| Effector Protein ID: 308184331 |
 T4SS name [ID] | Cag [32] |
| Gene symbol | - |
| Locus tag | HPSJM_02765 |
| Strain | Helicobacter pylori SJM180 |
| Replicon | chromosome [GenBank: NC_014560] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 549621..553166 [+] |
| Product | cag pathogenicity island protein (cag26) |
| Effector type | Protein |
| Descripton | CagA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | CagA can cause gastritis and peptic ulcer, Injected CagA can act as a ‘master key’ that evolved the ability to highjack multiple host cell signalling cascades, which include the induction of membrane dynamics, actin-cytoskeletal rearrangements and the disruption of cell-to-cell junctions as well as proliferative, pro-inflammatory and anti-apoptotic nuclear responses (Backert et al, 2010). |
| UniProt ID | E1PZ06 |
| KEGG ID | hpm:HPSJM_02765 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | CagA [PF03507], Evalue: 1e-110, Aligned region: 864..1053 |
| Protein Sequence: 1181 a.a. [Download] |
| >gi|308184331|ref|YP_003928464.1| cag pathogenicity island protein (cag26) [Helicobacter pylori SJM180] MTNETIDQQPQTEAAFNPQQFINNLQVAFLKLDNAVASFDPDQKPIVDKNDRDNRQAFDGISQLREEYSN KAIKNPTKKNQYFSDFINKSNDLINKDALIDVESSTKSFQKFGDQRYRIFTSWVSHQNDPSKINTRSIRN FMEHTIQPPIPDDKEKAEFLKSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGGPSGGDWLDI FLSFIFDKKQSSDVKEAINQEPVPHVQPDIATTTTDIQGLPPESRDLLDERGNFSKFTLGDMNMLDVEGV ADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYAGNGGFGAKHDWNATVGYKDQQGNNVATIIN VHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIRNKIDFMEFLAQNNAKLDNLSEKEKEK FRNEIKDFQKDSKAYLDALGNDRIAFVSKKDPKHSALITEFNKGDLSYTLKDYGKKADKALDREKNVTLQ GNLKHDGVMFVDYSNFKYTNASKNPNKGVGATNGVSHLDAGFSKVAVFNLPDLNNLAINSFVRRNLEDKL VAKGLPPQEANKLIKDFLSSNKELVGKALNFNKAVADAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVEK KLESKSGNKNKMEAKAQANSQKDEIFALINKEANRDARAITYSQNLKGIKRELSDKLESINKDLKDFSKS FDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNDFKNGKNKDFSKVTQAKIDLENS IKDTIINQKITDKVDDLNQAVSVAKATGDFSRVEQALADLKNFSKEQLAQQTQKNESFNVGKKSEIYQSV KNGVNGTLVGNGLSQVEATTLSKNFSDIKKELNAKLFGNFNNNNNNGLKNEPIYAKVNKKKTEQAASPEE PIYTQVAKKVTQKIDRLNQIASGLGGVGQAAGFPLKRHDKVEDLSKVGRSVSPEPIYATIDDLGGPFPLK RHDKVDDLSKVGLSREQQLKQKIDNLSQAVSEAKAGFFGNLEQTIDKLKDSTKHNPMNLWVESAKKVPTS LSAKLDNYATNSHTRINSNIKNGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSVPLSEYDKIGFNQKN MKDYSDSFKFSTKLNNAVKDVKSGFTQFLANAFSTGYYCLAGENAEHGIKNVNTKGGFQKS |
| - |
| Nucleotide Sequence: 3546 bp [Download] |
| >gi|308183796|ref|NC_014560.1|:549621-553166 Helicobacter pylori SJM180 chromosome, complete genome ATGACTAACGAAACTATTGACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAATA ACCTTCAGGTAGCTTTTCTTAAGCTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGT TGATAAGAATGATAGGGATAACAGGCAAGCTTTTGATGGAATCTCGCAATTAAGGGAAGAATACTCCAAT AAAGCGATCAAAAATCCTACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTAA TCAACAAAGACGCTCTCATTGATGTAGAATCTTCCACAAAGAGCTTTCAGAAATTTGGGGATCAGCGTTA CCGAATTTTCACAAGTTGGGTGTCCCATCAAAACGATCCGTCTAAAATCAACACCCGATCGATCCGAAAT TTTATGGAACATACCATACAACCCCCTATCCCTGATGACAAAGAAAAAGCAGAGTTTTTGAAATCTGCCA AACAATCTTTTGCAGGAATCATTATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGGCGTGTTTGA TGAATCCTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGGGCCTAGTGGTGGGGATTGGTTGGATATT TTTTTATCATTTATATTTGACAAAAAACAATCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTC CCCATGTCCAACCAGATATAGCCACTACCACCACCGACATACAAGGCTTACCACCTGAATCTAGGGATTT GCTTGATGAAAGGGGTAATTTTTCTAAATTCACTCTTGGTGATATGAACATGTTAGATGTTGAGGGAGTC GCTGACATTGATCCCAATTACAAGTTCAATCAATTATTGATTCACAATAACGCTCTGTCTTCTGTGTTAA TGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGCGGGCAATGGTGGTTTTGGAGC CAAGCACGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTGGCCACAATAATTAAT GTGCATATGAAAAACGGCAGTGGCTTAGTCATAGCAGGTGGTGAGAAAGGGATTAACAACCCTAGTTTTT ATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGTCAAGAAGAGATCCGAAACAAAAT AGATTTCATGGAATTTCTTGCACAAAACAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAA TTCCGAAATGAGATTAAGGATTTTCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTA TTGCTTTTGTTTCTAAAAAAGACCCAAAACATTCAGCTTTAATTACTGAGTTTAATAAGGGGGATTTGAG CTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCTTTAGATAGGGAGAAAAATGTCACTCTTCAA GGTAACCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAAATACACCAACGCCTCCAAGA ATCCCAATAAGGGTGTCGGCGCTACGAATGGCGTTTCCCATTTAGACGCAGGCTTTAGCAAGGTAGCTGT CTTTAATTTGCCTGATTTAAATAATCTCGCTATCAATAGTTTCGTAAGGCGGAATTTAGAGGATAAACTA GTCGCTAAAGGATTGCCCCCACAAGAAGCTAATAAGCTTATCAAAGATTTTTTGAGCAGCAACAAAGAAT TGGTTGGAAAGGCTTTAAACTTCAATAAAGCTGTAGCTGACGCTAAAAACACAGGCAACTATGACGAGGT GAAAAAAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGAGAAA AAATTGGAGAGCAAAAGCGGCAACAAAAATAAAATGGAAGCAAAAGCTCAAGCTAACAGCCAGAAAGATG AGATTTTTGCGTTGATCAATAAAGAGGCTAATAGAGACGCAAGAGCAATCACTTACAGTCAAAATCTTAA AGGTATCAAAAGGGAATTGTCTGATAAGCTTGAAAGCATCAACAAGGATTTGAAAGACTTTAGTAAATCT TTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACACTAAAAGCCCTTAAAG GCTCGGTGAAAGATTTAGGTATCAATCCGGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAA TGACTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAATCGACCTTGAAAATTCC ATTAAAGATACGATTATCAATCAAAAGATAACGGATAAAGTTGATGATCTCAATCAAGCGGTATCAGTGG CTAAAGCAACGGGTGATTTCAGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAATTTCTCAAAGGAGCA ATTGGCTCAACAAACTCAAAAAAATGAAAGTTTCAATGTTGGGAAAAAATCTGAAATATACCAGTCCGTT AAGAATGGTGTGAACGGAACCCTAGTCGGTAATGGGTTATCTCAAGTAGAAGCCACAACTCTTTCTAAAA ACTTTTCGGACATCAAGAAAGAGTTGAATGCAAAACTTTTTGGAAATTTTAATAACAATAACAATAATGG ACTCAAAAACGAACCCATTTATGCTAAAGTTAATAAAAAGAAAACAGAACAAGCAGCTAGCCCTGAAGAA CCCATTTATACTCAAGTTGCTAAAAAGGTAACTCAAAAAATTGACCGACTCAATCAAATAGCAAGTGGTT TGGGTGGTGTAGGGCAAGCAGCGGGCTTCCCTTTGAAAAGGCATGATAAAGTTGAAGATCTCAGTAAGGT AGGGCGATCAGTTAGCCCTGAACCCATTTATGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAA AGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAAGGGAGCAACAATTGAAACAGAAGATTG ACAATCTCAGTCAAGCGGTATCAGAAGCTAAAGCAGGTTTTTTTGGCAATCTAGAGCAAACGATAGACAA GCTCAAAGATTCTACAAAACACAATCCCATGAATCTATGGGTTGAAAGTGCAAAAAAAGTGCCTACTAGT TTGTCAGCGAAACTAGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATATCAAAAATGGAG CAATCAATGAAAAAGCGACCGGCATGCTGACGCAAAAAAATCCTGAGTGGCTCAAGCTCGTGAATGATAA GATAGTTGCGCATAATGTGGGAAGCGTTCCTTTGTCAGAGTATGATAAAATTGGCTTCAACCAGAAGAAT ATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCTGTAAAAGACGTTAAATCTG GCTTTACGCAATTTTTAGCCAATGCATTTTCTACAGGATATTACTGCTTGGCGGGAGAAAATGCGGAGCA TGGAATCAAAAATGTTAATACAAAAGGTGGTTTCCAAAAATCTTAA |