| Effector Protein ID: 29654847 |
 T4SS name [ID] | Dot/Icm [157] |
| Gene symbol | - |
| Locus tag | CBU_1556 |
| Strain | Coxiella burnetii RSA 493 |
| Replicon | chromosome [GenBank: NC_002971] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1505256..1506959 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | CvpC（Coxiella vacuolar protein C） |
| T4CP requirement | T4CP Depedent |
| Target/Effection | CvpB, CvpC, CvpD and CvpE confer effector functions associated with PV bio genesis. They are C. burnetii effectors that target components of the late endosomal system, and that CvpC also targets recycling endosomes. |
| UniProt ID | Q83BF4 |
| KEGG ID | cbu:CBU_1556 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 567 a.a. [Download] |
| >gi|29654847|ref|NP_820539.1| hypothetical protein CBU_1556 [Coxiella burnetii RSA 493] MPSDRNGDSGTLLPLPGLWPTETTPLIERHKAATILDHFYSFLRKLSLPASLIQSLFSNTFFIMEFFKLI ELDNPVIEGVAISMFALGTTGSFISTVSPHVTKERHSPHPRVNQFLSDCLYIFDFEIRLQEEVNQNQEIW FYFNDDQLKEDFKKEITDINELRETLKTLVDETYPNHTLAFITQDELEACNNDLPTQQRIYYWKKQPVNT NLTHVFIDIHSHMEGMLGGWPRAIIFRYLQAILPFMSGVLSVNHVLQHFIGGEEDMPLPRYIPMQVFAIA IALFKLSITWERKFKRGEKWWAEFYLRVKLGKSSICEILKICLTSPHNLLALCTYTASMFFFLEKGAIDQ ILKITCRISTACEHDFNALNPPPLSGCKLPVAYSLTAMSTITLIFTQIITDIDRYLQNQNAASGFCEKVT RLFQCLCRRDQNRETNPETLLEDLSSDSRQTTQKHFKVWVAVIAANTLEGCQQGLGIFTSMLSFLAHVTQ QSPNAVLKTVAAVFAAGASLSYWGWLHRQGKDFLTKTAETVNQIKDYLPLSIFSCPSSHDSHEPIVANEA PVNYAPV |
| - |
| Nucleotide Sequence: 1704 bp [Download] |
| >gi|77358712|ref|NC_002971.3|:1505256-1506959 Coxiella burnetii RSA 493 chromosome, complete genome ATGCCTTCTGATAGAAACGGCGATTCAGGAACTTTATTGCCTCTCCCGGGATTGTGGCCTACTGAAACCA CTCCTCTCATCGAGCGTCATAAGGCTGCTACCATTCTGGATCACTTTTACAGTTTTTTAAGGAAACTATC CCTTCCCGCTTCTTTGATCCAATCGCTTTTTAGTAACACATTTTTCATTATGGAATTTTTTAAATTAATT GAATTAGACAATCCGGTTATTGAAGGTGTTGCCATTTCAATGTTCGCGCTCGGTACAACAGGTTCTTTTA TTTCAACCGTATCTCCCCACGTCACGAAGGAAAGGCACAGTCCCCACCCAAGAGTTAACCAATTTCTTAG TGATTGCCTCTATATTTTTGACTTTGAAATTAGATTGCAAGAGGAAGTTAACCAAAACCAAGAAATTTGG TTTTATTTTAATGATGATCAATTAAAAGAAGATTTTAAAAAAGAAATCACTGACATTAATGAGTTGCGTG AAACTTTAAAAACCCTTGTTGATGAAACATACCCGAACCACACGCTTGCGTTTATAACTCAAGATGAGTT AGAGGCTTGTAATAATGATCTTCCAACGCAACAACGAATCTATTATTGGAAAAAACAACCCGTAAATACA AATCTCACTCATGTGTTCATCGACATTCATTCCCACATGGAGGGTATGCTCGGGGGGTGGCCAAGGGCAA TAATTTTCAGATACCTGCAAGCTATTCTACCTTTTATGAGCGGCGTTTTATCGGTGAATCACGTTCTGCA GCACTTTATTGGCGGGGAAGAAGACATGCCCTTACCTCGTTATATTCCTATGCAGGTTTTCGCCATCGCC ATCGCTCTTTTTAAACTCTCAATTACCTGGGAACGTAAATTTAAAAGGGGAGAAAAATGGTGGGCGGAAT TTTATTTGCGAGTAAAGCTGGGAAAATCCTCGATTTGTGAAATATTAAAGATCTGCTTGACAAGTCCGCA TAATTTGCTGGCGCTTTGTACTTACACCGCTTCTATGTTTTTCTTTTTGGAAAAAGGCGCTATCGACCAA ATATTAAAAATAACCTGCCGAATTTCAACGGCCTGTGAACATGACTTTAATGCACTCAACCCTCCCCCTT TAAGTGGATGTAAACTGCCGGTGGCTTACTCTCTAACCGCTATGTCCACAATCACGCTAATCTTCACGCA AATAATCACGGACATCGATCGTTATTTACAAAACCAAAATGCAGCCAGCGGATTTTGCGAAAAGGTCACT CGTCTTTTCCAATGCCTATGTAGACGAGATCAAAATCGAGAAACTAACCCCGAAACCCTCCTGGAGGACC TCTCATCAGACTCAAGGCAGACTACTCAGAAACATTTCAAGGTCTGGGTAGCTGTTATTGCTGCCAATAC GCTCGAAGGTTGCCAACAGGGGCTCGGTATTTTTACTTCCATGTTATCTTTTCTCGCGCACGTCACTCAG CAGAGTCCTAACGCCGTCCTTAAAACCGTTGCAGCCGTTTTTGCCGCCGGAGCCAGTTTGAGCTATTGGG GGTGGCTTCACAGGCAAGGTAAAGACTTTCTCACTAAAACGGCAGAGACTGTCAACCAAATTAAGGACTA TTTACCTCTTTCTATTTTCTCGTGTCCTTCCTCTCACGACTCCCATGAACCGATCGTCGCTAATGAAGCG CCGGTTAATTATGCTCCCGTTTAG |
| Reference |
(1) Larson CL et al. (2015). Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication. Infect Immun. 83(2):661-70. [PudMed:25422265]  
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| (2) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632] |
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(3) Chen C; Banga S; Mertens K; Weber MM; Gorbaslieva I; Tan Y; Luo ZQ; Samuel JE (2010). Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii. Proc Natl Acad Sci U S A. 107(50):21755-60. [PudMed:21098666]
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| experimental literature |
| in silico analysis literature |