| Effector Protein ID: 29653404 |
 T4SS name [ID] | Dot/Icm [157] |
| Gene symbol | - |
| Locus tag | CBU_0041 |
| Strain | Coxiella burnetii RSA 493 |
| Replicon | chromosome [GenBank: NC_002971] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 38088..40220 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | cirA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Overexpression of CirA in mammalian cells results in cell rounding and stress fiber disruption, a phenotype that is rescued by overexpression of wild-type or constitutively active RhoA. |
| UniProt ID | Q83FA5 |
| KEGG ID | cbu:CBU_0041 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 710 a.a. [Download] |
| >gi|29653404|ref|NP_819096.1| hypothetical protein CBU_0041 [Coxiella burnetii RSA 493] MRDGTTRVNTTGMRLKTITDVLIKLSQSSTHYDSAIFTSHKVKKFNLTTNENEPIEIWVYDDTSSSFPIL TEYLKKHLESLIAAANHIFNRNEQLKKHWHETLVYIKKALEERLKFNIDLKQARKLVRDLINEIGFFWIN QQPTMITTASQLYKGFLTKLFEAVEIAIPDYKRNHILVIQQTGDIIKCEYYERGTSRSLRSNVENALIEY RFAENTHESEKTKDFPSAHYRGKLGLCNVATCFSATFDANNETTSCKIYYRHASFPPIDLYPLYRQERKE LKNTKQRYLKKKNEMEEGGKAMVNWQNRAFKTQQCREGIKLITTRNMEMLRDLMRKNRSELELLPAERPP LIYTNISLLTVKQWMDKDFQEEQYHDTILAAERLRSRGNRENEDKFVPIMFNFGVNLQAKWQRRKSWWRP SLPKEQVFENDRAFFKFNHLVIERLQLIASKKTFSFAKTQALPHLWELNEIASSWNRYEKTLDCLANAYD AACNNYEKDPSKENIEYLQECEEKLSQAKKNLWKVADTHIAFYRKDFKQLIANRSNFSNDDSELQAILKD WKMFNSLYLRDAWHDASFSIQTSIGNLTRVVGSELSINCKSADDRTTGFCRRFEGSEEGKDASSPHVRND TDGGSIKFTGWAKTKKAKAIAKTEKKIAEAFSTHKLKKAVVAKSKIPTSHSLISSSSFWKLKAPDTSPFL TTNLPHSLSG |
| - |
| Nucleotide Sequence: 2133 bp [Download] |
| >gi|77358712|ref|NC_002971.3|:c40220-38088 Coxiella burnetii RSA 493 chromosome, complete genome ATGAGGGATGGCACTACACGCGTCAATACGACAGGAATGAGGCTTAAAACGATAACTGACGTCCTAATAA AACTAAGTCAGTCATCTACCCACTACGATTCTGCTATTTTTACCAGTCATAAAGTTAAAAAATTTAATTT AACAACCAATGAAAATGAACCGATCGAAATTTGGGTTTATGATGATACTTCCAGCTCCTTCCCTATTTTA ACTGAATATCTTAAAAAACACCTTGAATCGTTAATTGCTGCTGCCAATCACATTTTTAACCGCAATGAAC AGCTAAAAAAGCATTGGCATGAAACTTTGGTGTATATAAAAAAAGCGCTGGAAGAACGGCTGAAATTCAA CATTGATCTTAAGCAAGCGCGAAAGCTGGTTCGTGACTTAATCAATGAGATTGGGTTCTTCTGGATCAAC CAACAACCGACAATGATAACGACAGCATCGCAATTGTATAAAGGTTTTTTGACCAAACTTTTTGAAGCGG TAGAAATCGCCATTCCTGATTATAAGAGAAACCACATCCTAGTCATCCAACAAACCGGTGACATTATCAA ATGCGAGTACTATGAACGCGGGACGTCACGTTCCTTAAGGTCAAACGTAGAAAACGCATTGATAGAATAT CGATTTGCTGAAAACACTCACGAATCAGAAAAGACAAAAGATTTTCCCTCTGCTCATTACCGCGGAAAGC TAGGCCTTTGCAATGTCGCGACTTGTTTCTCCGCAACGTTTGATGCAAATAACGAAACAACTTCTTGCAA AATTTATTATCGGCATGCTTCTTTCCCGCCCATTGATTTATATCCGTTATACAGGCAAGAACGAAAAGAA CTCAAAAACACAAAGCAACGCTACTTGAAGAAAAAAAATGAGATGGAAGAAGGTGGGAAAGCGATGGTGA ATTGGCAGAATCGTGCCTTCAAGACACAACAGTGCCGTGAGGGAATAAAACTAATCACCACCCGTAATAT GGAAATGCTGCGCGATTTAATGCGAAAAAATCGAAGTGAACTAGAGTTACTGCCTGCTGAACGCCCGCCA CTTATCTACACTAATATCAGTTTATTAACGGTTAAGCAATGGATGGATAAAGATTTTCAAGAGGAGCAAT ATCACGACACTATTTTAGCGGCTGAACGACTGCGTAGCCGAGGGAACAGAGAGAATGAGGACAAATTTGT TCCCATTATGTTTAATTTTGGCGTAAATCTACAAGCAAAATGGCAACGGCGAAAATCGTGGTGGCGTCCT TCATTACCGAAAGAACAGGTTTTTGAAAACGATCGCGCGTTTTTTAAATTTAATCATTTGGTGATTGAGC GCTTACAGCTAATAGCGTCTAAGAAAACTTTTTCATTCGCCAAAACCCAAGCATTGCCTCACTTATGGGA ACTCAATGAAATTGCGTCCTCATGGAATAGGTACGAAAAAACTCTAGACTGTTTAGCTAACGCTTATGAT GCAGCTTGTAATAATTATGAAAAAGATCCTTCCAAAGAAAATATAGAATACCTTCAGGAATGTGAAGAAA AGCTTTCGCAAGCAAAGAAAAATCTTTGGAAAGTGGCGGACACCCATATCGCCTTTTATCGAAAAGACTT TAAGCAATTAATAGCTAACCGTTCAAATTTCTCTAACGACGATTCCGAATTACAAGCAATTCTGAAAGAC TGGAAAATGTTTAATAGCCTTTATTTACGCGACGCATGGCATGATGCCAGTTTTTCCATTCAAACCAGCA TTGGCAATCTAACCCGGGTGGTTGGTAGCGAACTCAGTATTAATTGCAAAAGCGCGGATGATCGCACGAC CGGATTTTGCCGTCGTTTTGAAGGAAGCGAAGAAGGCAAAGATGCATCCTCTCCTCATGTGCGCAATGAC ACGGATGGTGGATCAATAAAATTCACCGGATGGGCTAAAACAAAAAAAGCCAAAGCCATAGCGAAAACGG AAAAGAAAATAGCCGAGGCATTTTCTACCCATAAACTAAAAAAAGCGGTTGTCGCGAAATCCAAAATTCC AACCAGCCATTCACTAATTTCAAGTTCTTCCTTTTGGAAATTAAAGGCGCCCGACACTTCCCCATTTTTA ACAACAAACCTACCACATTCGTTGAGCGGATAA |
| Reference |
(1) Weber MM et al. (2016). The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection. Infect Immun. 84(9):2524-33. [PudMed:27324482] 
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| (2) McDonough JA; Newton HJ; Roy CR (2012). Coxiella burnetii Secretion Systems. Adv Exp Med Biol. 984:171-97. [PudMed:22711632] |
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(3) Chen C; Banga S; Mertens K; Weber MM; Gorbaslieva I; Tan Y; Luo ZQ; Samuel JE (2010). Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii. Proc Natl Acad Sci U S A. 107(50):21755-60. [PudMed:21098666]
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| experimental literature |