| Effector Protein ID: 319898808 |
 T4SS name [ID] | VirB [231] |
| Gene symbol | - |
| Locus tag | BARCL_0640 |
| Strain | Bartonella clarridgeiae 73 |
| Replicon | chromosome [GenBank: NC_014932] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 702829..704481 [-] |
| Product | Bartonella effector protein (Bep); substrate of VirB T4SS |
| Effector type | Protein |
| Descripton | BepA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Homologous to BepA protein of Bartonella henselae. The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. |
| UniProt ID | E6YHI3 |
| KEGG ID | bcd:BARCL_0640 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Fic [PF02661], Evalue: 4.3e-16, Aligned region: 63..176 |
| Protein Sequence: 550 a.a. [Download] |
| >gi|319898808|ref|YP_004158901.1| Bartonella effector protein (Bep); substrate of VirB T4SS [Bartonella clarridgeiae 73] MVKRLQNALRRNKNSSCDYTYSGSNTLKNKHGIQDSLYLDKKSQLLSEKIAVQLRQEPLPKNFDSSYLKY LHKCLFEEMFEWAGHTRDLPFTFADGTTAEMVNVTIPNSDVFFQESQKIAKSLQKFDQALIEKKQLKDLS REKFVEEAVKLFSFLNYVHPFRDGNGRAQRMFFEKLAEAAGHQLDFSIATKQRMTFACRDAIPVKGNVNY KTMQHLFEDISNPKKVHILRNFLCSLPQYERNYMDSHVVIVPRDNVIYTGRYKNSSSDSIIIVTKDSYIV CCKDHLTPEKLKTLKCGDTVTFAIPGNKDLDQILIPAEKLAPLKKEELLEKIRNDTAIQNCEKEIKHLSK LVYGNSQKLNRSIEFIKQTAEDNEKTSNWLLKHLSTGDDLAGLTICGIKTPKRRTAERNILPLNQKIRTY ISIVESSKNKIMQNHHLEQKRLENSVEMPSKAVQDILVMPQDIRRQKLTSKNCIELQKELCHFLCKVNSR LSKDQSKAIRKGNYKEIAESIGMSESKAQTLIVIFNETREVYQQLQKIKMNRSTQMAMAI |
| - |
| Nucleotide Sequence: 1653 bp [Download] |
| >gi|319898193|ref|NC_014932.1|:c704481-702829 Bartonella clarridgeiae 73, complete genome ATGGTAAAAAGACTACAGAATGCTTTAAGAAGAAATAAAAATTCATCTTGTGATTATACTTATTCTGGCA GTAACACATTAAAAAATAAACATGGAATCCAAGATTCTCTGTATCTTGACAAAAAAAGTCAGTTGCTTTC AGAGAAAATAGCTGTTCAGTTACGTCAAGAGCCATTACCAAAAAACTTTGATTCTTCCTATTTGAAATAT CTTCATAAATGCTTATTTGAGGAAATGTTTGAATGGGCTGGACATACCCGCGATCTTCCATTTACATTTG CAGATGGCACAACTGCCGAAATGGTAAATGTAACAATACCAAACTCAGATGTTTTTTTTCAAGAGAGTCA AAAAATTGCAAAAAGCTTACAGAAATTTGATCAAGCTCTCATTGAGAAGAAACAATTAAAAGATTTATCG CGTGAAAAATTTGTCGAGGAGGCAGTAAAGCTTTTTTCTTTTCTCAATTATGTACATCCATTCAGAGATG GTAATGGACGTGCACAACGAATGTTTTTTGAAAAGCTTGCAGAAGCTGCAGGTCATCAACTTGATTTTTC AATTGCTACAAAACAACGCATGACATTTGCCTGTAGAGATGCAATACCTGTAAAAGGTAATGTAAATTAT AAAACGATGCAACATCTTTTCGAAGATATCTCTAATCCAAAAAAAGTGCATATTTTAAGGAATTTTTTAT GCTCTTTGCCTCAATATGAACGTAATTATATGGATAGTCACGTTGTTATAGTACCACGTGATAATGTAAT CTATACGGGTAGATATAAAAATAGTAGTTCAGATTCTATTATAATTGTAACAAAAGATTCATATATTGTA TGCTGTAAAGATCATTTAACACCAGAAAAACTGAAGACATTAAAATGCGGTGATACAGTTACCTTTGCAA TTCCAGGAAATAAAGATTTAGATCAAATTCTCATTCCAGCAGAAAAATTAGCTCCTTTAAAGAAAGAAGA GTTACTCGAAAAGATTAGAAACGATACTGCGATTCAAAACTGCGAAAAAGAAATCAAACATTTATCAAAA CTTGTCTATGGCAATTCACAAAAGTTAAATCGCAGTATAGAGTTTATTAAGCAAACAGCAGAAGATAATG AAAAAACCTCTAACTGGCTTTTAAAGCATCTTTCTACCGGCGATGATCTTGCGGGTTTAACAATATGCGG CATAAAAACTCCAAAACGCAGAACAGCTGAAAGAAATATTTTACCACTCAATCAAAAAATTCGAACATAT ATTTCTATTGTAGAATCTTCTAAAAATAAAATTATGCAAAATCATCATTTAGAACAAAAACGGCTTGAAA ATTCAGTAGAAATGCCTAGCAAAGCAGTGCAGGATATTCTTGTTATGCCACAGGATATAAGGAGACAAAA GTTAACCTCAAAGAATTGTATTGAACTTCAAAAAGAGCTTTGTCATTTTTTGTGTAAAGTCAATTCTCGT CTTTCAAAAGACCAGAGTAAAGCAATCAGAAAAGGTAATTATAAAGAAATCGCTGAAAGCATTGGTATGT CAGAAAGTAAAGCACAAACTCTTATAGTAATTTTTAATGAAACAAGAGAAGTATACCAACAACTTCAAAA AATCAAAATGAATAGGTCAACACAGATGGCTATGGCTATCTAA |
| Reference |
(1) Engel P; Salzburger W; Liesch M; Chang CC; Maruyama S; Lanz C; Calteau A; Lajus A; Medigue C; Schuster SC; Dehio C (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genet. 7(2):e1001296. [PudMed:21347280]  
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| experimental literature |
| in silico analysis literature |