSDAYQVSPLEVPYNQDIKYNALWYTLNAFYISPKHIRSLRNTNYLTTE
ELNDLHLKAKKATVTVENIIKSSNSYFKLFLQTPAMYSLYREMTNKLNEFISTSHDAVMNNLDQFRSKIF
TPMLMEADAWEDKLGLVPGTISGPLKTITDEYYKGLLHPLALHSKAHIRMICDKTPIDQRIKTTNKKLEN
ATQHLDKIEKNYKHIIKLYEIIKTKGGKTTDDELIETYKKALYKLVKLQKRLPQNTDPDPKDYELDTLLN
SELKEYEPKLTLIKPLIISSYHHYEGLKATYLMKANTAREKLTYLKELRSTQEQEDLLYIEEYTTESFNK
QLDAFCNRHIGLQYTDKEYRTKLREYLLTFKESIIQRSKSAEDINLTIKNLLKEKIKNFERDNFEKYYHL
DAVRVALAQFKNYFSLSTAAIEQNNSTFESEETLAKKTELINKLVDISEDGTLTPKERVDQISFHVKNPN
FERIIMDYKQESYFSFTYLKQCILSLLEALCLYTPERRKLFNNLESSVKTQPKINELTKRFGLFAGNESA
ISSESRAITPVSSVENNGTIELNQLAPSA
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Nucleotide Sequence: 4290 bp     [Download]
>gi|52840256|ref|NC_002942.5|:c419069-414780 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATGATTTCAGAAAAGATCAAGCTTTTAGAATCCTTTAAGCAAAACCAATTCTCTAAATTAATTGAAAAAA
TTAATTCAAAAATCCTTGCGACTTTAAAAAGTGGACATTTCAACCCCAGACTGGCCCCCTACTTGGAAAA
AATGAATAAAGACGGGGTTCCATTCACCAATTTTGATCTTGATCCGGAAAATATTTCTCAAATCAAGAAA
CTCATTAACGCCCTTTACCATGCCCGTTTAGCTTTTCTGGATTTAGAGAATATTGACATAGGGAACATCA
AACGAACTATCCCCGATCTCAAATTACTTTATAGCAACACGATTCACCAGGCCTATCAAGCCGGTTATCT
AATCACTAACCTCGATGTTGATTTGCAGGAAATGTTCAAGGAAGAGATTGATCTTATTCTCCCTGTCATT
GGAAAATTACAAGCTTTTGCTGGTGAACACCAGGAATGCACCAAGCGTTTGGCAGAGTCTTGGAAGGATT
TTCCTATAAGCTATAAAGCAGGAGAAGTTACAGGCATTGCCTTAGAGCAAATGCAACCGAGAACAGGAGA
TTGGGATTACCAATTCCTCACTCAATTCAGTGCCGTATTACCTGGTTATATAGAAAAATTAACTCAATAC
ATTCAACAATACTCTTCGCAAATCAAAGAAAAAGAGCCTACCCTAAATAATGAAAAGCTGGAAGAATTAC
AAAACGCATCATTAAAATTACTAAATGACCTGGAACATCTGAAAGGGAATGACTTTTTTATATCCCTTAA
AGTTTTAAAATACATTCACATTATCCGTAATATCATCACATTGGCGACAAGCTCTGTTGAACAAATGGGA
CATTTCAGCGATTCATCCCAGGATGTCATTCGTGATAATTTGGCTCAATTAAAATACGTTGTATTACCTA
CTTTATTTGGATTAGTAGATAAAATTGAAGACAATGCCATGCTGAAGCCTGGCACACTGTCCATTCCGTT
AATGGAAAAAATCAAACCTCTATACCAACTTTTAATTTATTACGCATCCAAACCCGTCAATTTCAAAGAA
AAAGGAGAAGAGTTACTCAGTATAGAGGACTCCCGTTTTCTCGCTTTAAGACTGGAAAGAACATATCAAC
GAATTGATGAAGCTAACAAAGCCCTTTTTAAAATTCAAAAAGCGCAAGAAGCTCTGGATAATTTTTACAA
AATATTGGACACCCCCCCCTATAATAAGCAACCCATACATCAATTACCGAAAGAAATTAAAAACCAACTG
ATTACATATTACAAAATAATCAGTCCTTATATGATGGATGTGGATCCTGATCTCAATATTTTGTTGATCG
ATAGTTTTCAGGGCCCGGAATCCTGGTCTTCTTATTTAAAGAAGCCGTGGCGTTGGTTAAGAGGCACTCT
TCCTGCCGATCACGCCAGTTTTGTTTTAGCGCAAAAGGAAGCATTACAAACTTTAATTAGCAAAAAGAAA
GCCACTCAACAATTTCATATCGAATTGAATAGAGACCTTATCGAATCTGTTCACAAACAAACAAATCTGG
TTTTATTTCCTTATAGTGAAAAAACGAATGTCTTTCTTCTAGATGAGACAAAAGCACTAAACCCTGCTAA
TGGCGCTACGGACAAACTAAAATTCAGGCCAGAGAAAGGACATAATATACTGGTTAATCCTGAGGATTTA
ACATCTGAACAGGCTCTTGACCTCTATCAATGGTATAGAAACAAACGTGAAAAATTCAGAGTTGCCAGCA
AAGCATATAACGAATTTATTACCTTATTAAAAAAGCAAACCAAGACAATCGCTGAAACGGAAGGCAGGAT
TCTCCATTTAAATAATCTTGATAAAGAGACCAAAACTCGCTGCCGTAATTTATATAATATATTTCAACCT
TATTTTATCGATGGGATACCTCCTGAACTCAGAGCTTCCGCAATAAGTTTTGACAAATTTTTGGTCCATT
CCTTTTCTAATGAGTCATCCACCTATGATGCTCCGGCAGTTGACCTGTTTGAAAAACTGGATGAACATTT
TCAAATTTATTTTACAGAAATTGATTTACAATGGGGTAAAAAGAGTAATCAATATTTAAAATGGGCCCAG
GAAAAATTTGCCAGTGAAAATAACTCAACCGAACTTGAACATGATGAAAAACTGGAAAGCAGAGCCCATC
ATTTAATTAAACATACCAATTTCTCTAAATGCATACATGAGTTCAGAACGGAGCTTAATCAAGTCATTTC
GTTTTTTAATAATGCGATGAGGGCACAATTAAAACAACAACCCAATGGAATACCTTACCCTGAATTGCAA
GATCACAACAAAGAACTTGCCCAGAGTGAACAGGTTGTTGCGATAAAACGCATATTCAATAGCCTCTATC
ATGTTGAAAAGATTGTTGTTGAACTGGAAAAACTCGACACCAGAAGTTACGAAAGCATTTATGTCTATCA
TTTAATACAAGCATATGATCACATTAATGAAATTAAGAAATTAGCGCTAAAACTCGCTGTTGATCCTCAT
TTTAAGCTCATAGCAAGCGAGTTACTGGAAAAAGCGCAAACTCTTATTGCAACAATACAAGAACACAGTG
ATGCGTATCAGGTATCCCCCTTAGAAGTACCTTATAACCAGGATATTAAATACAATGCTCTCTGGTATAC
ACTCAATGCTTTTTATATTTCGCCAAAACACATTAGAAGTTTAAGAAATACCAACTATCTCACGACAGAA
GAACTCAACGACTTACACTTAAAGGCAAAAAAAGCAACCGTTACTGTAGAAAATATCATTAAAAGTTCAA
ACTCCTATTTCAAATTATTCTTACAAACGCCTGCCATGTATTCTCTCTATAGAGAAATGACGAACAAACT
GAATGAGTTTATTAGCACATCACATGACGCCGTAATGAATAATCTGGATCAATTCCGCTCCAAGATTTTT
ACACCCATGCTGATGGAAGCGGACGCATGGGAAGATAAATTAGGATTGGTACCAGGCACTATCTCAGGAC
CATTAAAAACAATAACGGATGAATATTATAAAGGCCTGTTACATCCTTTAGCGCTGCATTCCAAAGCACA
TATTCGAATGATATGTGATAAAACACCAATAGATCAAAGAATAAAAACAACGAATAAAAAACTCGAAAAT
GCAACACAACATTTGGATAAAATAGAAAAAAATTATAAACATATCATCAAGCTATATGAAATTATCAAAA
CAAAAGGTGGCAAAACCACTGATGATGAATTAATCGAAACTTATAAAAAAGCTCTGTACAAATTGGTAAA
ACTACAAAAGAGATTACCCCAGAATACAGATCCTGATCCTAAAGATTATGAATTAGACACTCTTTTAAAT
TCAGAGCTGAAAGAGTATGAACCTAAATTAACGCTCATTAAGCCTCTCATTATCTCAAGCTACCATCATT
ATGAAGGCTTAAAAGCCACTTATCTTATGAAAGCAAATACTGCCAGAGAAAAGTTGACTTATCTTAAAGA
GTTACGATCGACTCAGGAACAAGAAGATCTCCTTTATATAGAAGAATACACTACAGAATCATTTAATAAA
CAATTAGATGCTTTCTGCAACCGTCATATAGGTTTACAATACACTGACAAGGAATATCGCACAAAACTTA
GAGAATATTTACTGACTTTCAAAGAAAGTATTATTCAACGCTCAAAATCCGCAGAAGATATTAATTTAAC
TATAAAAAATTTGCTAAAGGAAAAAATTAAAAATTTTGAAAGAGATAATTTTGAGAAATATTATCATCTT
GATGCAGTAAGAGTCGCTTTAGCTCAATTTAAAAACTACTTTAGTCTTTCTACCGCTGCCATCGAGCAAA
ATAATTCGACATTTGAAAGCGAAGAGACACTGGCGAAAAAGACAGAGCTCATTAATAAACTGGTTGATAT
CAGTGAAGATGGAACCCTTACGCCAAAAGAGCGTGTAGACCAAATATCATTCCATGTTAAAAATCCTAAT
TTTGAAAGAATCATCATGGATTACAAACAGGAAAGCTATTTTAGCTTTACCTATTTAAAACAATGCATCT
TATCCTTATTGGAAGCGCTTTGCCTGTACACTCCGGAGAGAAGAAAACTATTTAATAATTTGGAAAGCTC
TGTAAAAACCCAGCCTAAAATCAATGAATTGACCAAACGATTTGGATTATTTGCTGGCAATGAGTCAGCT
ATCTCTAGTGAATCCAGGGCAATTACCCCAGTTTCTTCTGTTGAAAATAATGGAACAATTGAGTTAAACC
AATTAGCGCCATCCGCATAA

Reference
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(2) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602]
(3) Monroe KM et al. (2009). Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila. PLoS Pathog. 5(11):e1000665. [PudMed:19936053] experimental
(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature