| Effector Protein ID: 298736236 |
 T4SS name [ID] | Cag [34] |
| Gene symbol | cagA |
| Locus tag | HPB8_741 |
| Strain | Helicobacter pylori B8 |
| Replicon | chromosome [GenBank: NC_014256] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 716816..720370 [+] |
| Product | cytotoxin-associated protein A |
| Effector type | Protein |
| Descripton | CagA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | CagA can cause gastritis and peptic ulcer, Injected CagA can act as a ‘master key’ that evolved the ability to highjack multiple host cell signalling cascades, which include the induction of membrane dynamics, actin-cytoskeletal rearrangements and the disruption of cell-to-cell junctions as well as proliferative, pro-inflammatory and anti-apoptotic nuclear responses (Backert et al, 2010). |
| UniProt ID | D7FDP1 |
| KEGG ID | hpl:HPB8_741 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | CagA [PF03507], Evalue: 3e-114, Aligned region: 868..1056 |
| Protein Sequence: 1184 a.a. [Download] |
| >gi|298736236|ref|YP_003728762.1| cytotoxin-associated protein A [Helicobacter pylori B8] MTNETINQQPQTEAAFNPQQFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREKFAN KAIKNPTKKNQYFSNFISKSSDLINKDGLIDTGSSIKSFQKFGTQRYQIFMNWVSHQKDPSQINTQKIRG FMENIIQPPISDDKEKAEFLRSAKQALAGIIIRNQIRSDQKFMGVFDESLKERQEAEKNGEPNGDPTGGD WFDIFLSFVFNKKQSSDLKETLNQEPVPHVQPDVATTTTDIQSLPPESRDLLDERGNFSKFTLGDMEMLD VEGVADIDPNYKFNQLLVHNNALSSVLMGSHDGIEPEKVSLLYGNNGGPEARHDWNATVGHKNQQGNNVA TLINVHMKNGSGLVIAGGEKGVNNPSFYLYKEDQLTGLKQALSQKEIQNKVDFMEFLAQNNAKLDNLSKK EKEKFQNEIEDFQKDHKAYLDALGNDHIAFVSKKDKKHLALVTEFGSGDLSYTLKDYGKKADKALDREIK TTLQGSLKHDGVMFVDYSNFKYTNASKSPDKGVGATNGVSHLEANLSKVAVFNLPNLNNLAITSYIRRDL EEKLGAKGLSPQEANKLIKDFLNSNKELVGKVLNLNKAVAEAKNTGNYDEVKKAQKNLEKSLRKREHLEK EVVKKLENRNDNKNRMEAKAQANSQKDKIFAIINEEASKEARVAACVQKFKGIKMELSDKFENINKNLKD FDKSFDDFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNTALNDFKNGKNKDFSKVTQAKSD LENSIKDVIINQKITDKVDNLNQAVSVAKATGDFSGVEQALADLKNFSKGQLAQQAQKNEDFNTGKNSEL YQSVKNGVNGTLVGNGLSGIEATALTKNFSDIKKELNEKFKNFNNNNNGLKNSGEPIYAQVNKKKTGQVA SPEEPIYTQVAKKVKAKIDQFNQVASGLGGVGQAGFSLKGHTKVDDLSKVGRSVSPEPIYATIDDLGGPF PLKRHDKVDDLSKVGLSRNQELAQKIDNLNQAVSEAKACHFDNLDQMIDKLKDSTKKNVMNLYVESAKKV PTSLSAKLDNYAINSHTRINSNVKNGTINEKVTGMLTQKNPEWLKLVNDKIVAHNVGSVPLSEYDKIGFN QKNMKDYSDSFKFSTRLSNAVKDIKSGFVQFLTNTFSMGSYSLMKASVEHGVKNTNTKGGFQKS |
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| Nucleotide Sequence: 3555 bp [Download] |
| >gi|298735500|ref|NC_014256.1|:716816-720370 Helicobacter pylori B8 chromosome, complete genome ATGACTAACGAAACCATTAACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAATA ATCTTCAAGTGGCTTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGT TGATAAGAATGATAGGGATAACAGGCAAGCTTTTGAGAAAATCTCGCAGCTAAGGGAGAAATTCGCTAAT AAAGCGATCAAAAATCCTACCAAAAAGAATCAGTATTTTTCAAACTTTATCAGTAAGAGCAGTGATTTAA TCAACAAAGACGGTCTCATTGATACAGGTTCTTCCATAAAAAGCTTTCAGAAATTTGGGACTCAGCGTTA CCAAATTTTTATGAATTGGGTGTCCCATCAAAAAGATCCATCTCAAATCAACACCCAAAAAATCCGAGGT TTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAGAAAGCGGAGTTTTTGAGGTCTGCCA AACAAGCTCTTGCAGGAATTATCATAAGAAACCAAATCCGATCGGATCAAAAATTCATGGGCGTGTTTGA TGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGGAGAGCCTAATGGAGATCCTACTGGTGGGGAT TGGTTTGATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATC AAGAACCAGTTCCTCATGTCCAACCAGATGTAGCCACTACCACCACTGACATACAAAGCTTACCGCCTGA ATCTAGAGATTTACTTGATGAAAGGGGTAATTTTTCTAAATTCACTCTTGGCGATATGGAAATGTTAGAT GTTGAGGGAGTCGCTGACATTGATCCCAATTACAAGTTCAACCAATTATTGGTTCACAATAACGCTCTGT CTTCTGTGTTAATGGGGAGTCATGATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGGAAACAATGG TGGCCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTCATAAAAACCAACAAGGCAACAATGTGGCT ACACTCATTAATGTGCATATGAAAAACGGCAGTGGGTTAGTCATAGCAGGTGGTGAGAAAGGGGTTAACA ACCCTAGTTTTTATCTCTACAAAGAAGATCAGCTCACAGGCTTGAAACAAGCATTGAGTCAAAAAGAGAT CCAAAACAAAGTAGATTTCATGGAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCAAGAAA GAGAAAGAAAAATTCCAAAATGAGATTGAAGATTTTCAAAAAGACCATAAGGCTTATTTAGACGCCCTAG GGAATGATCACATTGCTTTTGTTTCTAAAAAAGACAAAAAACATTTAGCTTTAGTTACTGAGTTTGGTAG TGGGGACTTGAGCTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCTTTAGATAGGGAGATAAAA ACCACTCTTCAAGGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAAATACACCA ACGCCTCCAAGAGTCCTGATAAGGGTGTGGGTGCTACGAATGGCGTTTCCCATTTGGAAGCAAATCTTAG CAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAGTTATATAAGGCGAGACTTA GAAGAGAAACTGGGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACA GCAACAAGGAATTGGTTGGAAAAGTTTTAAACCTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAA TTATGACGAAGTGAAAAAAGCTCAGAAAAATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAA GAAGTAGTGAAAAAATTGGAGAACAGAAACGACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACA GCCAAAAAGATAAGATTTTTGCAATTATCAATGAAGAGGCTAGTAAGGAAGCAAGAGTGGCCGCTTGCGT TCAGAAGTTTAAAGGCATCAAAATGGAATTGTCTGATAAGTTTGAAAACATCAACAAGAATTTGAAAGAC TTTGATAAATCTTTTGATGACTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACGCTAA AAGCCCTTAAAGGCTCGGTGAAGGATTTAGGCATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAA TACAGCTTTGAATGACTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGAC CTTGAAAATTCCATTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAAG CGGTATCAGTGGCTAAAGCAACAGGCGATTTCAGTGGGGTAGAGCAAGCGCTAGCCGATCTCAAGAATTT CTCAAAAGGACAATTGGCTCAACAAGCTCAAAAAAATGAAGATTTCAATACTGGAAAAAATTCTGAACTA TACCAATCCGTTAAGAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTATCTGGAATAGAGGCCACAG CTCTCACCAAAAATTTTTCGGATATCAAGAAAGAATTGAATGAGAAATTTAAAAATTTCAATAACAATAA TAATGGTCTCAAAAACAGCGGAGAACCCATTTATGCTCAGGTTAATAAAAAGAAAACAGGACAAGTAGCT AGCCCTGAGGAACCCATTTATACTCAAGTTGCTAAAAAGGTAAAAGCAAAAATTGACCAATTCAATCAAG TAGCAAGTGGTTTGGGTGGTGTAGGGCAAGCGGGATTCTCTTTGAAAGGGCATACTAAAGTTGATGATCT CAGTAAGGTAGGGCGATCAGTTAGCCCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTC CCTTTGAAAAGGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAAGGAATCAAGAATTGGCTC AGAAAATTGACAATCTCAATCAGGCGGTATCAGAAGCTAAAGCATGTCATTTTGACAACCTAGATCAAAT GATAGACAAGCTCAAAGATTCTACAAAAAAGAATGTTATGAATCTATATGTTGAAAGTGCAAAAAAAGTG CCTACTAGTTTGTCAGCGAAATTGGACAATTATGCTATTAACAGCCACACACGCATTAATAGCAATGTCA AAAATGGAACAATCAATGAAAAAGTGACCGGCATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGT GAATGATAAGATAGTTGCACATAATGTGGGAAGCGTTCCTTTGTCAGAGTATGATAAAATTGGCTTCAAC CAGAAAAATATGAAAGATTATTCTGATTCATTCAAGTTTTCCACCAGGTTGAGCAATGCTGTAAAAGACA TTAAGTCTGGCTTTGTGCAATTTTTAACCAATACATTTTCTATGGGATCTTACAGCTTGATGAAAGCAAG TGTGGAACATGGAGTCAAAAATACTAATACAAAAGGTGGTTTCCAAAAATCTTAA |