| Effector Protein ID: 29654562 |
 T4SS name [ID] | Dot/Icm [157] |
| Gene symbol | - |
| Locus tag | CBU_1260 |
| Strain | Coxiella burnetii RSA 493 |
| Replicon | chromosome [GenBank: NC_002971] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1210956..1211702 [+] |
| Product | OmpA-like transmembrane domain-containing protein |
| Effector type | Protein |
| Descripton | OmpA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | OmpA is the first Coxiella invasin. Mutations in ompA strongly decreased Coxiella internalization and replication within host cells; OmpA-coated beads adhered to and were internalized by non-phagocytic cells and the ectopic expression of OmpA in E. coli triggered its internalization within cells. |
| UniProt ID | Q83C69 |
| KEGG ID | cbu:CBU_1260 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | OMP_b-brl [PF13505], Evalue: 4.5e-13, Aligned region: 6-248 OmpA_membrane [PF01389], Evalue: 3.0e-11, Aligned region: 35-248 |
| Protein Sequence: 248 a.a. [Download] |
| >gi|29654562|ref|NP_820254.1| OmpA-like transmembrane domain-containing protein [Coxiella burnetii RSA 493] MLKKIVIGVTATAAFGIGAGALAGGSVDQSYNNTSGAGFYVRGEAGYGLVDKKSGTSKVNFTGVTLTENS HTNTKKSRGFNGRVAIGYAFNPYFSLESGFTYYHPAYRDVNIAGSALPLFSSVQAEGRQKINLYSIDLMG KATLPIDNFYAFIEGGVAYVHTKFVAFTETGTAVSPLLPPVTSSVAVKVPSSSKGYIRPKAGIGVGYNIT QNIGVDVSYSRVFGQGKINNTNYLPNLNAVTLGLTYKF |
| - |
| Nucleotide Sequence: 747 bp [Download] |
| >gi|77358712|ref|NC_002971.3|:1210764-1211510 Coxiella burnetii RSA 493 chromosome, complete genome ATGTTGAAAAAAATTGTAATTGGCGTGACAGCCACTGCTGCTTTTGGTATTGGCGCCGGCGCATTAGCGG GCGGATCGGTTGATCAATCATATAATAATACCAGTGGTGCTGGTTTTTATGTTCGTGGTGAAGCAGGTTA TGGGTTGGTCGATAAAAAATCGGGCACTTCTAAAGTCAATTTCACTGGCGTAACGCTAACCGAAAACTCC CACACTAATACCAAAAAAAGCCGAGGCTTTAACGGTCGAGTTGCCATTGGTTATGCTTTCAATCCTTACT TCTCATTAGAATCAGGGTTTACTTACTACCACCCTGCTTACCGAGATGTAAACATAGCGGGAAGTGCGTT GCCTCTTTTCTCTTCCGTACAAGCCGAAGGCAGACAAAAAATAAACTTGTACTCTATTGATTTAATGGGC AAAGCGACCTTACCTATCGATAACTTCTATGCTTTTATCGAGGGTGGTGTTGCTTATGTGCATACTAAGT TTGTCGCGTTTACAGAAACGGGTACCGCGGTTAGTCCTCTCCTCCCTCCCGTAACTAGTTCTGTGGCTGT TAAGGTTCCGTCAAGCTCCAAAGGCTATATTCGACCGAAAGCCGGCATCGGTGTGGGCTATAATATCACC CAGAACATTGGCGTTGATGTTTCCTACTCACGTGTCTTTGGTCAAGGGAAAATCAATAACACTAACTACT TGCCTAACTTGAACGCAGTTACGCTGGGCTTAACTTACAAGTTCTAA |
| Reference |
(1) Martinez E et al. (2014). Identification of OmpA, a Coxiella burnetii protein involved in host cell invasion, by multi-phenotypic high-content screening. PLoS Pathog. 10(3):e1004013. [PudMed:24651569] 
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| experimental literature |