| Effector Protein ID: 29653438 |
 T4SS name [ID] | Dot/Icm [157] |
| Gene symbol | - |
| Locus tag | CBU_0077 |
| Strain | Coxiella burnetii RSA 493 |
| Replicon | chromosome [GenBank: NC_002971] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 71573..72364 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | MceA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | The Coxiella effector MceA specifically localizes to the outer membrane of mitochondria during infection, but when it is transfected into mammalian cells, MceA is associated with lysosomal membranes. |
| UniProt ID | Q83F71 |
| KEGG ID | cbu:CBU_0077 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 263 a.a. [Download] |
| >gi|29653438|ref|NP_819130.1| hypothetical protein CBU_0077 [Coxiella burnetii RSA 493] MRQLVSIKHKLYAPLKKIDLTAVPLMTVGAVLVFLLGKNKVISPFADDYIFTTDGNIKNEFAVYFALVGA NAALSIYTSARTIFNDWQLRKAHYANPENRLQEIGAQISEGTQLLTGPVELEENSNECKWEARPALGAFF EKHPLLWHGVSTLLRTTGVILISTATMSPPFLERVVDLIKDNLSFSMEEQTIFYGSYAAFEVLTLLLNWV NYHEMQMPLKLFLKEGENNARLRECKSALFSLLHNDQPVPEPNVEASRGCSIM |
| - |
| Nucleotide Sequence: 792 bp [Download] |
| >gi|77358712|ref|NC_002971.3|:71573-72364 Coxiella burnetii RSA 493 chromosome, complete genome ATGAGACAACTCGTTTCAATTAAACATAAGCTTTATGCTCCGTTGAAGAAAATAGATTTGACGGCTGTGC CGTTAATGACTGTTGGTGCGGTGCTTGTATTTTTATTAGGTAAAAATAAAGTGATTTCTCCTTTTGCAGA TGACTATATTTTTACGACCGATGGTAATATTAAAAATGAATTTGCTGTTTATTTTGCTTTAGTAGGGGCT AATGCTGCCCTTAGTATTTATACTTCGGCTCGAACTATTTTCAATGATTGGCAACTAAGAAAGGCGCATT ATGCAAATCCTGAGAATCGGTTGCAGGAAATAGGAGCGCAGATTTCCGAAGGCACACAATTGTTAACTGG TCCTGTAGAGTTAGAAGAAAATTCCAACGAATGTAAATGGGAAGCGCGCCCAGCCTTAGGGGCCTTTTTT GAAAAACATCCGCTGTTGTGGCATGGAGTTTCAACTCTTTTGAGAACCACGGGGGTGATTCTAATATCGA CGGCAACGATGAGTCCTCCCTTTTTGGAGCGTGTGGTTGATTTAATTAAAGATAATTTATCTTTTAGTAT GGAAGAGCAAACTATATTTTATGGAAGTTACGCCGCTTTTGAAGTGTTGACTTTGCTTTTAAATTGGGTG AATTATCATGAAATGCAAATGCCATTGAAACTTTTTCTCAAAGAAGGCGAAAATAATGCAAGACTTCGGG AGTGTAAATCCGCCTTGTTTTCGTTGCTTCACAATGATCAACCGGTCCCTGAACCAAATGTCGAAGCAAG TCGTGGGTGTTCTATTATGTAA |
| Reference |
(1) Fielden LF et al. (2017). A Farnesylated Coxiella burnetii Effector Forms a Multimeric Complex at the Mitochondrial Outer Membrane during Infection. Infect Immun. 85(5):e01046-16. [PudMed:28242621] 
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| (2) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632] |
(3) Carey KL; Newton HJ; Luhrmann A; Roy CR (2011). The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication. PLoS Pathog. 7(5):e1002056. [PudMed:21637816] 
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| experimental literature |
| in silico analysis literature |