| Effector Protein ID: 52840358 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | vipF |
| Locus tag | lpg0103 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 118383..119243 [-] |
| Product | GNAT family acetyltransferase |
| Effector type | Protein |
| Descripton | VipF |
| T4CP requirement | T4CP Depedent |
| Target/Effection | VipF has been found to inhibit lysosomal protein trafficking in yeast (Shohdy, et al. 2005) |
| UniProt ID | Q5ZZA8 |
| KEGG ID | lpn:lpg0103 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Acetyltransf_1 [PF00583], Evalue: 2.9e-24, Aligned region: 51..109 Acetyltransf_1 [PF00583], Evalue: 2.9e-24, Aligned region: 191..269 Acetyltransf_7 [PF13508], Evalue: 5.1e-17, Aligned region: 48..102 Acetyltransf_7 [PF13508], Evalue: 5.1e-17, Aligned region: 191..269 Acetyltransf_10 [PF13673], Evalue: 6.6e-15, Aligned region: 48..123 Acetyltransf_10 [PF13673], Evalue: 6.6e-15, Aligned region: 175..268 FR47 [PF08445], Evalue: 1.1e-09, Aligned region: 211..273 Acetyltransf_3 [PF13302], Evalue: 1.5e-09, Aligned region: 172..268 Acetyltransf_8 [PF13523], Evalue: 7.6e-08, Aligned region: 172..272 |
| Protein Sequence: 286 a.a. [Download] |
| >gi|52840358|ref|YP_094157.1| GNAT family acetyltransferase [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MITQVNQLDELQLKDLKTLRAECKKNDGSIPNLYIHILKQHRSLPTSFLYYQNGALIGFLSIYFFYDDAV EVAVLVSPQYRRQGIAKQLIKEALPLIKSQNYFNLIFSCPSRLNDNWLTSKGFTYLHSEYFMERDDLNPI LDYIRPLSFRMATLEDIPILCGLDEVCFPDKNQDSVHRFQQILNEREYEIVIAMLNNHPIGKSHIRWQTK RATLSDIAILPKEQGKGFGSALIAHCINMILSEGKSRVDLDVETHNKKALNLYIQLGFHIQNACDYWSIN VNQLAK |
| - |
| Nucleotide Sequence: 861 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c119243-118383 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGATTACTCAAGTTAACCAATTAGATGAACTTCAATTAAAAGACTTAAAAACATTAAGAGCAGAGTGTA AAAAAAATGATGGCAGCATCCCCAATCTATATATCCATATATTGAAACAACACCGCTCTCTTCCTACAAG CTTCCTTTATTATCAAAACGGGGCCTTGATTGGATTCTTGAGTATTTATTTCTTTTATGATGATGCTGTT GAAGTTGCTGTTCTGGTTAGTCCCCAATATCGCAGACAAGGGATTGCCAAACAATTAATAAAGGAAGCAT TACCCTTAATTAAGTCTCAAAACTACTTTAACTTGATTTTTTCATGCCCCTCACGCCTCAATGATAACTG GTTAACCTCAAAAGGATTTACCTACCTGCATAGCGAATATTTCATGGAACGTGATGATTTAAATCCTATA CTCGATTACATACGTCCATTGTCCTTTCGCATGGCGACTTTAGAGGATATTCCCATATTATGTGGCCTCG ATGAAGTATGTTTTCCTGATAAAAACCAAGACTCGGTTCACCGATTCCAACAAATTCTTAACGAAAGAGA ATATGAAATTGTAATAGCCATGCTCAATAATCATCCCATAGGAAAATCCCATATTCGCTGGCAAACCAAA AGGGCTACCTTGTCTGATATTGCCATATTGCCTAAAGAACAAGGAAAAGGATTTGGTTCTGCCTTGATTG CTCATTGCATCAATATGATTTTGAGCGAAGGCAAATCCCGGGTGGACCTTGACGTTGAAACCCATAATAA AAAAGCATTAAATCTGTATATTCAGCTTGGATTTCATATTCAAAATGCTTGTGATTACTGGTCAATTAAT GTGAATCAACTTGCAAAATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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| experimental literature |
| in silico analysis literature |