SecReT4
Effector Protein ID: 49476023
T4SS name [ID]VirB [2]
Gene symbol-
Locus tagBH13390
StrainBartonella henselae str. Houston-1
Repliconchromosome [GenBank: NC_005956] [Browse all T4SS(s) in this replicon]
Location [Strand]1525994..1527622 [+]
Producthypothetical protein
Effector typeProtein
DescriptonBepB
T4CP requirementT4CP Depedent
Target/EffectionThe Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells.
UniProt IDQ6G2A7
KEGG IDbhe:BH13390
PDB IDNA
Domain hit(s) vs Pfam Fic [PF02661], Evalue: 1.5e-16, Aligned region: 60..172
Protein Sequence: 542 a.a.     [Download]
>gi|49476023|ref|YP_034064.1| hypothetical protein BH13390 [Bartonella henselae str. Houston-1]
MPKAKAKNISTASPHNYIYPGTQILKNKYGETDLKLLLEKCLHDREQAMMNLRAESLPEYFDCAYLCYIH
QQLFQKTFEWAGHLRHTPFTFADGSIAAMPEMKRTEWGKDFAKSEKIPELLQKLDQELAEKDNLQGLTRE
EFIKQATELFYSLHKIHPFIDGNEHTEQFFFENLAKAAGHQLDFSLVTQKRMMAVCSEAMQYGDTQLMKD
LFEDISNPEKIRLLKDFMNNINNTGRNVNDCLVMVTKAGETYRGTYQGCYSEAFVLDMQGTYIIGKKDDL
TPERLKSLKPGDTITFIAPKNKELENTLIPKETLAPLTKSECARTVAQTSHVLTAQKKVRQHSKIVYGNA
NTLNEQIEEITKNPELGQLLADQIRQTPHSLSPLAGFSLCGLQNPARANARNHLDALATTVANYAHIVEH
TYHVITQKHQIEQERLGKTVEKPSQNLQNLFALSPEQQREILSQSPQLYQELRTFICCVEHRLSSNEWSA
IKNKDYETLAQSIGVSEQTAREITNTVQKARELHKQVYTHAITRSNTLAIAS
-
Nucleotide Sequence: 1629 bp     [Download]
>gi|49474831|ref|NC_005956.1|:1525994-1527622 Bartonella henselae str. Houston-1 chromosome, complete genome
ATGCCAAAAGCAAAAGCAAAAAATATCTCCACCGCTTCTCCCCATAATTATATCTATCCTGGTACCCAAA
TACTCAAAAATAAATATGGAGAAACAGATTTAAAACTCCTTCTGGAAAAATGCTTACATGATAGGGAACA
AGCAATGATGAATCTGCGTGCAGAATCCCTACCAGAATATTTTGATTGCGCTTATCTATGCTATATCCAC
CAACAATTGTTTCAAAAAACCTTTGAATGGGCTGGCCATCTCCGCCACACTCCCTTCACATTTGCAGATG
GTAGCATTGCCGCCATGCCAGAAATGAAAAGAACAGAATGGGGCAAAGATTTTGCAAAAAGTGAAAAAAT
CCCCGAACTTTTACAAAAATTAGATCAAGAGCTTGCCGAAAAAGACAATTTGCAAGGCTTAACACGCGAA
GAGTTTATCAAGCAAGCAACGGAGCTATTTTATTCTCTTCACAAAATCCACCCATTCATAGATGGCAATG
AACACACAGAACAATTCTTTTTTGAAAATCTCGCCAAAGCCGCCGGACATCAACTTGACTTTTCGCTTGT
CACACAAAAACGCATGATGGCAGTCTGTAGCGAAGCAATGCAATATGGCGATACACAACTGATGAAAGAT
CTTTTTGAAGATATCTCCAATCCAGAAAAAATACGTCTTTTAAAAGACTTTATGAACAACATCAACAATA
CAGGACGCAACGTGAATGATTGCCTTGTTATGGTGACAAAGGCAGGAGAAACCTACAGAGGAACCTATCA
AGGTTGTTATTCAGAAGCTTTTGTGCTCGATATGCAAGGGACTTACATCATCGGCAAAAAAGATGATCTC
ACACCAGAACGATTAAAATCATTAAAACCTGGTGATACAATTACCTTTATCGCCCCCAAAAACAAAGAGC
TTGAAAACACGCTCATTCCAAAAGAGACATTAGCGCCTCTAACAAAAAGTGAATGTGCCAGAACGGTTGC
GCAAACTAGCCATGTCCTCACAGCTCAAAAGAAAGTCCGGCAACACTCAAAAATTGTTTATGGCAATGCA
AACACATTAAACGAACAAATAGAAGAGATTACTAAAAATCCAGAATTAGGTCAACTGCTCGCCGATCAGA
TTAGACAAACACCGCACTCTCTTTCTCCTCTTGCAGGTTTCAGTCTATGCGGTTTACAAAATCCGGCACG
TGCAAACGCTCGAAATCATCTTGATGCACTCGCTACTACAGTTGCAAATTATGCACATATTGTAGAACAT
ACATATCATGTAATCACTCAAAAACATCAAATTGAACAAGAACGCCTTGGTAAAACAGTAGAAAAGCCCA
GTCAAAACTTGCAAAACCTTTTTGCCTTATCACCGGAACAACAAAGAGAAATCTTGTCTCAATCTCCTCA
ATTATACCAAGAGCTCCGTACTTTTATATGCTGTGTAGAGCATCGTCTCTCATCAAACGAGTGGAGTGCG
ATCAAAAACAAAGATTATGAAACACTTGCTCAAAGTATCGGTGTATCAGAACAGACAGCACGAGAGATTA
CCAATACTGTTCAAAAAGCCAGAGAGTTACATAAACAAGTCTACACACACGCAATCACTCGCTCAAATAC
GCTTGCTATTGCCAGCTAA

Reference
(1) Truttmann MC; Misselwitz B; Huser S; Hardt WD; Critchley DR; Dehio C (2011). Bartonella henselae engages inside-out and outside-in signaling by integrin beta1 and talin1 during invasome-mediated bacterial uptake. J Cell Sci. 124(Pt 21):3591-602. [PudMed:22045736] experimental
(2) Scheidegger F; Quebatte M; Mistl C; Dehio C (2011). The Bartonella henselae VirB/Bep system interferes with vascular endothelial growth factor (VEGF) signalling in human vascular endothelial cells. Cell Microbiol. 13(3):419-31. [PudMed:21044238] experimental
(3) Scheidegger F; Ellner Y; Guye P; Rhomberg TA; Weber H; Augustin HG; Dehio C (2009). Distinct activities of Bartonella henselae type IV secretion effector proteins modulate capillary-like sprout formation. Cell Microbiol. 11(7):1088-101. [PudMed:19416269] experimental
(4) Rhomberg TA; Truttmann MC; Guye P; Ellner Y; Dehio C (2009). A translocated protein of Bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome. Cell Microbiol. 11(6):927-45. [PudMed:19302579] experimental
(5) Schulein R; Guye P; Rhomberg TA; Schmid MC; Schroder G; Vergunst AC; Carena I; Dehio C (2005). A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells. Proc Natl Acad Sci U S A. 102(3):856-61. [PudMed:15642951] experimental
 
experimental experimental literature