| Effector Protein ID: 52840426 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legU1 |
| Locus tag | lpg0171 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 200453..201019 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LegU1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegU1 and Lpg2160 may function redundantly or in concert to modulate BAT3 activity during the course of infection. (Ensminger and Isberg, 2010) |
| UniProt ID | Q5ZZ40 |
| KEGG ID | lpn:lpg0171 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | F-box [PF00646], Evalue: 6.5e-07, Aligned region: 12..54 F-box-like [PF12937], Evalue: 3.7e-05, Aligned region: 13..49 |
| Protein Sequence: 188 a.a. [Download] |
| >gi|52840426|ref|YP_094225.1| hypothetical protein lpg0171 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKAKYDPTKPGLQKLPPEIKVMILEFLDAKSKLALSQTNYGWRDLILDRPEYTKEITNTLFRLDKKRHRQ AIAQMMSGRVTASSMAKLFEELLCFSIPSSYVFLIFFASQKSVALIEVLTVILVFAAITSLAHDLVDYFI ESDTKAEKQHAHRRAFQFFAQPSQSAAQQNLEEENLSADPKACQCEPL |
| - |
| Nucleotide Sequence: 567 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c201019-200453 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAAAGCAAAATACGACCCCACAAAGCCTGGACTCCAAAAGTTACCTCCTGAAATCAAGGTAATGATTC TTGAGTTTCTTGATGCCAAATCAAAACTAGCTCTTTCACAGACAAATTATGGTTGGCGTGATTTAATTCT AGACCGGCCAGAATATACCAAAGAAATAACGAATACATTATTTCGTCTTGATAAAAAACGCCATCGTCAA GCAATAGCACAAATGATGTCAGGAAGAGTTACAGCAAGTTCTATGGCTAAGCTATTTGAAGAATTACTAT GTTTTAGCATACCTTCGTCCTATGTGTTTTTAATCTTTTTCGCATCGCAAAAATCTGTGGCGCTTATAGA AGTCTTAACCGTAATCCTTGTGTTTGCTGCAATAACCTCTCTCGCCCATGATCTGGTGGATTATTTTATT GAAAGTGATACAAAAGCTGAGAAACAGCATGCACATCGCCGTGCTTTTCAATTCTTTGCCCAACCCAGTC AAAGCGCTGCACAACAAAACTTGGAGGAAGAGAATTTAAGTGCTGATCCCAAGGCCTGCCAATGTGAGCC ATTGTAG |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Ensminger AW et al. (2010). E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates. Infect Immun. 78(9):3905-19. [PudMed:20547746] 
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(4) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |