| Effector Protein ID: 52840415 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg0160 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 192160..193137 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | RavD |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZZ51 |
| KEGG ID | lpn:lpg0160 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 325 a.a. [Download] |
| >gi|52840415|ref|YP_094214.1| hypothetical protein lpg0160 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MNLKKEVFLNQNCAEMMIKKAARLILGSDLDFEYTRDVQDIQIDLGPAFMFSPDEEKTLWVSGKNQETLE RDLATLNKSSAYFFRTGTQGGAGHWQVLYYEAAKSGWVSYSSQSNHFQVTDSNGKLTASGKGLLVPHANW GKENGNYAFLLVNASAQNIIHAANFVYIFRTQNEDAAIQYCALNQALHPEIKRITITKVQTQTRLTPEIH CPRGDLSYANLKNVYSKHLALLHVINRLEAGSKSYNPYWMGSQEKLNKIFEALGHCYQKGLDVDNELNNS NSKLSKAINMRRLPSLFSFWCEKNESFVESRKIIEEHRICRLNNL |
| - |
| Nucleotide Sequence: 978 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:192160-193137 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAACTTAAAAAAAGAAGTGTTCTTAAACCAAAATTGTGCAGAAATGATGATAAAGAAAGCTGCTCGGT TGATTTTAGGCAGTGATCTTGATTTTGAATACACTCGAGATGTTCAAGATATTCAAATTGATCTGGGCCC TGCTTTTATGTTCAGTCCAGACGAAGAAAAAACACTGTGGGTTAGTGGGAAAAATCAGGAAACGTTGGAA AGGGATCTGGCGACTCTTAATAAAAGCAGTGCCTACTTTTTCCGGACTGGTACTCAAGGAGGGGCTGGTC ATTGGCAAGTCCTGTACTATGAGGCTGCTAAATCAGGTTGGGTTAGCTATTCATCTCAATCCAATCACTT TCAAGTGACTGACAGCAATGGGAAGTTAACAGCCAGTGGTAAGGGACTGCTTGTTCCCCATGCCAATTGG GGAAAGGAAAATGGAAATTATGCATTTTTGCTCGTAAACGCAAGTGCACAAAACATCATTCATGCAGCGA ATTTCGTGTATATTTTCAGAACTCAGAATGAGGATGCTGCAATACAATATTGTGCGCTCAATCAGGCGCT TCATCCAGAAATAAAGAGAATAACTATAACCAAAGTTCAAACACAAACGAGGTTAACACCAGAGATTCAT TGTCCCCGGGGAGATTTATCTTATGCGAATCTTAAAAATGTATACAGTAAGCATCTAGCCTTGTTGCATG TTATCAACCGCCTGGAAGCAGGAAGTAAAAGCTACAATCCTTACTGGATGGGTAGTCAAGAGAAGCTCAA TAAAATTTTTGAGGCACTTGGACATTGTTATCAAAAAGGCCTTGATGTCGATAATGAATTAAACAATAGC AACAGCAAATTATCCAAAGCAATCAATATGCGCCGCCTCCCATCGCTTTTTAGTTTTTGGTGTGAAAAAA ACGAATCTTTCGTGGAATCAAGAAAAATAATTGAAGAACACAGGATTTGCAGGCTAAATAATTTATAA |
| Reference |
(1) Wan M et al. (2019). A bacterial effector deubiquitinase specifically hydrolyses linear ubiquitin chains to inhibit host inflammatory signalling. Nat Microbiol. 10.1038. [PudMed:31110362] 
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(2) Pike CM et al. (2019). The Legionella effector RavD binds phosphatidylinositol-3-phosphate and helps suppress endolysosomal maturation of the Legionella-containing vacuole. J Biol Chem. 294(16):6405-6415. [PudMed:30733336]
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(3) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |