| Effector Protein ID: 29654110 |
 T4SS name [ID] | Dot/Icm [157] |
| Gene symbol | - |
| Locus tag | CBU_0781 |
| Strain | Coxiella burnetii RSA 493 |
| Replicon | chromosome [GenBank: NC_002971] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 722881..723897 [+] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | AnkG |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Inhibits apoptosis |
| UniProt ID | Q83DF6 |
| KEGG ID | cbu:CBU_0781 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 7.4e-13, Aligned region: 54..155 Ank_4 [PF13637], Evalue: 1.4e-05, Aligned region: 94..146 |
| Protein Sequence: 338 a.a. [Download] |
| >gi|29654110|ref|NP_819802.1| ankyrin repeat-containing protein [Coxiella burnetii RSA 493] MSRRETPTSTISSTPTGTRTPRRRLSRKGHPVRRSPLIAKNSIFTVFDLSFEILINAVEENSLDIIKNYL RGDSFHQTAKWGLNVPPKTDFQGDTLLIKAAKKGKFLIAKALLEAGAYKEIVNKLGETALICAVRHFRVE TLDLLIQYHADVKIKYKGQNLLELTLEKYSEKTKNFTLRIVQSLVAAGVELWHSDGSQIMASDKEIDEII RNARNLQIIKKEKREAEERARTKKSKQITLQRIQRDLEYISKRLPFEENILTTPDFPQLFFEISKLVEII SDSQKENKEEFAEASISLIDALKNFGMILEKRDVPGEVKKEDTTLSRNNSLSCLSSPR |
| - |
| Nucleotide Sequence: 1017 bp [Download] |
| >gi|77358712|ref|NC_002971.3|:722881-723897 Coxiella burnetii RSA 493 chromosome, complete genome ATGAGTAGACGTGAGACTCCCACTAGCACAATATCCTCAACGCCGACAGGAACTCGAACGCCGAGAAGGA GATTGAGCCGAAAAGGACATCCTGTAAGAAGAAGCCCGTTAATAGCAAAGAATTCGATATTTACTGTATT CGATTTATCGTTTGAAATACTCATAAATGCTGTAGAAGAAAACAGCTTAGACATAATAAAAAACTACCTT CGCGGGGATTCTTTTCATCAGACGGCGAAATGGGGCCTCAACGTACCGCCAAAGACGGATTTCCAGGGTG ACACGCTCTTAATAAAAGCGGCCAAGAAAGGAAAGTTTCTTATTGCCAAAGCATTATTGGAGGCTGGCGC TTACAAAGAGATAGTCAATAAGCTAGGAGAAACTGCCTTAATTTGTGCGGTACGCCATTTTCGAGTAGAG ACGCTCGATTTATTAATTCAGTATCATGCTGATGTGAAAATCAAATATAAAGGACAGAACCTTTTAGAAC TGACTCTCGAGAAATATTCCGAAAAGACTAAAAATTTTACTTTGCGCATTGTCCAATCCTTAGTGGCTGC AGGTGTAGAACTTTGGCATTCTGATGGAAGTCAAATCATGGCTAGCGATAAGGAAATTGATGAAATAATT AGAAATGCCAGAAACCTTCAAATCATAAAAAAGGAGAAACGAGAGGCAGAAGAACGAGCTCGAACAAAAA AATCGAAACAAATAACCTTACAGCGTATACAGCGCGACCTTGAATACATCAGTAAACGTCTTCCTTTTGA AGAAAATATATTAACAACTCCTGATTTTCCTCAGCTTTTCTTCGAGATTTCTAAGTTGGTTGAAATTATT TCCGACTCTCAAAAAGAAAATAAAGAAGAATTCGCTGAAGCTTCTATTTCTCTGATAGATGCCTTAAAAA ACTTTGGTATGATCCTGGAAAAACGCGATGTTCCAGGAGAAGTGAAAAAAGAAGACACAACGCTGTCTAG AAACAACTCTCTCTCTTGTCTGTCTAGTCCTCGGTGA |
| Reference |
| (1) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632] |
(2) Luhrmann A; Nogueira CV; Carey KL; Roy CR (2010). Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proc Natl Acad Sci U S A. 107(44):18997-9001. [PudMed:20944063] 
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(3) Voth DE; Howe D; Beare PA; Vogel JP; Unsworth N; Samuel JE; Heinzen RA (2009). The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion. J Bacteriol. 191(13):4232-42. [PudMed:19411324]
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(4) Pan X; Luhrmann A; Satoh A; Laskowski-Arce MA; Roy CR (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 320(5883):1651-4. [PudMed:18566289] 
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| experimental literature |
| in silico analysis literature |