| Effector Protein ID: 308182704 |
 T4SS name [ID] | Cag [33] |
| Gene symbol | - |
| Locus tag | HPPC_02715 |
| Strain | Helicobacter pylori PeCan4 |
| Replicon | chromosome [GenBank: NC_014555] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 534448..538050 [+] |
| Product | cytotoxin-associated protein A |
| Effector type | Protein |
| Descripton | CagA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | CagA can cause gastritis and peptic ulcer, Injected CagA can act as a ‘master key’ that evolved the ability to highjack multiple host cell signalling cascades, which include the induction of membrane dynamics, actin-cytoskeletal rearrangements and the disruption of cell-to-cell junctions as well as proliferative, pro-inflammatory and anti-apoptotic nuclear responses (Backert et al, 2010). |
| UniProt ID | E1Q638 |
| KEGG ID | hpc:HPPC_02715 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | CagA [PF03507], Evalue: 6e-118, Aligned region: 864..916 CagA [PF03507], Evalue: 6e-118, Aligned region: 910..1072 |
| Protein Sequence: 1200 a.a. [Download] |
| >gi|308182704|ref|YP_003926831.1| cytotoxin-associated protein A [Helicobacter pylori PeCan4] MTNETIDQQPQTGAAFNPQQFINNLQVAFLKLDNAVASFDPDQKPIVDKNDRDNRQAFDGISQLREEYSN KAIKNPTKKNQYFSDFINKSNDLINKDNLIDVESSTKSFQKFGDQRYRIFTSWVSHQNDPSKINTRSIRN FMENIIQPPIHDDKEKAEFLKSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGEPTGGDWLDI FLSFIFNKKQSSDVKEAINQEPVPHVQPDIATSTTHIQGLPPESRDLLDERGNFSKFTLGDMEMLDVEGV ADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYAGNGGFGAKHDWNATVGYKDQQGNNVATIIN VHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIQNKVDFMEFLAQNNAKLDNLSEKEKEK FRTEIENFQKNPKAYLDALGNDRIAFVSKKDPKHSALITEFGKGDLSYTLKDYGKKADKALDREKNVTLQ GSLKHDGVMFVDYSNFKYTNASKNPNKGVGVTNGVSHLDAGFSKVAVFNLPDLNNLAITSFVRRNLEDKL TAKGLSLQEANKLIKDFLSSNKELVGKALNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVEK KLESKSGNKNKMEAKSQANSQKDEIFALINKEANRDARAIAYSQNLKGIKRELSDKLESINKDLKDFSKS FDALKSGKNKDFSNAEETLKALKSSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENS VKDVIINQKVTDKVDDLNQAVSVAKATGDFSRVEQALADLKNFSKEQLVQQAQKNESFNVGKKSEIYQSV KNGVNGTLVGNGLSQAEATTLSKNFSDIKKELNAKLFGNNNNNNNNGLKNEPIYAKVNKKKTGQVASPEE PIYAKVNKKKTGQVASPEEPIYAQVAKKVNAKIDRLNQIASGLGGVGQAAGFPLKRHDKVDDLSKVGRSV SPEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSREQKLAQKIDNLNQAVSEAKAGFFGNLEQTIDKLKDS TKNNTVNLWAESAKKVPASLSAKLDNYATNSHTRINSNIHNGAINEKATGMLTQKNPEWLKLVNDKIVAH NVGSVPLSEYDKIGFNQKNMKDYSDSFKFSTKLNNAVKDVKSGFTQFLANAFSTGYYCLARENAEHGIKN VNTKGGFQKS |
| - |
| Nucleotide Sequence: 3603 bp [Download] |
| >gi|308182188|ref|NC_014555.1|:534448-538050 Helicobacter pylori PeCan4 chromosome, complete genome ATGACTAACGAAACTATTGACCAACAACCACAAACCGGAGCGGCTTTTAACCCGCAGCAATTTATCAATA ATCTTCAAGTAGCTTTTCTTAAGCTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGT TGATAAGAACGATAGGGATAACAGGCAAGCTTTTGATGGAATCTCGCAATTAAGGGAAGAATACTCCAAT AAAGCGATCAAAAATCCTACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTAA TCAACAAAGACAATCTCATTGATGTAGAATCTTCCACAAAGAGCTTTCAGAAATTTGGGGATCAGCGTTA CCGAATTTTCACAAGTTGGGTGTCCCATCAAAACGATCCGTCTAAAATCAACACCCGATCGATCCGAAAT TTTATGGAAAATATCATACAACCCCCTATCCATGATGACAAAGAAAAAGCAGAGTTTTTGAAATCTGCCA AGCAATCTTTTGCAGGAATCATCATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGGCGTGTTTGA TGAATCTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGAGCCTACTGGTGGGGATTGGTTGGATATT TTTCTCTCATTTATATTTAACAAAAAACAATCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTC CCCATGTCCAACCAGATATAGCCACTAGCACCACCCACATACAAGGCTTACCGCCTGAATCTAGGGATTT GCTTGATGAAAGGGGTAATTTTTCTAAATTCACTCTTGGCGATATGGAAATGTTAGATGTTGAGGGAGTT GCCGACATTGATCCTAATTACAAGTTCAATCAATTATTGATTCACAATAACGCTCTGTCTTCTGTGTTAA TGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGCGGGCAATGGTGGTTTTGGAGC CAAACACGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTGGCTACAATAATTAAT GTGCATATGAAAAACGGCAGTGGATTAGTCATAGCAGGTGGTGAGAAAGGGATTAATAATCCTAGTTTTT ATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGCCAAGAAGAGATCCAAAACAAAGT AGATTTCATGGAATTTCTTGCACAAAACAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAGGAAAAA TTCCGAACTGAGATTGAAAATTTCCAAAAAAACCCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTA TTGCTTTTGTTTCTAAAAAAGACCCAAAACATTCAGCTTTAATTACTGAGTTTGGTAAGGGGGATTTGAG CTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCTTTAGATAGGGAGAAAAATGTCACTCTTCAA GGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAAATACACCAACGCCTCCAAGA ATCCCAATAAGGGTGTAGGCGTTACGAATGGCGTTTCCCATTTAGACGCAGGCTTTAGCAAGGTAGCTGT CTTTAATTTGCCTGATTTAAATAATCTCGCTATCACTAGTTTCGTAAGGCGGAATTTAGAGGATAAACTA ACCGCTAAAGGATTGTCCCTACAAGAAGCTAATAAGCTTATCAAAGATTTTTTGAGCAGCAACAAAGAAT TGGTTGGAAAAGCTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAACTATGATGAAGT GAAAAAAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGAGAAA AAATTGGAGAGCAAAAGCGGCAACAAAAATAAAATGGAAGCAAAATCTCAAGCTAACAGCCAGAAAGATG AGATTTTTGCGTTGATCAATAAAGAGGCTAATAGGGACGCAAGAGCAATCGCTTACAGTCAAAATCTTAA AGGTATCAAAAGGGAATTGTCTGATAAGCTTGAAAGCATCAACAAGGATTTGAAAGACTTTAGTAAATCT TTTGATGCACTCAAAAGTGGCAAAAATAAGGATTTCAGCAATGCAGAAGAAACGCTAAAAGCCCTTAAAA GCTCGGTGAAAGATTTGGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAA TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATTCC GTTAAAGATGTGATCATCAATCAAAAGGTAACGGATAAAGTTGATGATCTCAATCAAGCGGTATCAGTGG CTAAAGCAACGGGTGATTTCAGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAATTTCTCAAAGGAGCA ATTGGTTCAACAAGCTCAAAAAAATGAAAGTTTCAATGTTGGAAAAAAATCTGAAATATACCAATCCGTT AAGAATGGTGTGAACGGAACCCTAGTCGGTAATGGGTTATCTCAAGCAGAAGCCACAACTCTTTCTAAAA ACTTTTCGGACATCAAGAAAGAGTTGAATGCAAAACTTTTTGGAAATAACAATAACAATAACAATAATGG ACTCAAAAACGAACCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAA CCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAACCCATTTACGCTC AAGTTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTGGTTTGGGTGGTGTAGG GCAAGCAGCGGGCTTCCCTTTGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCGATCAGTT AGCCCTGAACCCATTTATGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATGATAAAG TTGATGATCTCAGTAAGGTAGGGCTTTCAAGGGAGCAAAAATTGGCTCAGAAAATTGACAATCTCAATCA GGCGGTGTCAGAAGCTAAAGCAGGTTTTTTTGGCAATCTAGAGCAAACGATAGACAAGCTCAAAGATTCT ACAAAAAACAATACTGTGAATCTATGGGCTGAAAGTGCAAAAAAAGTGCCTGCTAGTTTGTCAGCGAAAT TGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATATCCACAATGGAGCAATCAATGAAAA AGCGACCGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAAATAGTTGCACAT AATGTAGGAAGCGTTCCTTTGTCAGAGTATGATAAAATTGGCTTCAACCAAAAGAATATGAAAGATTATT CTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCTGTAAAAGACGTTAAGTCTGGCTTTACGCAATT TTTAGCCAATGCATTTTCTACAGGATATTACTGCTTGGCGAGGGAAAATGCGGAGCATGGAATCAAAAAT GTTAATACAAAAGGTGGTTTCCAAAAATCTTAA |