| Effector Protein ID: 296108230 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_03784 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 3030578..3031735 [-] |
| Product | acid sphingomyelinase-like phosphodiesterase |
| Effector type | Protein |
| Descripton | LegS1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | D5T978 |
| KEGG ID | lpa:lpa_03784 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Metallophos_2 [PF12850], Evalue: 5.8e-08, Aligned region: 23..265 Metallophos [PF00149], Evalue: 7.9e-05, Aligned region: 23..228 |
| Protein Sequence: 385 a.a. [Download] |
| >gi|296108230|ref|YP_003619931.1| acid sphingomyelinase-like phosphodiesterase [Legionella pneumophila 2300/99 Alcoy] MNFSIRVILLLTCFVSLAFSAPKFLTISDIHYGAENIAKDGQDTGKEFLDVTFKRFEELSQNVDFILHLG DLPTHSLFSTSKKEEYEQVVFHGLHEANPGQKPMFYITGNNDSLLGNYQPFSSDNKSPLNLALDWDGACV HCDGLIIDDTHMRKDGYYSSYVIPNNKEIILIALNSVQWTKTPVFLPKYPNQQRDAFVQLFWLEQQLKNH RAKQLLLAMHVPPGTAYNGNRFWHEIYLDRFLTLLDKYHRSYDQITILFSHSHMEEFRKIKLSDGSTIYA FSTPGISRAHHNNPGMKIFDLDKQMRVRNFTTYFTSDLYEWGNEHYQAMNIPEAIFPNCQNKTIPQCLDT LSPEQVCNNLEAGLFYGVKSTRVPYQGCIKTYQIN |
| - |
| Nucleotide Sequence: 1158 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:c3031735-3030578 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome TTGAATTTTAGTATTCGGGTAATTCTTTTATTAACATGTTTTGTTTCTTTAGCCTTTTCTGCACCAAAAT TTCTAACAATCTCTGATATTCATTATGGTGCAGAAAATATAGCAAAGGATGGGCAGGATACTGGAAAGGA GTTTTTGGATGTCACGTTCAAACGATTTGAGGAATTGTCTCAAAATGTAGATTTTATTTTACATTTGGGT GATCTGCCTACTCACTCGTTATTTTCGACATCTAAAAAAGAAGAATACGAACAAGTTGTATTTCATGGTT TGCATGAAGCGAATCCGGGTCAAAAGCCCATGTTTTATATTACAGGAAATAATGATTCCTTGCTTGGCAA TTACCAGCCATTTTCTTCAGACAATAAGTCGCCACTCAATTTGGCTCTGGATTGGGATGGTGCTTGCGTT CATTGTGATGGGTTAATTATTGATGATACTCATATGCGCAAGGATGGATATTACTCCAGTTATGTCATCC CCAATAATAAAGAGATTATTTTAATAGCACTTAATTCGGTTCAATGGACCAAGACCCCTGTTTTTTTACC AAAGTACCCTAATCAACAAAGGGATGCCTTTGTACAATTATTTTGGCTTGAACAACAATTAAAAAATCAT CGTGCAAAGCAATTGTTGTTGGCGATGCATGTTCCTCCTGGTACAGCCTATAACGGCAACCGGTTTTGGC ATGAAATTTATCTGGATAGATTTTTGACCTTATTAGACAAATATCATCGATCCTATGATCAAATCACCAT ACTGTTCTCACACTCCCATATGGAGGAATTCAGGAAAATCAAATTATCCGATGGCTCAACTATTTATGCG TTTTCTACTCCCGGAATTAGCAGGGCGCATCACAACAATCCCGGGATGAAAATTTTTGATTTAGACAAGC AAATGAGGGTCAGAAATTTTACTACTTATTTTACGTCCGATTTGTATGAGTGGGGTAATGAGCATTATCA AGCCATGAACATTCCTGAAGCCATTTTTCCAAATTGTCAAAATAAAACGATACCCCAGTGCCTGGACACC TTAAGTCCAGAGCAAGTCTGCAATAATCTGGAAGCAGGACTATTTTATGGGGTTAAAAGTACGCGTGTTC CCTATCAAGGATGCATTAAAACTTACCAGATCAATTAA |
| Reference |
(1) Gomez-Valero L et al. (2014). Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease. Genome Biol. 15(11):505. [PudMed:25370836] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |