| Effector Protein ID: 29655039 |
 T4SS name [ID] | Dot/Icm [157] |
| Gene symbol | - |
| Locus tag | CBU_1751 |
| Strain | Coxiella burnetii RSA 493 |
| Replicon | chromosome [GenBank: NC_002971] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1681753..1683015 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | cig57 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Cig57 is a significant virulence factor that co-opts clathrin-mediated trafficking, via interaction with FCHO2, to facilitate the biogenesis of the fusogenic Coxiella replicative vacuole and enable intracellular success of this human pathogen. |
| UniProt ID | Q83AX6 |
| KEGG ID | cbu:CBU_1751 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 420 a.a. [Download] |
| >gi|29655039|ref|NP_820731.1| hypothetical protein CBU_1751 [Coxiella burnetii RSA 493] MGRVFSYIQRKRDIQEKDHQDRQVDPENYLGQKLQQAREEVAALEKKIPNRLQELEREISALKTSIDSDV LKAPPRERQKILIEKKTSTMLTSAAREQWEAQEERLPKLALLEAEQRALTAHHDQFTNENSELNITCRAL DNVEAEFNDRQTNRRNIQSLIAEADPHLRVLDKTLMASRVKFEIEDLWMHLKRDEPHDLNNPLKPHLDEP YRLPLLEKDSGNINQLTKAVNNDLKELQELYKTAQLTLEGSKFEAYLKEEWKKLHDKLKRDSFALLKEMR SRVNIVGERPNAVPLMEKVTNICQFFNSGVKSKVTLLSKTTDTFACCHVNKAGELTQLFGGMEPTRKEIQ QALEQFDRKVAIKSYRKFWLFGSKRFCLDFADAGDKERFCQILEGILQKRKEETVPEEVSTSIATRPARP |
| - |
| Nucleotide Sequence: 1263 bp [Download] |
| >gi|77358712|ref|NC_002971.3|:1681753-1683015 Coxiella burnetii RSA 493 chromosome, complete genome ATGGGTAGAGTTTTTTCGTACATTCAAAGGAAACGCGATATCCAGGAAAAGGATCATCAGGATCGTCAAG TCGATCCGGAAAACTATCTTGGGCAAAAGCTGCAACAAGCTCGAGAGGAAGTAGCCGCGTTAGAAAAGAA AATACCGAACCGTCTTCAGGAACTTGAGAGAGAGATTTCTGCCCTTAAAACTTCCATCGACTCAGATGTG CTAAAAGCCCCCCCCCGCGAACGACAAAAGATATTAATAGAGAAAAAAACTTCAACCATGTTAACAAGTG CGGCCCGGGAGCAGTGGGAAGCTCAAGAGGAACGGCTACCGAAACTGGCTCTCTTAGAAGCAGAGCAACG AGCGCTCACCGCACACCACGACCAGTTCACCAACGAAAATAGCGAACTCAACATTACTTGCCGCGCATTA GACAATGTAGAAGCCGAATTCAACGATAGGCAAACTAACAGGAGGAATATTCAAAGCCTTATTGCTGAAG CTGACCCCCATCTGCGCGTCCTTGACAAAACTCTAATGGCATCAAGAGTAAAATTCGAGATTGAAGACCT TTGGATGCATCTAAAACGTGACGAGCCACATGATTTAAATAATCCTCTCAAACCTCATTTAGATGAACCT TATCGGCTACCCCTCTTAGAAAAAGACAGTGGCAACATTAACCAGCTAACTAAAGCTGTTAATAACGACT TAAAAGAACTTCAGGAGTTATATAAAACCGCTCAACTCACTTTGGAGGGATCGAAATTTGAGGCCTACCT TAAAGAGGAATGGAAAAAACTCCATGATAAACTGAAAAGAGATTCATTTGCACTTTTAAAGGAAATGCGA TCGCGCGTGAACATCGTAGGGGAAAGGCCCAATGCCGTCCCTTTAATGGAAAAAGTCACAAATATTTGCC AATTTTTTAACAGCGGAGTGAAATCGAAAGTAACTCTCCTTAGCAAAACTACCGATACCTTTGCCTGCTG CCATGTTAATAAAGCAGGCGAGCTGACCCAGCTATTTGGTGGCATGGAACCAACTCGAAAAGAAATTCAG CAAGCACTCGAGCAGTTTGACCGGAAGGTTGCAATTAAGTCTTACCGCAAATTCTGGCTTTTTGGCTCGA AGAGATTCTGTCTCGACTTCGCAGACGCGGGGGACAAAGAAAGATTCTGTCAAATCCTAGAGGGAATCCT CCAAAAAAGAAAGGAGGAGACAGTACCAGAAGAAGTGTCTACGTCGATTGCGACCCGACCCGCAAGGCCT TAA |
| Reference |
(1) Latomanski EA et al. (2016). The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii. PLoS Pathog. 12(12):e1006101. [PudMed:28002452] 
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| (2) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632] |
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(3) Chen C; Banga S; Mertens K; Weber MM; Gorbaslieva I; Tan Y; Luo ZQ; Samuel JE (2010). Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii. Proc Natl Acad Sci U S A. 107(50):21755-60. [PudMed:21098666]
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| experimental literature |