SecReT4
T4SS ID157
StrainCoxiella burnetii RSA 493
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_002971
Location1559342..1591749
NameDot/Icm
Functioneffector translocation
ClassificationType IVB; Type I
experimental Experimental investigation has been performed on this T4SS.

T4SS components
ComponentDotADotBDotCDotDIcmBIcmCIcmDIcmEIcmF
Number111111110
ComponentIcmGIcmHIcmJIcmKIcmLIcmMIcmNIcmOIcmP
Number101120111
ComponentIcmQIcmRIcmSIcmTIcmVIcmWIcmXLvgA
Number10111110

The information of T4SS components from NC_002971
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1CBU_16121555602..1555697 [-], 9629654902hypothetical protein 
2CBU_16131555801..1555956 [-], 15629654903hypothetical protein 
3CBU_16141555989..1556408 [-], 42029654904hypothetical protein 
4CBU_16181558036..1558389 [+], 35429654908hypothetical protein 
5CBU_16211559190..1559327 [+], 13829654911hypothetical protein 
6CBU_1622 (icmB)1559342..1562353 [-], 301229654912IcmB  IcmB
7CBU_1623 (icmJ)1562426..1563064 [-], 63929654913IcmJ  IcmJ
8CBU_1624 (icmD)1563077..1563493 [-], 41729654914hypothetical protein  IcmD
9CBU_1625 (icmC)1563587..1564096 [-], 51029654915hypothetical protein  IcmC
10CBU_1626 (icmG)1564167..1564901 [-], 73529654916hypothetical protein  IcmG
11CBU_1627 (icmE)1564919..1568038 [-], 3120215919214IcmE  IcmE
12CBU_1628 (icmK)1568025..1569080 [-], 1056215919215IcmK  IcmK
13CBU_1629 (icmL.1)1569091..1569747 [-], 65729654919IcmL  IcmL
14CBU_1630 (icmL.2)1569749..1570372 [-], 62429654920IcmL  IcmL
15CBU_1631 (icmN)1570379..1571017 [-], 639215919216ompA family protein  IcmN
16CBU_1632 (icmO)1571027..1573405 [-], 237929654922IcmO  IcmO
17CBU_1633 (icmP)1573381..1574544 [-], 116429654923IcmP  IcmP
18CBU_1634 (icmQ)1574545..1575261 [-], 71729654924hypothetical protein  IcmQ
19CBU_1634a1575258..1575407 [-], 150215919217hypothetical protein 
20CBU_16351575523..1575696 [+], 17429654925hypothetical protein 
21CBU_16361576035..1577210 [-], 117629654926hypothetical protein 
22CBU_16381577295..1578500 [-], 120629654928ATPase 
23CBU_16391578612..1579808 [-], 119729654929hypothetical protein 
24CBU_1639c1580306..1581400 [-], 1095215919218transposase 
25CBU_1641 (icmT)1581517..1581774 [+], 25829654931IcmT protein  IcmT
26CBU_1642 (icmS)1581774..1582112 [+], 33929654932IcmS protein  IcmSaccesspry protein
27CBU_1643 (dotD)1582269..1582778 [+], 510215919219DotD  DotD
28CBU_1644 (dotC)1582781..1583605 [+], 82529654934DotC  DotC
29CBU_1645 (dotB)1583643..1584761 [+], 111929654935Dot/Icm secretion system ATPase DotB  DotB
30CBU_16461584768..1586102 [+], 133529654936transporter 
31CBU_16471586424..1586519 [-], 9629654937hypothetical protein 
32CBU_1648 (dotaA)1586574..1589018 [-], 2445215919220DotA protein  DotA
33CBU_1649 (icmV)1589015..1589509 [-], 495215919221hypothetical protein  IcmV
34CBU_1650 (icmW)1589699..1590148 [+], 45029654940IcmW  IcmW
35CBU_16511590145..1590603 [+], 45929654941hypothetical protein 
36CBU_1652 (icmX)1590619..1591749 [+], 113129654942IcmX  IcmX
37CBU_1653a1592465..1592647 [+], 183215919222virulence-associated protein C 
38CBU_1655 (rfaE)1592672..1594162 [-], 1491215919223bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 
39CBU_16561594170..1594271 [-], 10229654946hypothetical protein 
40CBU_16571594438..1595202 [-], 76529654947alpha-L-glycero-D-manno-heptose beta-1,4-glucosyltransferase 
41CBU_16581595243..1596328 [-], 108629654948hypothetical protein 
 
accesspry protein This T4SS contains information of accessory protein.
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

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Proteins        Genes

Effectors
cpeA, cpeB, cpeC, cpeE, CBUA0020, cpeF, cpeG, cpeH, CBU_0014, CvpB（Coxiella vacuolar protein B）/cig2, cirA, CBU_0062, AnkA, MceA, CBU_0113, CBU_0122, coxK1, AnkC, CBU_0270, CBU_0295, CBU_0372, cetCb2, CBU_0407, coxCC3, cirB, AnkF, CBU_0469, CBU_0513, CBU_0534, CBU_0590, cetCb3, CBU_0635, CBU_0637, CvpA（Coxiella vacuolar protein A）, CBU_0773, AnkG, coxCC4, CBU_0801, coxCC5, cem3, CBU_1063, CBU_1079, CBU_1198, AnkI, AnkI, CBU_1217, AnkI, OmpA, CBU_1370, CBU_1387, coxDFb4, CBU_1434, coxTPR1, cig44, CBU_1530, cig49, CvpC（Coxiella vacuolar protein C）, CBU_1566, coxCC12, CBU_1576, CBU_1594, CBU_1607, CBU_1614, CBU_1636, CBU_1639, CBU_1665, CBU_1676, CBU_1677, CBU_1685, cetCb5, cetCb6, cig57, CBU_1752, CBU_1754, AnkM, coxH3, CBU_1789, CBU_1790, CvpD（Coxiella vacuolar protein D）, CBU_1819, IcaA, CBU_1824, coxDFB6, CvpE（Coxiella vacuolar protein E）, CBU_2007, CBU_2013, CBU_2028, CBU_2052, CBU_2061, CBU_2076, coxFIC1, CBU_0006, CBU_0040, CBU_0183, CBU_0294, CBU_0384, CBU_0523, CBU_0554, CBU_0885, cirC, AnkH, CBU_1045a, CBU_1076, CBU_1090, CBU_1186, CBU_1217a, CBU_1270, coxCC6, CBU_1349, coxK2, CBU_1409, CBU_1493, CBU_1570b, CBU_1590b, CBU_1634a, CBU_1639c, CBU_1699a, CBU_1716a, CBU_1758a, CBU_1785, CBU_1794, CBU_1896a, CBU_1959b, CBU_1987b, CBU_2016, CBU_2056, CBUA0015

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1CBUA0006 2546..3571 [+], 102629648119hypothetical proteinexperimental  cpeA
2CBUA0013 14418..15149 [+], 73229648125hypothetical proteinexperimental  cpeB
3CBUA0014 15536..15769 [+], 23429648126hypothetical proteinexperimental  cpeC
4CBUA0016 16686..17711 [+], 102629648128CbhE proteinexperimental  cpeE
5CBUA0020 19736..20587 [-], 85229648132hypothetical proteinexperimental  CBUA0020
6CBUA0023 22568..23269 [-], 70229648135hypothetical proteinexperimental  cpeF
7CBUA0025 24282..24542 [-], 26129648137hypothetical proteinexperimental  cpeG
8CBUA0034 30413..30619 [-], 20729648145hypothetical proteinexperimental  cpeH
9CBU_0014 13226..14479 [-], 125429653378low-affinity inorganic phosphate transporterexperimental  CBU_0014
10CBU_0021 18337..20766 [+], 243029653385hypothetical proteinexperimental  CvpB（Coxiella vacuolar protein B）/cig2interaction
11CBU_0041 38088..40220 [-], 213329653404hypothetical proteinexperimental  cirAinteraction
12CBU_0062 55870..57375 [+], 150629653423DnaJ domain-containing proteinexperimental  CBU_0062
13CBU_0072 65611..66810 [+], 120029653433ankyrin repeat-containing proteinexperimental  AnkA
14CBU_0077 71573..72364 [+], 79229653438hypothetical proteinexperimental  MceAinteraction
15CBU_0113 105721..105933 [-], 21329653471hypothetical proteinexperimental  CBU_0113
16CBU_0122 111785..112063 [+], 27929653480hypothetical proteinexperimental  CBU_0122
17CBU_0175 156814..157554 [+], 74129653529serine/threonine kinaseexperimental  coxK1
18CBU_0201 189646..190041 [-], 39629653555ankyrin repeat-containing proteinexperimental  AnkC
19CBU_0270 241159..242379 [+], 122129653622trans-2-enoyl-CoA reductase  CBU_0270
20CBU_0295 261774..263243 [-], 147029653646hypothetical proteinexperimental  CBU_0295
21CBU_0372 335348..336712 [-], 136529653720Fic family proteinexperimental  CBU_0372
22CBU_0388 348584..352762 [+], 417929653735hypothetical proteinexperimental  cetCb2interaction
23CBU_0407 365200..365301 [-], 10229653754hypothetical protein  CBU_0407
24CBU_0410 366234..367970 [-], 173729653756hypothetical proteinexperimental  coxCC3
25CBU_0425 377351..378718 [-], 136829653771hypothetical proteinexperimental  cirB
26CBU_0447 393840..394394 [-], 55529653792ankyrin repeat-containing proteinexperimental  AnkF
27CBU_0469 411489..411692 [-], 20429653812hypothetical proteinexperimental  CBU_0469
28CBU_0513 453557..454705 [+], 114929653853fructose-1,6-bisphosphataseexperimental  CBU_0513
29CBU_0534 478846..480042 [-], 119729653874hypothetical proteinexperimental  CBU_0534
30CBU_0590 540871..541044 [+], 17429653928hypothetical proteinexperimental  CBU_0590
31CBU_0626 569797..571884 [+], 208829653964hypothetical proteinexperimental  cetCb3
32CBU_0635 583288..584778 [+], 149129653973hypothetical proteinexperimental  CBU_0635
33CBU_0637 585733..586494 [-], 76229653975coenzyme PQQ synthesis protein Cexperimental  CBU_0637
34CBU_0665 607018..608004 [+], 98729654003hypothetical proteinexperimental  CvpA（Coxiella vacuolar protein A）interaction
35CBU_0773 (phnB)718037..718507 [+], 47129654103glyoxalaseexperimental  CBU_0773
36CBU_0781 722881..723897 [+], 101729654110ankyrin repeat-containing proteinexperimental  AnkGinteraction
37CBU_0794 742864..744258 [-], 139529654122hypothetical proteinexperimental  coxCC4
38CBU_0801 (rimI)748750..749187 [+], 43829654129ribosomal-protein-S18-alanine acetyltransferaseexperimental  CBU_0801
39CBU_0881 833049..833714 [-], 66629654207hypothetical proteinexperimental  coxCC5
40CBU_0978 930350..930817 [+], 46829654294hypothetical proteinexperimental  cem3
41CBU_1063 1007671..1009077 [+], 140729654371hypothetical proteinexperimental  CBU_1063
42CBU_1079 1023599..1024195 [-], 59729654386hypothetical proteinexperimental  CBU_1079
43CBU_1198 1142253..1142789 [+], 53729654501hypothetical proteinexperimental  CBU_1198
44CBU_1213 1157067..1159040 [+], 197429654516ankyrin repeat-containing proteinexperimental  AnkI
45CBU_1214 1159107..1159244 [+], 13829654517hypothetical protein  AnkI
46CBU_1217 1161602..1163095 [+], 149429654520hypothetical proteinexperimental  CBU_1217
47CBU_1221 1166639..1167232 [-], 59429654524lipoprotein  AnkI
48CBU_1260 1210764..1211510 [+], 74729654562OmpA-like transmembrane domain-containing proteinexperimental  OmpA
49CBU_1370 1319489..1320475 [-], 98729654667hypothetical proteinexperimental  CBU_1370
50CBU_1387 1337068..1337718 [+], 65129654684hypothetical proteinexperimental  CBU_1387
51CBU_1425 1372939..1373391 [-], 45329654717hypothetical proteinexperimental  coxDFb4
52CBU_1434 1386207..1386668 [-], 46229654725hypothetical proteinexperimental  CBU_1434
53CBU_1457 1409997..1412027 [-], 203129654748hypothetical proteinexperimental  coxTPR1
54CBU_1460 1414164..1414949 [-], 78629654751hypothetical proteinexperimental  cig44
55CBU_1530 1479184..1481121 [-], 193829654821hypothetical proteinexperimental  CBU_1530
56CBU_1543 1491599..1492165 [-], 56729654834hypothetical proteinexperimental  cig49
57CBU_1556 1505256..1506959 [+], 170429654847hypothetical proteinexperimental  CvpC（Coxiella vacuolar protein C）
58CBU_1566 1514039..1514773 [+], 73529654857hypothetical proteinexperimental  CBU_1566
59CBU_1569 1516105..1517748 [+], 164429654860hypothetical proteinexperimental  coxCC12
60CBU_1576 1523065..1525584 [+], 252029654867hypothetical proteinexperimental  CBU_1576
61CBU_1594 1538945..1539394 [+], 45029654885GatB/Yqey domain-containing proteinexperimental  CBU_1594
62CBU_1607 1552010..1552408 [-], 39929654897hypothetical proteinexperimental  CBU_1607
63CBU_1614 1555989..1556408 [-], 42029654904hypothetical proteinexperimental  CBU_1614
64CBU_1636 1576035..1577210 [-], 117629654926hypothetical proteinexperimental  CBU_1636
65CBU_1639 1578612..1579808 [-], 119729654929hypothetical proteinexperimental  CBU_1639
66CBU_1665 1600647..1602386 [-], 174029654955hypothetical proteinexperimental  CBU_1665
67CBU_1676 1609953..1611038 [-], 108629654966hypothetical proteinexperimental  CBU_1676interaction
68CBU_1677 1611108..1611542 [-], 43529654967hemerythrin HHE cation binding domain proteinexperimental  CBU_1677
69CBU_1685 1616280..1617701 [+], 142229654975hypothetical proteinexperimental  CBU_1685
70CBU_1686 1617723..1620044 [+], 232229654976hypothetical proteinexperimental  cetCb5
71CBU_1724 1656991..1659234 [-], 224429655013hypothetical proteinexperimental  cetCb6
72CBU_1751 1681753..1683015 [+], 126329655039hypothetical proteinexperimental  cig57interaction
73CBU_1752 1683051..1684289 [+], 123929655040hypothetical proteinexperimental  CBU_1752
74CBU_1754 1684801..1685397 [-], 59729655042hypothetical proteinexperimental  CBU_1754
75CBU_1755 1685407..1685532 [-], 12629655043hypothetical protein  AnkM
76CBU_1769 1700146..1700763 [-], 61829655057alpha/beta hydrolaseexperimental  coxH3
77CBU_1789 1721182..1722048 [-], 86729655077SMP-30/CGR1 family proteinexperimental  CBU_1789
78CBU_1790 1722228..1724132 [+], 190529655078hypothetical proteinexperimental  CBU_1790
79CBU_1818 1748815..1750260 [+], 144629655105hypothetical proteinexperimental  CvpD（Coxiella vacuolar protein D）
80CBU_1819 1750313..1751446 [+], 113429655106hypothetical proteinexperimental  CBU_1819
81CBU_1823 1753253..1754302 [+], 105029655110hypothetical proteinexperimental  IcaAinteraction
82CBU_1824 1754311..1754541 [-], 23129655111hypothetical protein  CBU_1824
83CBU_1825 1754604..1754951 [+], 34829655112hypothetical proteinexperimental  coxDFB6
84CBU_1863 1791559..1793370 [-], 181229655148hypothetical proteinexperimental  CvpE（Coxiella vacuolar protein E）
85CBU_2007 1912769..1913956 [-], 118829655290hypothetical proteinexperimental  CBU_2007
86CBU_2013 1919703..1920800 [-], 109829655296hypothetical proteinexperimental  CBU_2013
87CBU_2028 1935267..1936013 [-], 74729655309hypothetical proteinexperimental  CBU_2028
88CBU_2052 1957881..1958783 [-], 90329655331hypothetical proteinexperimental  CBU_2052
89CBU_2061 1967569..1967706 [-], 13829655340hypothetical protein  CBU_2061
90CBU_2076 1978262..1978579 [+], 31829655354hypothetical proteinexperimental  CBU_2076
91CBU_2078 1979521..1980567 [-], 104729655356Fic family proteinexperimental  coxFIC1
92CBU_0006 6684..7778 [+], 1095215918860IS1111A transposase  CBU_0006
93CBU_0040 36620..37714 [+], 1095215918869IS1111A transposase  CBU_0040
94CBU_0183 172242..172514 [+], 273215918909hypothetical proteinexperimental  CBU_0183
95CBU_0294 260362..261777 [+], 1416215918930phosphoglucomutase  CBU_0294
96CBU_0384 345003..346097 [+], 1095215918954IS1111A transposase  CBU_0384
97CBU_0523 465851..466945 [-], 1095215918986IS1111A transposase  CBU_0523
98CBU_0554 502093..503187 [+], 1095215918997IS1111A transposase  CBU_0554
99CBU_0885 837344..838510 [+], 1167215919063hypothetical proteinexperimental  CBU_0885interaction
100CBU_0937 886730..888181 [+], 1452215919069hypothetical proteinexperimental  cirC
101CBU_1023a 967315..967593 [+], 279215919087hypothetical protein  AnkH
102CBU_1045a 988083..988196 [-], 114215919091hypothetical proteinexperimental  CBU_1045a
103CBU_1076 1021147..1022241 [-], 1095215919098IS1111A transposase  CBU_1076
104CBU_1090 1034651..1035745 [+], 1095215919102IS1111A transposase  CBU_1090
105CBU_1186 1128693..1129787 [+], 1095215919124IS1111A transposase  CBU_1186
106CBU_1217a 1163350..1164444 [+], 1095215919135transposase  CBU_1217a
107CBU_1270 1220091..1221185 [-], 1095215919149IS1111A transposase  CBU_1270
108CBU_1314 1264046..1264690 [-], 645215919158hypothetical proteinexperimental  coxCC6
109CBU_1349 1298083..1299822 [+], 1740215919168hypothetical proteinexperimental  CBU_1349
110CBU_1379a 1330216..1331064 [+], 849215919171hypothetical proteinexperimental  coxK2
111CBU_1409 1359670..1360506 [+], 837215919178hypothetical protein  CBU_1409
112CBU_1493 1445840..1447513 [+], 1674215919197hypothetical proteinexperimental  CBU_1493
113CBU_1570b 1519268..1520362 [-], 1095215919209transposase  CBU_1570b
114CBU_1590b 1537463..1538557 [-], 1095215919211transposase  CBU_1590b
115CBU_1634a 1575258..1575407 [-], 150215919217hypothetical proteinexperimental  CBU_1634a
116CBU_1639c 1580306..1581400 [-], 1095215919218transposase  CBU_1639c
117CBU_1699a 1633010..1634104 [+], 1095215919230transposase  CBU_1699a
118CBU_1716a 1646136..1647230 [+], 1095215919233transposase  CBU_1716a
119CBU_1758a 1689450..1690514 [+], 1065215919246transposase  CBU_1758a
120CBU_1785 1715696..1716790 [+], 1095215919256IS1111A transposase  CBU_1785
121CBU_1794 1725445..1726263 [+], 819215919260hypothetical proteinexperimental  CBU_1794
122CBU_1896a 1819165..1820259 [+], 1095215919285transposase  CBU_1896a
123CBU_1959b 1876234..1877328 [-], 1095215919305transposase  CBU_1959b
124CBU_1987b 1898514..1899608 [+], 1095215919312transposase  CBU_1987b
125CBU_2016 1923186..1923782 [+], 597215919321hypothetical proteinexperimental  CBU_2016
126CBU_2056 1962085..1962747 [-], 663215919329hypothetical proteinexperimental  CBU_2056
experimental T4SE derived from experimental literature.
interaction This effector contains information of interaction.

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Proteins        Genes
The information on requirements for T4SS substrate-channel docking

Certain T4SS substrates require secretion chaperones for translocation. These chaperones often possess physical properties (small size of 15 kDa, acidic pI, and amphipathic helices) resembling those of chaperones associated with the type III secretion systems, a family of macromolecular translocation systems ancestrally related to bacterial flagella.

#Accessory protein(GI)motif(s)Substrate(s)FunctionReference
1IcmS (chaperone) (29654932)NDAnkB, AnkH, AnkI, AnkJ, AnkMThe chaperone IcmS is essential for translocation into the host cytosol.(1) PubMed: 19411324
Tips:
1.Substrate(s): For the conjugation systems, the listed proteins are relaxases that bind a cognate T4CP and are delivered to recipient cells. For the effector translocator systems, the listed proteins are effectors that play a role in the infection processes of the bacterial pathogen.
2.motif(s):The motifs listed are required for substrate translocation. In some cases, the protein or its C-terminal fragment (CT) is sufficient to mediate translocation to target cells, as shown by fusion to a reporter protein such as Cre recombinase or adenylate cyclase. Amino acids (aa) at positions listed relative to the C-terminal fragment (subscript) are required for translocation, as shown by mutational analysis. ND, not determined. Parentheses indicate that the interaction between a protein substrate and a cognate T4CP has been experimentally shown.
3.Accessory protein: Accessory factors required for T4SS channel docking or translocation. The proposed function in mediating substrate-T4SS channel docking is shown in parentheses.PubMed:19946141

(1) Voth DE; Howe D; Beare PA; Vogel JP; Unsworth N; Samuel JE; Heinzen RA (2009). The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion. J Bacteriol. 191(13):4232-42. [PudMed:19411324] experimental
The information on host-pathogen interaction.

#Name(Protein GI)Host site/SubstrateSourceFunctionReference
1AnkG (29654110)gC1qR (p32)human, murineAnkG interacts with gC1qR(p32) to regulate an anti-apoptotic pathway which is required for adaptation to mammalian hosts of Coxiella.(1) PubMed: 20944063experimental
2CBU_0885 (215919063)unknownunknownCBU_0885 can modulate MAP kinase pathway.(2) PubMed: 24958706experimental
3CBU_1676 (29654966)unknownunknownCBU_1676 can modulate MAP kinase pathway.(3) PubMed: 24958706experimental
4CetCb2 (29653735)unknownunknownCetCb2 can modulate MAP kinase pathway.(4) PubMed: 24958706experimental
5Cig57 (29655039)FCHO2humanCig57 interacts with FCHO2, an accessory protein of clathrin coated pits,to co-opts trafficking which mediated by clathrin and to promote the biogenesis of the fusogenic Coxiella replicative vacuole .(5) PubMed: 28002452experimental
6CirA (29653404)Ras homolog gene family, member A (RhoA)human, murineCirA interacts with RhoA on the Coxiella-containing vacuole (CCV) to stimulate GTPase aactivity of RhoA.(6) PubMed: 27324482experimental
7CvpA (29654003)AP2 adaptor complexhumanCvpA may recruit host cell clathrin transport machinery and other factors to the CCV to contribute to biogenesis of Coxiella-containing vacuole (CCV) by interacting with the AP2 adaptor complex.(7) PubMed: 24248335experimental
8CvpB/Cig2 (29653385)unknownunknownCig2 facilitates constitutive fusion of autophagosomes with the Coxiella-containing vacuole (CCV) to keep this region in an autolysosomal stage of maturation. This process may lead to CCV homotypic fusion and decrease host tolerance to increase the virulence of the bacteria.(8) PubMed: 27435465experimental
9CvpB/Cig2 (29653385)PI(3)P and phosphatidylserine (PS)humanCvpB/cig2 interact with PI(3)P and PS on early endosomal compartments and Coxiella-containing vacuoles (CCVs) to disturb the activity of the phosphatidylinositol 5-kinase PIKfyve. Then it manipulates PI(3)P metabolism.(9) PubMed: 27226300experimental
10IcaA (29655110)caspase-11murineIcaA inhibited the caspase-11 activation in macrophages.(10) PubMed: 26687278experimental
11MceA (29653438)MitochondrionhumanMceA is integrated into the mitochondrial outer membrane specifically to form a complex. (11) PubMed: 28242621experimental
experimental This T4SE is mentioned in the literature.

(1) Luhrmann A; Nogueira CV; Carey KL; Roy CR (2010). Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proc Natl Acad Sci U S A. 107(44):18997-9001. [PudMed:20944063] experimental
(2) Lifshitz Z et al. (2014). Identification of novel Coxiella burnetii Icm/Dot effectors and genetic analysis of their involvement in modulating a mitogen-activated protein kinase pathway. Infect Immun. 82(9):3740-52. [PudMed:24958706] experimental in_silico
(3) Lifshitz Z et al. (2014). Identification of novel Coxiella burnetii Icm/Dot effectors and genetic analysis of their involvement in modulating a mitogen-activated protein kinase pathway. Infect Immun. 82(9):3740-52. [PudMed:24958706] experimental in_silico
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experimental This literature contains experimental investigation
in_silico This literature contains bioinformatics investigation

Genomics & Bioinformatics Group in MML, SJTU