| Effector Protein ID: 29655110 |
 T4SS name [ID] | Dot/Icm [157] |
| Gene symbol | - |
| Locus tag | CBU_1823 |
| Strain | Coxiella burnetii RSA 493 |
| Replicon | chromosome [GenBank: NC_002971] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1753253..1754302 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | IcaA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | caA is involved in the inhibition of certain cellular processes, which leads to caspase-11 activation. |
| UniProt ID | Q83AQ7 |
| KEGG ID | cbu:CBU_1823 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 349 a.a. [Download] |
| >gi|29655110|ref|NP_820802.1| hypothetical protein CBU_1823 [Coxiella burnetii RSA 493] MPKLSNRDLQNLRDSSKWSEETINTIYKRLMELICNINNESKQEDDEQQELGELLRLENVNQQTVLIYLA MKDPTKLIVLVENLKESHSREFMYAIKQKGKMDHNVLSCLLLYHPGKFPELIRLFDDERNISELFSGICS VATYNLSKENFDVVSINKLEALFYCAPDQQSLIKAALEALINQISSPYYKIELLSQLITRTRSHRKQRLI ENIYRDHLLSALLQVKKDVPSLVALSRLVSFSGKSYLKNVILSLKKAAPSNDEISYLSRLKSQAEGDEIS LIYYIVNYGRNSGKVKKPGTTATSQLLFEPPKTSTKTSQKFKRFLNLFLPREKILEEKEMAEWPTNKRP |
| - |
| Nucleotide Sequence: 1050 bp [Download] |
| >gi|77358712|ref|NC_002971.3|:1753253-1754302 Coxiella burnetii RSA 493 chromosome, complete genome ATGCCTAAACTCAGTAACCGTGACTTACAAAATCTCAGAGATTCTTCTAAATGGAGCGAAGAGACTATTA ACACCATCTACAAAAGATTAATGGAACTTATTTGCAATATAAATAATGAATCGAAACAAGAAGATGACGA GCAGCAAGAGTTGGGAGAGCTGCTTCGGTTGGAAAATGTTAATCAACAGACAGTTTTGATCTATTTAGCC ATGAAAGATCCTACAAAATTAATTGTTCTGGTAGAAAATCTTAAAGAATCCCATTCAAGAGAGTTCATGT ATGCCATCAAACAAAAAGGAAAAATGGATCACAATGTTCTATCGTGCTTATTACTCTATCATCCCGGAAA ATTTCCCGAATTGATACGGCTTTTCGATGATGAAAGGAACATAAGTGAATTATTTTCTGGAATTTGCTCA GTAGCTACCTATAACTTATCAAAAGAAAATTTTGACGTCGTTTCCATCAATAAACTAGAGGCCTTGTTTT ACTGTGCTCCAGATCAGCAGTCTTTAATAAAAGCGGCGTTAGAGGCTTTAATAAATCAAATTTCATCGCC CTATTATAAAATTGAACTTCTATCACAACTAATTACTCGTACTCGGTCTCACAGAAAACAACGACTCATT GAAAATATATACAGAGATCATTTACTATCCGCTTTGCTCCAAGTAAAAAAAGACGTACCTTCTTTGGTGG CTCTAAGCAGATTAGTCAGCTTTTCTGGTAAATCTTATCTCAAAAACGTGATACTAAGCTTAAAAAAAGC AGCCCCTTCTAACGATGAAATCAGCTATCTTAGTCGTCTTAAAAGTCAGGCTGAAGGAGATGAGATTTCT TTAATTTATTATATCGTAAACTATGGCCGAAATTCCGGAAAAGTCAAAAAACCAGGAACTACAGCAACCT CGCAATTATTATTTGAACCACCTAAAACTTCCACTAAAACTTCTCAAAAATTTAAACGGTTTTTGAATTT ATTTTTACCTCGCGAAAAGATTCTCGAGGAAAAAGAAATGGCGGAATGGCCAACAAATAAGAGGCCATAA |
| Reference |
(1) Cunha LD et al. (2015). Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA. Nat Commun. 6:10205. [PudMed:26687278] 
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| (2) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632] |
(3) Carey KL; Newton HJ; Luhrmann A; Roy CR (2011). The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication. PLoS Pathog. 7(5):e1002056. [PudMed:21637816] 
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(4) Chen C; Banga S; Mertens K; Weber MM; Gorbaslieva I; Tan Y; Luo ZQ; Samuel JE (2010). Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii. Proc Natl Acad Sci U S A. 107(50):21755-60. [PudMed:21098666]
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(5) Zusman T; Aloni G; Halperin E; Kotzer H; Degtyar E; Feldman M; Segal G (2007). The response regulator PmrA is a major regulator of the icm/dot type IV secretion system in Legionella pneumophila and Coxiella burnetii. Mol Microbiol. 63(5):1508-23. [PudMed:17302824]
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| experimental literature |
| in silico analysis literature |