| Effector Protein ID: 52840531 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legG2 |
| Locus tag | lpg0276 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 327062..328561 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LegG2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegG2, which has a Ras GEF domain, is believed to be involved in GDP-to-GTP exchange in Ras GTP-binding protein (de Felipe, et al. 2005) |
| UniProt ID | Q5ZYT5 |
| KEGG ID | lpn:lpg0276 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | RasGEF [PF00617], Evalue: 1.8e-10, Aligned region: 77..237 |
| Protein Sequence: 499 a.a. [Download] |
| >gi|52840531|ref|YP_094330.1| hypothetical protein lpg0276 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MINKSRLLSLIACFNNREINMPKILDSHAYREMENELNTLFEQIYKHGKNDRTAITLQAQQFLDNLSESI RDHSRLLLTKIAREELIYFKEKKPGDSREKFQNIDKMSDYFNNLSALINFSVMQQEDPTLRAFYYDMYIQ LMNFCYLKGDLFGAGAIYTGLIANNLPNSIDWKQLSSESRLIFKDCEEKFKRLFNLSTTYNAHTDLKRQF KTALIPALPSLLTVQIYTKDSYDNSVSDFERIQDKLRQLDIEHNRFLNQLQNDRSTWSKAYYDYMSNVYL PQSIFEYTTLLREYEELVTTHGGPIAKQFHKDKNSEPLVNFVESTLSENQSVLKVSPFQNERIVEMLSEI DVVKSECSSPAVFDDLSWKLREMNCTLVKAKSIGDYTSKIFANLDTPYMEENTDEDPKPVLVEELQTDDV YQLHHSGMKLMRELEQAIEDHKPKVIYHCSGEANYGFFKEARRRGRHLSREPMDIEVMDMDVMDYDENDL RDQTVMITV |
| - |
| Nucleotide Sequence: 1500 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:327062-328561 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome TTGATAAATAAAAGTCGTTTGTTGTCATTAATTGCATGTTTTAATAATAGAGAAATCAATATGCCTAAAA TTTTAGATAGCCATGCATATCGCGAGATGGAAAATGAGCTCAATACTCTTTTCGAGCAAATTTATAAGCA TGGTAAAAATGACAGAACCGCGATTACATTACAAGCTCAGCAATTTTTAGATAATTTGAGTGAATCCATA AGGGATCATTCCCGCTTATTGCTTACCAAAATTGCCAGAGAAGAACTCATTTATTTTAAGGAAAAGAAAC CTGGGGATTCGCGAGAGAAATTTCAAAATATCGATAAGATGAGTGATTACTTTAACAATTTATCTGCATT GATTAATTTCTCGGTGATGCAGCAAGAAGATCCTACTCTGCGGGCTTTTTATTATGATATGTATATTCAA CTAATGAATTTTTGCTATCTTAAAGGGGATTTGTTTGGAGCGGGTGCAATTTATACAGGTTTAATAGCCA ATAACCTCCCTAACTCTATTGATTGGAAGCAATTGAGTTCCGAGAGTCGCTTGATTTTTAAAGATTGTGA AGAAAAATTTAAGCGATTATTTAATCTCTCAACGACATACAATGCGCACACTGATTTAAAAAGACAATTC AAAACTGCTTTGATACCCGCATTACCGTCACTTCTCACGGTTCAGATATATACTAAGGACTCTTACGATA ACTCGGTCAGCGATTTTGAAAGAATTCAGGATAAGTTACGTCAGTTGGATATAGAACATAATCGGTTTCT TAATCAATTACAAAATGACCGTTCAACCTGGTCTAAAGCTTATTATGATTATATGAGTAATGTTTATCTC CCGCAAAGCATATTCGAATACACTACTCTCTTAAGAGAGTATGAAGAACTTGTTACAACGCATGGTGGCC CTATTGCGAAGCAGTTTCATAAGGATAAGAATTCAGAACCTCTGGTAAATTTTGTTGAATCGACGCTATC AGAAAATCAATCAGTTCTCAAAGTATCTCCTTTTCAAAATGAAAGAATTGTTGAAATGCTTTCCGAGATT GACGTGGTAAAAAGTGAGTGCTCAAGCCCAGCTGTGTTTGATGACCTCTCCTGGAAGTTGAGAGAAATGA ATTGTACTTTGGTAAAAGCCAAATCTATTGGTGATTATACTTCCAAAATTTTTGCAAATCTTGATACTCC ATACATGGAAGAGAATACGGATGAAGACCCGAAACCAGTGCTTGTAGAAGAGCTGCAAACGGATGATGTG TACCAACTTCACCATAGTGGTATGAAATTGATGCGTGAGCTCGAACAGGCTATAGAAGATCATAAACCAA AGGTTATTTATCATTGTTCAGGTGAGGCAAACTATGGTTTCTTTAAGGAAGCCAGAAGGAGGGGGAGACA TTTGAGTCGAGAACCAATGGATATCGAAGTCATGGATATGGATGTGATGGATTATGATGAGAATGATTTA CGTGACCAAACCGTTATGATTACCGTGTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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| experimental literature |
| in silico analysis literature |