| Effector Protein ID: 52840530 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg0275 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 323554..326904 [+] |
| Product | protein SdbA |
| Effector type | Protein |
| Descripton | SdbA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SdbA has been proved to contribute to sustained NF-kappaB activation in A549 epithelial cells, and are essential for L. pneumophila replication (Bartfeld, et al, 2009) |
| UniProt ID | Q5ZYT6 |
| KEGG ID | lpn:lpg0275 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1116 a.a. [Download] |
| >gi|52840530|ref|YP_094329.1| protein SdbA [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MHKKYNYYSLEKEKKTFWQHILDILKAPFRLPGWVVSFFLARNITHVALNPNNIPQQRLIHLTKTSNRPE DDIVVINFKKRPPHKWFNDTLIKIANTIAALPFVTPRLRTRLHYDNENDINHVNKLLAEIDALVQGKSKQ KYCKGRAFDWSKIHLKGLEFLDPKMRGYVYEQLHEKYGYVSYTTKRKPNIEFFTLKTPDGSELDSVQVTG EDEEKKPMGERKFIITCIARDQNFINWIKDLNYTAKNLGATAISFNYRGVDYSRGLVWTENNLVDDILAQ VQRLISLGADPKNICLDGMCIGGAVATIAAAKLHEKGMKVKLNNERSFTSLSSLVFGFIVPELQTANWWS PLTYGRFLLAGVVYALLTPLIWLAGWPVDVTKAWNRIPAQDKMYSVVRDKDNGLYDGVIHDHFCSIASLV DSQINSILYKLSTDQPLTEEEKQILCDDQFSHHFKPSQSVLKNPKYKGPHFISRQDLVAELGHREEYTNH DYFLDRLREKFQLDRATRPVALAEDGEKDIDGISSQLSNNKERPLIIASSGGTGHISATHGIINDLQSKT DNVVITQHHAELYKNKPFSITSVLIRIGVWFTSLPILEDILKGVMRFIGYPVLPSSSIFWDQMSKIQQSE TKKENGIETGRTRPYVDMLLDIYPEGYEYTAFNNATHLTSSIEDIQTMISFKGHVEEDNRNIVYQNILQR LMHAAKQNTPYTRLISTQALSLGAICDAVKYYNTVFLPVYNAERGTSYQPIAIDQYMTDLPSLGCIHFMN NLEELTSEQRQLMEIHAVNMSEPFKEAHFGKEQGFKAVHNIDPRNNPMIRNAFKDPSLTKYLDKTQSFDL HFNVYKKEKQNALPVLNGKEKITIKPHAKIASIMIGSLAANASADYAKYLLNQGYEHIFLFGGLNDSIAA RIDQIINSYPAPTRDEIRKKIILLGNQSDVEMAPIMTRSNCVVIRGGGLSVMEQMAMPIMDDKIVLLHHE DNEEGPLTSGLSWEDGNSDKLIEYLSEKGAYAKKTSPGLCSGHLHEAEKSFEKKYHGQLKSTETKKKVDL TIPQQETYSLKKEWDRKTGYTESGHILSHQHRFFNTIPEVREPFCSKEDLHHNELSSQSLVSVSAG |
| - |
| Nucleotide Sequence: 3351 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:323554-326904 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGCATAAAAAATACAACTACTACAGTCTTGAAAAAGAAAAAAAAACATTCTGGCAACATATACTGGATA TTCTGAAGGCCCCATTTAGGCTACCTGGTTGGGTCGTTTCTTTTTTCTTGGCACGAAATATTACTCATGT GGCATTAAATCCTAATAATATTCCGCAACAACGTTTAATACATCTTACTAAAACAAGCAATCGTCCAGAG GATGATATTGTTGTCATTAATTTCAAAAAACGGCCTCCTCACAAATGGTTTAATGACACGCTGATTAAAA TAGCCAATACCATTGCGGCTCTTCCTTTTGTAACACCAAGATTACGTACAAGATTACATTACGATAATGA GAATGATATCAATCATGTGAACAAGTTGCTTGCCGAGATCGATGCGCTTGTTCAGGGCAAATCAAAACAA AAGTATTGCAAAGGCAGGGCATTCGATTGGTCAAAAATTCATCTAAAGGGATTGGAGTTCCTGGACCCTA AAATGAGAGGGTATGTTTATGAACAACTGCATGAAAAATATGGTTATGTCTCATATACAACAAAACGCAA ACCTAATATTGAATTTTTCACCTTAAAAACTCCTGATGGATCTGAATTGGATTCAGTGCAAGTTACAGGT GAAGACGAAGAAAAAAAACCAATGGGGGAGCGCAAGTTTATTATTACCTGTATTGCGCGGGATCAAAATT TCATCAATTGGATAAAGGATTTAAACTATACGGCAAAAAATCTGGGCGCTACGGCCATCAGCTTCAACTA CAGAGGCGTGGATTACAGTCGCGGTCTTGTCTGGACAGAAAATAATCTTGTCGACGATATTCTGGCTCAG GTGCAAAGGCTAATTAGCCTTGGTGCCGACCCTAAGAACATCTGCCTTGATGGTATGTGTATAGGTGGGG CGGTAGCAACAATTGCTGCAGCAAAACTTCATGAGAAGGGCATGAAAGTCAAGTTGAATAATGAACGCTC TTTTACTTCTCTTTCTTCTCTAGTATTTGGTTTTATTGTACCTGAATTGCAAACAGCAAATTGGTGGAGC CCTTTGACTTATGGTCGCTTCCTACTGGCCGGTGTAGTTTATGCTTTACTCACGCCTTTAATTTGGCTGG CAGGATGGCCAGTTGATGTGACCAAAGCCTGGAATAGAATACCTGCTCAGGATAAAATGTATTCTGTTGT GCGGGATAAAGACAATGGCTTGTACGATGGAGTAATTCACGATCACTTCTGTTCCATTGCGTCGTTGGTT GATTCTCAAATTAATTCTATTTTATATAAATTATCCACTGATCAGCCGCTTACTGAGGAAGAAAAACAAA TTTTGTGTGATGATCAGTTTTCTCACCATTTTAAACCAAGTCAAAGTGTTTTAAAAAATCCAAAATACAA AGGCCCGCATTTTATTTCCCGACAAGATTTGGTAGCTGAGCTTGGTCATCGAGAGGAATATACCAATCAT GATTATTTCCTTGACCGCTTGCGGGAAAAATTTCAATTGGATCGCGCAACACGGCCAGTGGCTTTGGCTG AAGATGGGGAAAAGGATATAGATGGGATTTCATCGCAACTATCTAATAATAAAGAGCGTCCCTTAATTAT TGCCAGCAGTGGAGGAACAGGGCATATCTCTGCCACGCATGGCATCATTAATGATTTACAGAGTAAAACA GATAATGTTGTCATTACGCAGCATCATGCGGAACTCTACAAAAACAAGCCCTTCTCAATTACATCTGTTC TGATTCGTATTGGTGTTTGGTTTACCTCTCTTCCTATCCTGGAAGACATACTGAAAGGAGTTATGAGGTT TATCGGATATCCCGTTTTACCGAGCTCCTCCATCTTTTGGGATCAAATGTCTAAAATACAGCAGAGTGAA ACTAAAAAAGAAAATGGAATTGAAACCGGCAGAACCCGTCCTTATGTGGACATGCTGTTGGATATATACC CGGAGGGATATGAATACACGGCATTCAATAACGCGACTCACTTGACTTCCAGTATTGAAGACATTCAAAC GATGATAAGCTTCAAGGGGCATGTTGAAGAGGATAACAGGAATATAGTCTATCAAAATATATTACAACGC CTTATGCATGCGGCGAAACAGAATACTCCTTACACAAGATTAATTTCCACACAGGCGCTTTCTTTGGGAG CTATTTGCGATGCCGTTAAATACTACAATACGGTATTTTTGCCTGTATACAATGCTGAAAGAGGGACTTC CTATCAGCCTATTGCCATTGATCAGTATATGACCGATTTGCCTTCACTGGGTTGTATTCATTTTATGAAT AATTTGGAGGAGCTCACATCAGAGCAAAGGCAATTGATGGAGATACATGCAGTAAATATGAGTGAACCAT TTAAAGAGGCGCATTTTGGCAAAGAACAAGGCTTTAAAGCGGTTCATAATATTGACCCACGCAATAACCC TATGATTCGCAATGCCTTTAAAGACCCTTCATTGACAAAATACCTGGATAAGACCCAGTCATTTGATTTG CACTTTAATGTTTATAAAAAGGAAAAGCAAAATGCACTGCCAGTACTGAATGGTAAAGAAAAAATTACAA TCAAACCGCATGCTAAAATTGCTTCCATCATGATAGGCTCTCTGGCGGCAAATGCTTCAGCTGATTATGC GAAGTATTTATTGAATCAGGGGTATGAGCATATTTTTCTTTTCGGCGGGCTTAATGATTCCATTGCCGCA CGTATCGATCAAATCATCAATTCTTACCCTGCCCCCACGCGTGATGAGATACGTAAGAAAATTATTCTCC TGGGGAATCAATCTGATGTTGAAATGGCACCAATAATGACCAGAAGTAACTGTGTGGTTATCCGTGGAGG TGGTTTAAGTGTCATGGAACAAATGGCCATGCCCATTATGGATGATAAAATTGTATTATTACATCATGAA GATAATGAAGAGGGCCCTTTAACATCTGGTCTCAGTTGGGAAGATGGGAATTCCGATAAATTAATCGAGT ATCTGTCTGAAAAAGGGGCTTACGCTAAAAAAACATCGCCTGGTCTGTGTTCTGGTCATCTTCATGAGGC AGAAAAGAGTTTCGAAAAGAAATATCATGGGCAACTGAAGTCGACAGAAACCAAGAAAAAAGTAGATTTA ACCATTCCTCAACAAGAGACGTATTCTCTGAAAAAAGAGTGGGATAGAAAAACTGGATATACTGAATCTG GACATATACTATCCCATCAGCATAGATTTTTTAACACGATACCTGAAGTAAGAGAGCCATTCTGTTCTAA GGAAGATTTACATCATAATGAGCTTTCCAGTCAAAGTTTGGTTAGTGTCAGTGCTGGTTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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| experimental literature |
| in silico analysis literature |