| Effector Protein ID: 29653792 |
 T4SS name [ID] | Dot/Icm [157] |
| Gene symbol | - |
| Locus tag | CBU_0447 |
| Strain | Coxiella burnetii RSA 493 |
| Replicon | chromosome [GenBank: NC_002971] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 393840..394394 [-] |
| Product | ankyrin repeat-containing protein |
| Effector type | Protein |
| Descripton | AnkF |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Inhibits apoptosis |
| UniProt ID | Q83E81 |
| KEGG ID | cbu:CBU_0447 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 1.2e-17, Aligned region: 17..95 Ank_5 [PF13857], Evalue: 5.7e-15, Aligned region: 71..94 Ank [PF00023], Evalue: 7.5e-15, Aligned region: 74..95 Ank_4 [PF13637], Evalue: 1e-12, Aligned region: 45..94 |
| Protein Sequence: 184 a.a. [Download] |
| >gi|29653792|ref|NP_819484.1| ankyrin repeat-containing protein [Coxiella burnetii RSA 493] MRQREINDEAMQRLFEACIYNAPGEMERILQRTDIDPNQKYEDKTPLEIASLEGYRDIVELLIEHPLVVD SREGYQALHFACERGHVEIAELLLGKVVQRRGRVASKLLANLLYTTCESGKLEIVKLLIEGYARDPFIAL ERTEYGIPLAIAAARNFQPIVDYFWEQGVPYLEEEKRNNRGFQR |
| - |
| Nucleotide Sequence: 555 bp [Download] |
| >gi|77358712|ref|NC_002971.3|:c394394-393840 Coxiella burnetii RSA 493 chromosome, complete genome ATGAGACAGCGTGAAATTAATGATGAAGCTATGCAGCGGCTATTTGAAGCTTGTATCTATAATGCCCCCG GTGAGATGGAAAGGATATTGCAAAGGACGGACATTGATCCCAATCAAAAATATGAAGATAAAACACCACT CGAAATCGCTTCCTTGGAAGGTTATCGAGATATTGTGGAACTTTTAATTGAACACCCTCTCGTAGTCGAC TCAAGAGAGGGGTATCAAGCACTCCATTTCGCTTGTGAGCGTGGTCACGTAGAGATAGCAGAACTTTTAT TGGGTAAGGTAGTACAGCGGCGTGGGCGAGTTGCTTCAAAGCTATTGGCCAACCTTCTATACACCACCTG CGAATCAGGAAAGCTTGAAATTGTAAAACTATTAATTGAGGGATACGCTAGAGATCCCTTTATTGCTTTA GAGCGGACCGAATACGGCATCCCTCTGGCCATTGCAGCCGCCCGCAACTTTCAACCTATCGTCGATTACT TTTGGGAACAAGGCGTACCTTATCTGGAAGAAGAAAAAAGAAATAATCGCGGCTTCCAGCGGTAG |
| Reference |
(1) Wallqvist A et al. (2017). Mechanisms of action of Coxiella burnetii effectors inferred from host-pathogen protein interactions. PLoS One. 12(11):e0188071. [PudMed:29176882]  
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| (2) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632] |
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(3) Voth DE; Howe D; Beare PA; Vogel JP; Unsworth N; Samuel JE; Heinzen RA (2009). The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion. J Bacteriol. 191(13):4232-42. [PudMed:19411324]
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(4) Pan X; Luhrmann A; Satoh A; Laskowski-Arce MA; Roy CR (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 320(5883):1651-4. [PudMed:18566289]
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| experimental literature |
| in silico analysis literature |