| Effector Protein ID: 29653385 |
 T4SS name [ID] | Dot/Icm [157] |
| Gene symbol | - |
| Locus tag | CBU_0021 |
| Strain | Coxiella burnetii RSA 493 |
| Replicon | chromosome [GenBank: NC_002971] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 18337..20766 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | CvpB（Coxiella vacuolar protein B）/cig2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Cig2 function promotes constitutive fusion between the CCV and autophagosomes generated by selective autophagy. Cig2-directed biogenesis of an autolysosomal vacuole is essential for the unique fusogenic properties of the CCV and for virulence in an animal model of disease. |
| UniProt ID | Q83FB9 |
| KEGG ID | cbu:CBU_0021 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 809 a.a. [Download] |
| >gi|29653385|ref|NP_819077.1| hypothetical protein CBU_0021 [Coxiella burnetii RSA 493] MSRQPSLTRQVYRDKKNQPLNKLLVFLFNLRSDNLPTGICPGPFQELAHSVPPEKRNKLIAQFGEWANFL YPKKEESAQSAPINGFISFLMEVILINPYDYNENFYKKLAEIIKIKKSKGLTWHDCLKDWLLTELTALDI TIDDLLKQNNLEQYGQFHERYDKLTSNFLSLNKSLPLSELEIYIFFSNKNRELKKLCGSLASMEKCQQNL ELIPETELAAISRQLSILDQEQCSAQIIASRQSEIPSSISSLPETSPEDWQRSIRIPIESINMSIVGAIQ VGLAHYKKKRGLTDGDIKNGKSKSYILWDNLQRDIKENPRRNYYPHLIVAFEKYANKENSAKTCILREMA SRTSTLNDSSPFKFKKNTALRYFGRLYQMIYQEKSYELERLLEPIFVLTEKIDGLENERISRESNSSENE ANLVNSLAAFNQITRKCIDIDLPRLRQNNEIISLIKDIDLMINRLNFPLSVEVINQIMTLLNGWDNSINK LKEAKEVNPTLMARLSGSRKALNEKLKEEYGKLLQNLQGNYESIKANPNFTLDELKAFEKELNKVKQLNI TELSSLGVNSNTIKDQIVKKEGQLRSYIEAYYNNHIKLKIIEMQNLLRNEKKNFEEISSTHQNTPPHVQG TLSSFSEQLKTSLDTLSSISAPSDFSSTDVIQGPLDTLRSTQTNLLGQCDLFTISLEFEEEKYNTFSIKL LHWVVEFARKIRNFLSNLFPFIEKKDKPRSPYEVTHTALNTTREAVSSLHVPQGDKQLENKLGHQSHSHA EQKISTATLNTQGMFRTKSVKETDVNKELDFEPIASFTK |
| - |
| Nucleotide Sequence: 2430 bp [Download] |
| >gi|77358712|ref|NC_002971.3|:18337-20766 Coxiella burnetii RSA 493 chromosome, complete genome ATGAGCAGACAGCCATCATTGACGAGACAAGTTTATAGGGACAAAAAAAACCAACCTTTAAACAAGCTAC TTGTTTTTCTTTTTAATCTTCGTTCTGATAATCTCCCTACCGGTATTTGTCCTGGTCCTTTCCAAGAATT AGCACATTCGGTTCCCCCTGAAAAAAGAAATAAATTAATCGCCCAATTTGGGGAGTGGGCTAATTTTCTT TACCCAAAAAAAGAGGAAAGCGCTCAGAGCGCTCCAATTAATGGTTTCATTTCTTTTTTAATGGAAGTCA TTTTAATCAATCCTTATGACTACAATGAAAATTTTTATAAAAAACTAGCAGAAATTATTAAAATTAAAAA ATCAAAGGGCTTGACCTGGCACGATTGTCTCAAAGACTGGCTTTTAACGGAACTAACTGCTCTTGATATC ACTATCGATGATTTATTAAAACAAAACAATTTGGAGCAATATGGTCAATTTCACGAGAGATATGACAAGT TGACATCAAATTTCTTAAGCCTCAATAAATCTTTACCCCTGTCGGAACTCGAAATCTATATTTTTTTCTC AAATAAAAATAGGGAGTTAAAAAAACTTTGCGGCTCGCTCGCCTCAATGGAAAAATGCCAACAGAATTTA GAATTAATTCCAGAAACTGAATTAGCAGCAATTTCTCGCCAGCTTTCAATTCTAGATCAGGAGCAATGCT CTGCTCAAATTATAGCCTCTCGCCAATCAGAAATACCTTCTTCCATTTCTAGTCTTCCCGAAACATCACC TGAGGATTGGCAAAGATCAATACGCATACCGATTGAATCTATAAACATGAGTATTGTTGGCGCTATTCAA GTAGGACTTGCTCATTATAAAAAAAAGAGAGGGCTCACTGATGGTGACATTAAAAATGGAAAAAGCAAAA GCTATATCCTTTGGGACAACTTACAAAGAGATATAAAAGAAAACCCTCGTCGTAATTATTACCCGCACCT AATTGTAGCTTTTGAAAAGTACGCAAATAAGGAAAATTCGGCAAAAACGTGCATTCTACGAGAGATGGCT TCTAGGACGTCTACACTAAACGATTCTTCTCCTTTCAAATTTAAGAAAAATACCGCTCTGCGCTATTTTG GAAGGCTATACCAAATGATTTATCAGGAAAAATCTTATGAATTGGAGAGGCTTTTGGAGCCAATTTTTGT CCTGACGGAAAAAATCGATGGATTGGAAAACGAGCGTATTTCTCGGGAATCTAATTCTTCCGAAAATGAA GCGAACCTAGTTAATTCTCTTGCTGCCTTTAACCAAATCACTCGCAAATGTATCGATATAGACCTGCCAA GGCTACGTCAAAATAACGAAATTATTTCCTTAATTAAAGACATTGATCTAATGATTAACCGATTGAATTT CCCCCTAAGCGTCGAAGTGATTAATCAAATCATGACTCTTTTAAACGGCTGGGATAATTCAATCAATAAG CTTAAAGAGGCCAAGGAAGTTAATCCAACCTTAATGGCGAGATTAAGTGGATCCAGAAAAGCTCTTAACG AAAAACTGAAAGAAGAATACGGTAAATTATTGCAAAATTTACAAGGCAATTACGAGAGCATCAAAGCTAA CCCTAATTTTACTCTCGACGAATTAAAAGCCTTTGAAAAAGAATTAAATAAAGTAAAGCAGTTAAATATA ACCGAGCTATCCTCTTTAGGAGTTAATTCAAATACAATCAAGGATCAAATAGTAAAGAAAGAAGGCCAAT TGCGTTCTTATATTGAGGCCTATTATAATAACCATATCAAACTAAAAATTATAGAAATGCAAAATCTACT TCGCAATGAGAAGAAGAATTTCGAAGAAATCTCTAGTACTCATCAAAACACTCCCCCACATGTGCAAGGA ACTCTCTCTTCTTTTAGCGAACAACTTAAGACGAGTTTGGATACTCTGTCTTCAATTTCAGCCCCATCTG ATTTTTCATCAACTGACGTGATTCAAGGTCCATTGGACACATTAAGAAGCACTCAAACTAACCTTTTAGG ACAGTGTGATCTCTTTACAATTTCTTTAGAATTTGAAGAGGAGAAATATAATACTTTCAGTATAAAATTA CTTCACTGGGTTGTCGAATTTGCACGCAAAATCCGCAATTTTCTTTCCAACCTATTTCCTTTTATCGAGA AAAAAGACAAACCTCGTTCGCCCTATGAGGTAACGCACACAGCGTTAAACACTACAAGAGAGGCCGTGTC CTCGTTACATGTTCCACAAGGTGATAAACAGCTCGAAAATAAACTTGGCCACCAGAGTCACTCTCACGCA GAACAGAAAATTTCTACAGCAACCCTGAATACCCAAGGAATGTTTAGAACAAAATCAGTTAAGGAAACAG ATGTAAATAAAGAATTGGATTTTGAGCCCATTGCTTCTTTCACTAAGTAA |
| Reference |
(1) Kohler LJ et al. (2016). Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. MBio. 7(4). pii: e01127-16. [PudMed:27435465] 
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(2) Larson CL et al. (2015). Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication. Infect Immun. 83(2):661-70. [PudMed:25422265] 
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| experimental literature |
| in silico analysis literature |