| Effector Protein ID: 52840268 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | - |
| Locus tag | lpg0012 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 15332..16909 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | CegC1/PlcC |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZZJ8 |
| KEGG ID | lpn:lpg0012 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 525 a.a. [Download] |
| >gi|52840268|ref|YP_094067.1| hypothetical protein lpg0012 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MNTTEHTELGNGLLMDKIEGNPYLRIDEFGVLHLRLQRFGENNLPEPMELEMSAGEIIAMAGDYFTQANW TMDLDLPKCELFNSPAELGKHLIRKPIDPKEENALITAYNNLAAPDVTRKEIDRIYSINNANYVPFSPTL NFYAQQLMYYFRVKDYGEMLVRNQTHFTPWSIRVYILGHAIALRYARLSYELKQLATDRNYQSDNPDLST LKISLQNKNETLSSNTLLDLANRYHAQAYSIELFTFHYYSDHFATGHMSMIGDLRVVLKERFGVWGNILA NNLHDEVNRVGVYTVRPYDPTPNTTEAPSRARGDGKFDTCLNQFNRLACLNGMTASLKDINQVLSGGVIP EQKKFGGLVHMPDVDFNSRQHQPLLVLSKGKVYYRNNLSQIHIISPSEYEALRENPEKHGYKELTSKWAA FKLVTKLRLFPYLYDGSVMPVSDEKLAEIIADEKRRNPQRAPIPTPSCLPESEPTVFDWRTKASWRNNKD SLDILDGLKKHSILAAKQTHSAIQEEEEVRLNLGV |
| - |
| Nucleotide Sequence: 1578 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c16909-15332 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAACACAACGGAACATACAGAGCTGGGCAATGGTTTGCTCATGGATAAAATCGAAGGCAATCCATATT TACGAATAGATGAGTTTGGCGTGCTCCATCTGCGACTTCAACGATTCGGTGAAAACAACCTGCCTGAGCC AATGGAGCTGGAGATGTCCGCTGGCGAAATTATTGCCATGGCGGGTGACTACTTTACACAGGCTAATTGG ACTATGGATTTGGATCTGCCCAAATGCGAGCTATTCAACTCCCCGGCAGAATTGGGAAAACACCTCATTC GCAAACCTATAGATCCTAAAGAAGAGAATGCTTTAATTACAGCATACAATAACCTGGCTGCTCCTGATGT TACTCGAAAAGAAATTGATCGCATTTATTCCATTAATAATGCTAACTATGTGCCCTTTTCGCCTACGTTG AATTTCTATGCTCAACAACTGATGTATTATTTTCGCGTCAAAGACTATGGGGAAATGCTTGTTCGGAACC AAACTCATTTTACGCCATGGTCTATTCGAGTTTATATATTGGGTCACGCTATCGCATTGAGATATGCACG TTTATCCTACGAATTAAAACAATTGGCTACCGACAGAAACTATCAATCAGATAACCCTGACTTGAGTACT TTAAAAATCTCATTACAAAATAAGAATGAAACTCTTTCAAGCAATACCCTGCTTGATTTGGCGAATCGCT ATCACGCCCAAGCTTATTCTATAGAGCTGTTTACTTTTCACTACTATTCTGATCATTTTGCTACAGGACA TATGTCCATGATTGGCGATTTACGTGTCGTATTAAAAGAGCGTTTCGGAGTATGGGGCAATATCCTGGCT AATAATCTTCATGATGAAGTAAATCGTGTTGGAGTTTATACAGTGAGACCCTATGATCCAACCCCTAATA CAACAGAGGCTCCGTCTCGAGCACGTGGGGATGGGAAATTTGATACCTGCCTTAATCAATTTAACCGTTT AGCTTGCCTAAACGGTATGACCGCATCACTAAAGGACATCAATCAAGTATTATCAGGAGGTGTAATACCG GAGCAAAAAAAATTCGGTGGTTTGGTGCATATGCCCGACGTTGATTTTAACTCAAGACAACATCAACCAT TGCTGGTTTTAAGTAAAGGAAAAGTATATTACCGCAACAATCTCAGTCAAATTCACATAATTTCTCCTTC TGAATATGAGGCACTCAGAGAAAACCCTGAAAAACATGGGTATAAAGAGCTAACCAGTAAATGGGCTGCC TTTAAATTAGTTACCAAATTACGTCTCTTTCCTTATCTTTATGACGGCTCGGTTATGCCTGTTTCTGATG AAAAGCTCGCCGAAATTATCGCAGATGAAAAACGCAGAAATCCACAACGAGCTCCCATCCCCACACCATC ATGCCTTCCGGAAAGCGAACCAACTGTATTCGATTGGCGAACAAAAGCGAGCTGGCGTAATAATAAAGAC TCTCTGGATATTTTGGATGGGTTAAAGAAACACAGTATTTTGGCAGCAAAACAAACCCATTCGGCCATTC AAGAGGAAGAAGAGGTCCGGTTGAATTTGGGAGTCTGA |
| Reference |
(1) Aurass P et al. (2013). The Legionella pneumophila Dot/Icm-secreted effector PlcC/CegC1 together with PlcA and PlcB promotes virulence and belongs to a novel zinc metallophospholipase C family present in bacteria and fungi. J Biol Chem. 288(16):11080-92. [PudMed:23457299] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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(4) Altman E; Segal G (2008). The response regulator CpxR directly regulates expression of several Legionella pneumophila icm/dot components as well as new translocated substrates. J Bacteriol. 190(6):1985-96. [PudMed:18192394]
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| experimental literature |
| in silico analysis literature |