| Effector Protein ID: 49476021 |
 T4SS name [ID] | VirB [2] |
| Gene symbol | - |
| Locus tag | BH13370 |
| Strain | Bartonella henselae str. Houston-1 |
| Replicon | chromosome [GenBank: NC_005956] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1521736..1523370 [+] |
| Product | cell filamentation protein |
| Effector type | Protein |
| Descripton | BepA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. |
| UniProt ID | Q6G2A9 |
| KEGG ID | bhe:BH13370 |
| PDB ID | 2JK8, 2VY3, 2VZA |
| Domain hit(s) vs Pfam | Fic [PF02661], Evalue: 2.7e-17, Aligned region: 62..176 |
| Protein Sequence: 544 a.a. [Download] |
| >gi|49476021|ref|YP_034062.1| cell filamentation protein [Bartonella henselae str. Houston-1] MPKAKAKTKNTEIISPHHYVYPNTTTLKNKYGIKNLNAFLEKCSHDTAKAMINLREESLPEYFDTAYLCH IHQQLFKNTFEWAGYLRHIPFTFADGTTAAMPEMKRTGWKNAFAIGDEIQEGLQRLDQTLAEKNNLQGLT REEFNSEAIELFNSLNQLHPFREGNGRTQRLFFENLAKAAGHQLNFSLITKERMMVASVAVAENGDLEPM QHLFEDISNPEKIRLLKEFMHTMKNTGRNVNDRPVMVAKEGETYTGTYRGAGLEGFALNVKGAYIIGNID HLPPEQLKILKPGDKITFTAPKAEELKKTLIPKETLVPLTKLEIAEMVAEDAFVHTCRDQICSLSKIVYG SQGVLNKNIIEIIKNPSKGQQLATQIERTPYSVHSLAGFDLICFKTGARVRAEKHVALLSCAVANFTHAV KHARQEITKEHQAEQNRLRQEVPMPSQSLQDLLSLPKEFQQKALGVSPLLQKELTSLLQKVNSRLSSSEQ RALRENNHETLAKNLGVSEQKAKEITKTVMKAREVQQKSQTRTVSHSKTLAMAS |
| - |
| Nucleotide Sequence: 1635 bp [Download] |
| >gi|49474831|ref|NC_005956.1|:1521736-1523370 Bartonella henselae str. Houston-1 chromosome, complete genome ATGCCAAAGGCAAAAGCAAAAACGAAAAATACAGAAATTATTTCCCCCCATCATTATGTCTATCCTAACA CCACAACACTCAAAAATAAATATGGAATAAAAAACTTAAATGCTTTTCTGGAAAAATGCTCGCATGATAC AGCCAAAGCAATGATCAATCTGCGTGAAGAATCCTTACCAGAATATTTTGATACCGCCTATCTATGCCAT ATTCATCAACAGTTGTTTAAAAATACATTTGAATGGGCTGGATACCTTCGCCATATCCCCTTCACATTTG CAGATGGCACCACAGCCGCCATGCCAGAAATGAAAAGAACGGGTTGGAAAAATGCTTTTGCAATTGGTGA TGAGATCCAAGAAGGCTTGCAAAGATTAGATCAAACACTTGCCGAAAAAAACAATTTACAAGGTTTAACG CGCGAAGAATTTAACTCTGAAGCAATAGAACTGTTTAATTCTCTCAACCAACTCCACCCATTCAGAGAAG GGAATGGACGAACACAACGGCTATTTTTTGAAAATCTTGCCAAAGCAGCAGGACATCAGCTTAACTTCTC GCTTATCACAAAAGAACGCATGATGGTTGCCAGTGTTGCGGTAGCAGAAAATGGTGACCTAGAACCTATG CAACATTTGTTTGAGGATATCTCCAATCCAGAAAAAATTCGTCTTTTAAAAGAATTTATGCACACCATGA AAAATACTGGGCGCAATGTTAATGATCGTCCTGTTATGGTTGCAAAGGAAGGGGAAACTTACACGGGCAC CTATAGAGGTGCTGGTCTTGAAGGTTTTGCACTCAATGTAAAAGGTGCTTACATTATCGGCAATATAGAC CACCTCCCACCAGAACAACTAAAAATATTAAAACCTGGTGATAAAATTACCTTTACAGCTCCAAAAGCCG AAGAATTAAAAAAAACACTCATCCCAAAAGAGACATTAGTTCCTTTGACAAAACTTGAAATAGCTGAAAT GGTTGCAGAAGATGCTTTTGTCCACACATGTCGAGACCAAATTTGCAGTCTATCAAAAATTGTTTATGGC AGCCAAGGTGTTTTGAATAAAAACATAATAGAAATCATTAAAAATCCAAGCAAGGGTCAGCAACTCGCCA CACAAATTGAAAGAACACCTTACTCTGTTCATAGTCTTGCAGGTTTTGACCTCATTTGCTTTAAAACTGG GGCACGGGTACGTGCTGAAAAGCATGTTGCACTCCTCAGTTGTGCAGTTGCAAATTTTACCCATGCAGTA AAACATGCAAGACAAGAAATCACAAAAGAACATCAAGCAGAACAAAACCGCCTTAGACAAGAGGTCCCTA TGCCAAGTCAAAGTTTGCAAGATCTTCTTTCCCTGCCAAAAGAGTTCCAGCAAAAAGCCTTAGGGGTCTC TCCTCTGCTTCAAAAAGAGCTCACGAGTCTTTTACAAAAAGTCAATAGCCGTCTCTCCTCAAGTGAACAA AGAGCACTTAGAGAAAATAATCATGAGACACTGGCGAAAAATCTTGGTGTTTCAGAACAGAAAGCAAAGG AAATTACAAAAACTGTTATGAAAGCCAGAGAAGTACAGCAAAAATCGCAAACACGCACAGTCAGTCACTC AAAAACGCTTGCCATGGCTAGCTAA |
| Reference |
(1) Truttmann MC; Misselwitz B; Huser S; Hardt WD; Critchley DR; Dehio C (2011). Bartonella henselae engages inside-out and outside-in signaling by integrin beta1 and talin1 during invasome-mediated bacterial uptake. J Cell Sci. 124(Pt 21):3591-602. [PudMed:22045736] 
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(2) Paschos A; den Hartigh A; Smith MA; Atluri VL; Sivanesan D; Tsolis RM; Baron C (2011). An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun. 79(3):1033-43. [PudMed:21173315]
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(3) Scheidegger F; Quebatte M; Mistl C; Dehio C (2011). The Bartonella henselae VirB/Bep system interferes with vascular endothelial growth factor (VEGF) signalling in human vascular endothelial cells. Cell Microbiol. 13(3):419-31. [PudMed:21044238]
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(4) Scheidegger F; Ellner Y; Guye P; Rhomberg TA; Weber H; Augustin HG; Dehio C (2009). Distinct activities of Bartonella henselae type IV secretion effector proteins modulate capillary-like sprout formation. Cell Microbiol. 11(7):1088-101. [PudMed:19416269]
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(5) Rhomberg TA; Truttmann MC; Guye P; Ellner Y; Dehio C (2009). A translocated protein of Bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome. Cell Microbiol. 11(6):927-45. [PudMed:19302579]
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(6) Schmid MC; Scheidegger F; Dehio M; Balmelle-Devaux N; Schulein R; Guye P; Chennakesava CS; Biedermann B; Dehio C (2006). A translocated bacterial protein protects vascular endothelial cells from apoptosis. PLoS Pathog. 2(11):e115. [PudMed:17121462]
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(7) Schulein R; Guye P; Rhomberg TA; Schmid MC; Schroder G; Vergunst AC; Carena I; Dehio C (2005). A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells. Proc Natl Acad Sci U S A. 102(3):856-61. [PudMed:15642951]
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| experimental literature |