| Effector Protein ID: 52840294 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legA10 |
| Locus tag | lpg0038 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 44731..46254 [-] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | AnkQ/legA10 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZZH2 |
| KEGG ID | lpn:lpg0038 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 3e-10, Aligned region: 296..392 Ank_5 [PF13857], Evalue: 6.5e-07, Aligned region: 317..370 Ank_4 [PF13637], Evalue: 5.1e-05, Aligned region: 327..370 |
| Protein Sequence: 507 a.a. [Download] |
| >gi|52840294|ref|YP_094093.1| ankyrin repeat-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MLMAATIPHIETITFTDWFLAIIDTPDIPIDEIEIRVAEGFKRKLTERQFQQLTELIHLISFIKHKKISN PTLALRIYVDENTSSLSRTALVEAVRMLPPEDNKTYELAAYLAQKNKLERYTNITKVPPLQIYQGDGVFE QYDEWILLFELFGLTQATPSDFIPAIAHLLITKNLGIPDLRALSKFMSTTHKLGILSQSFMNNMTPHLCN GQIIEKYESLLLKLQINDLLTEEILEVIYPLLNQPDALDAFFSLYHEEPSHDSALSFLREILPSFCAMSL PSKESYDDQVPTNTPLHLAVIESDKGNLERTLAFANRNLLIKCSYENTALLLACKLADKESARLILAKMQ ELGCDVNQRDHHGMTALHWANFYHFDELIRELEIAGADPQLKAANGKTCEYFYQHQFTLKDLKLNGKEII DGEFKLSDCALTDIAFHMDKIALNLKLTTPSEIAELYARDEIAQIRSSNRFYLFFKLFRPKLINWLEKQN DLEPQVTYRFSGQSSSA |
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| Nucleotide Sequence: 1524 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c46254-44731 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGCTTATGGCCGCAACAATTCCCCATATTGAAACAATTACTTTTACCGACTGGTTCCTGGCAATCATTG ACACTCCAGACATTCCCATCGATGAAATTGAAATCAGAGTAGCTGAAGGCTTTAAGAGAAAATTGACAGA ACGGCAATTTCAACAATTAACGGAATTAATCCATTTAATTAGTTTCATTAAGCACAAGAAAATCTCCAAT CCTACCTTGGCTCTCCGCATCTATGTTGATGAAAATACGAGCTCTCTATCAAGAACTGCTTTGGTTGAAG CAGTCAGGATGCTTCCACCTGAAGATAATAAAACCTATGAGTTAGCAGCCTATTTGGCTCAAAAAAACAA ACTGGAACGATATACTAACATAACGAAAGTGCCTCCTCTGCAAATTTACCAGGGGGATGGCGTATTTGAG CAATACGATGAATGGATTCTTCTTTTTGAACTGTTTGGGTTAACCCAGGCAACGCCCAGCGATTTCATTC CTGCCATTGCTCATTTATTAATCACCAAGAATCTTGGTATTCCTGATCTTAGGGCACTTTCAAAATTTAT GAGCACTACGCATAAACTAGGCATATTAAGCCAAAGTTTTATGAATAATATGACTCCCCATTTATGTAAT GGGCAAATCATAGAAAAGTATGAGTCATTATTGCTTAAATTACAAATTAACGATTTGTTAACTGAGGAAA TTCTGGAAGTGATCTATCCACTCCTCAATCAACCAGATGCTCTTGACGCTTTTTTTTCACTCTATCATGA AGAACCATCGCACGACAGCGCTCTGTCTTTCTTGAGAGAAATTTTGCCATCCTTTTGCGCAATGAGCCTC CCCAGTAAAGAAAGCTATGACGATCAGGTACCAACAAACACGCCTTTGCATCTGGCCGTTATTGAGAGTG ATAAAGGGAATCTGGAACGGACATTAGCCTTTGCCAATCGCAATTTACTAATAAAATGCTCTTATGAAAA TACAGCACTTTTATTAGCTTGTAAACTTGCTGATAAAGAGTCAGCCCGATTGATTTTAGCGAAAATGCAG GAATTAGGCTGTGATGTCAATCAAAGAGATCATCATGGCATGACCGCGCTGCACTGGGCTAATTTTTATC ATTTTGATGAGCTAATCAGGGAGCTAGAGATTGCTGGGGCGGATCCCCAATTAAAAGCAGCCAATGGAAA AACTTGTGAATATTTCTATCAACATCAATTCACTTTGAAAGATTTAAAATTAAATGGCAAAGAAATCATT GATGGTGAATTCAAGTTAAGTGATTGTGCGCTGACGGATATTGCTTTCCATATGGATAAAATAGCCTTAA ATTTAAAATTAACAACACCATCCGAGATTGCAGAACTGTACGCAAGGGATGAAATAGCACAAATTCGTTC AAGCAACCGGTTCTATTTGTTTTTTAAATTATTCCGGCCAAAATTAATCAATTGGTTAGAGAAGCAAAAT GACCTGGAGCCTCAAGTGACTTATCGTTTCTCAGGGCAAAGTTCTTCTGCTTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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(3) Altman E; Segal G (2008). The response regulator CpxR directly regulates expression of several Legionella pneumophila icm/dot components as well as new translocated substrates. J Bacteriol. 190(6):1985-96. [PudMed:18192394]
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| experimental literature |
| in silico analysis literature |