| Effector Protein ID: 296108123 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_03628 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2917425..2921309 [+] |
| Product | LepB protein |
| Effector type | Protein |
| Descripton | LepB |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LepB is a Rab1-specific GTPase-activating protein, which facilitates the removal of Rab1 by stimulating GTP hydrolysis. |
| UniProt ID | D5T8I5 |
| KEGG ID | lpa:lpa_03628 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1294 a.a. [Download] |
| >gi|296108123|ref|YP_003619824.1| LepB protein [Legionella pneumophila 2300/99 Alcoy] MLTYQGKEIVRFKEKTGGKNKSDVDGFYEDSDGRKFFIKKPGDPRELFTELFAGLLLKEFMKRGLIDESY FPSLICADVIQFEDKSYGLIQPLVSFDELHKIIGTSYGDGSDRNTIKETFFGPGYYAGITKQNKYFGLSM ALMFSLLLGAHSVHSGNIVVLKGEGEEKSKQFGRIDWGDAFRYFAHPNNNDNLLYAYENRGWFNYKSLTK DYFLNYKKINGLFPAMAEKARQLQSKLNPELLIDIVTGALKNIPTDLIEEKTKIQLAAYMCMDSLKEATF GPEGNCKSFAIAMAALLENRLGKIAVLKDMSPLSNPEELYQSILELKYMTLPMTSSTSFSETINQWTNIL KTSDMEKFSFDSNPINLLELVKQFNLYVDELAITCEANNVWAKERIDSTPNLFALYDNSGGEAIHGHAFV PYYKESIVLRRLFTVDPNTFNLSRFAAFEGPCQLYCKEHKDSAWVKIQTLLTLGNGIINTLKIIKQAQAF GIDEAVTENLKALKEQFIAFQLAEADVKESLKAPTFAEPLPDKESEFFYPIDEKALAKMNGYQLATICLE ELNSPKPSPLIERILSNKKFWKRINSAFESGVFKGRTDDPAGKIAKIREWHQLLQISGKKTAGQIDELQK IVISLQSKIQKQTIEFEELEATLIQIKEKYQLQEKMAEQSEHEKSSAQSIIRSLNLELSQLKLQLQEQEK LQFQLKELKEKIHEQTTLSKRLGEKLQTQKKTNTHQEETIQRITKEKSLADSSLESLRKELHELAKKESS LHKTLEEKQLQVQQLEEQLAEKEKENLVLKKADKQSQHEKSLDKSAIESLTSELNQLKLELQKQEALQLQ LKSLSEQVQEQTLLVESLKEELQKQKESNTHQEETIERITKEKSLANSALESLRKEMHELTRKNEENQLK LIKQVHSLSEQLEEKQLQIREFEKQLQEKEKRVEQSEKEKASEKRTVVSLREQVSNLKLQLQQLGEVIQE KEKGSSLISQQSKQIIALQEIIEDQKRQLEELKIKIQELASANQELGKQNQSLSKENLHNKNTVEDLKKK LNELSVQLEQLHQSSSEKEQTIRKLREELIKKDSSLKQNEEMQLVQKHLQEEIDRLQKEIKQQQLNVNQL QSLIAQSKEAEKRYQQALQQKKGIYFARMERVSPIYWQIQQIEQKAKELEERRETEASTAAKTLATKLRL EIKNYLDNSEFDEKSALNSFKINAKRHIENSKETLNQHREEWKYLLANVTLGVFLLGIGYLAAILINKAT TGNYTFFSQTDSGKKLDALEKAISSTHSETLVYG |
| - |
| Nucleotide Sequence: 3885 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:2917425-2921309 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGTTAACTTATCAAGGTAAAGAAATAGTTCGATTTAAAGAAAAAACAGGTGGTAAAAATAAAAGTGATG TCGATGGTTTTTACGAAGACAGTGATGGACGAAAATTTTTTATAAAAAAACCGGGCGACCCTCGTGAGCT ATTCACGGAATTATTTGCAGGCTTGCTATTAAAAGAGTTCATGAAGCGAGGATTGATTGATGAAAGCTAT TTTCCATCATTGATTTGCGCCGATGTCATTCAATTTGAAGACAAGTCCTATGGACTGATACAGCCACTGG TTTCATTTGATGAATTACACAAAATCATTGGAACGAGCTACGGTGATGGCAGTGATCGTAATACGATAAA GGAAACCTTCTTTGGGCCAGGCTATTATGCCGGGATCACAAAACAAAATAAATATTTTGGCCTTTCTATG GCCCTTATGTTTTCTCTATTGCTGGGAGCCCATAGTGTACATAGTGGCAATATCGTTGTACTCAAAGGAG AAGGAGAAGAAAAAAGCAAACAATTTGGCCGAATCGATTGGGGAGATGCCTTCCGTTATTTCGCTCATCC AAACAATAATGACAATCTCCTTTATGCTTATGAAAACAGAGGTTGGTTTAATTATAAATCACTAACTAAA GATTATTTCCTGAACTATAAGAAGATCAATGGGCTCTTCCCTGCAATGGCTGAAAAAGCCCGGCAATTAC AATCCAAGCTAAATCCTGAATTGCTTATTGACATAGTAACTGGTGCACTCAAAAACATTCCAACCGATCT GATAGAAGAAAAAACCAAAATCCAACTTGCTGCCTACATGTGTATGGATTCATTAAAAGAGGCGACATTT GGCCCGGAGGGGAATTGCAAATCTTTTGCGATTGCCATGGCCGCATTATTAGAAAATCGTTTAGGAAAAA TTGCTGTTCTTAAAGATATGTCCCCATTGAGCAATCCTGAAGAACTGTATCAAAGTATTTTGGAATTAAA ATACATGACGCTTCCTATGACCTCTTCAACCTCTTTTTCAGAAACCATAAATCAATGGACAAACATCTTA AAAACTTCAGACATGGAAAAATTTTCGTTTGATAGTAATCCAATCAACCTACTGGAATTAGTCAAACAAT TTAATCTTTACGTTGATGAACTAGCTATCACGTGTGAAGCCAATAATGTCTGGGCAAAAGAAAGAATAGA CAGCACCCCTAATCTGTTTGCTCTCTACGATAATAGTGGTGGTGAAGCGATTCACGGACATGCCTTTGTT CCTTACTACAAAGAAAGCATTGTATTGCGCCGCCTATTTACAGTAGACCCTAATACTTTCAACTTATCTC GTTTTGCCGCTTTTGAAGGACCATGTCAACTCTATTGCAAGGAACATAAAGACTCTGCCTGGGTTAAAAT CCAAACCTTACTGACTTTAGGTAATGGAATTATTAATACGCTAAAAATAATCAAACAGGCTCAAGCATTC GGAATAGATGAGGCAGTTACAGAGAATTTAAAAGCATTGAAAGAACAATTCATTGCTTTTCAACTTGCAG AAGCTGATGTAAAGGAATCATTAAAAGCACCTACTTTTGCAGAGCCCTTGCCTGATAAGGAAAGTGAGTT TTTTTATCCCATTGATGAAAAAGCATTAGCTAAAATGAATGGATATCAACTTGCAACGATTTGTCTGGAG GAACTAAATAGCCCTAAACCGTCGCCTTTAATTGAAAGAATTCTCAGTAATAAAAAATTTTGGAAACGTA TAAACTCTGCTTTTGAAAGTGGTGTATTTAAAGGCCGCACAGATGATCCCGCCGGAAAAATAGCTAAAAT CCGTGAATGGCATCAATTATTACAGATTTCTGGTAAAAAAACTGCTGGACAAATTGATGAGCTGCAAAAG ATAGTAATTTCTCTTCAATCAAAAATTCAAAAGCAAACGATTGAATTTGAGGAGTTAGAAGCGACTTTAA TCCAAATAAAGGAAAAATATCAGTTACAAGAGAAGATGGCTGAGCAAAGTGAACATGAGAAATCTTCTGC CCAATCCATTATTCGCTCTCTGAATTTAGAACTGAGTCAGCTTAAATTACAACTGCAAGAGCAAGAAAAA TTACAGTTCCAGTTAAAAGAACTCAAAGAGAAAATACATGAACAAACGACTCTATCCAAGCGATTAGGAG AGAAGCTGCAAACGCAAAAGAAAACCAACACGCACCAGGAAGAAACCATTCAAAGAATCACCAAAGAAAA ATCATTGGCCGATTCTTCCCTTGAGTCGCTTCGAAAAGAGCTGCATGAATTGGCAAAAAAAGAAAGCTCT CTTCATAAAACGCTCGAAGAAAAACAATTACAAGTACAACAGTTAGAAGAGCAATTAGCAGAGAAAGAAA AGGAAAATCTAGTCCTGAAAAAAGCTGACAAACAAAGTCAACATGAAAAATCCCTGGATAAATCTGCTAT TGAATCTCTAACCTCAGAGCTTAATCAGCTTAAATTAGAACTGCAAAAACAAGAAGCATTACAATTGCAG TTAAAATCTTTAAGCGAACAAGTTCAAGAGCAAACATTACTTGTAGAGAGCTTGAAAGAGGAGTTACAAA AACAAAAGGAAAGCAACACACACCAGGAAGAAACTATTGAAAGAATCACTAAAGAAAAATCATTGGCCAA TTCTGCTCTTGAATCGCTTCGAAAAGAGATGCATGAATTAACTCGAAAAAACGAAGAAAATCAACTTAAA CTAATAAAACAAGTCCACTCTCTTAGCGAACAACTTGAAGAAAAACAATTACAAATTAGAGAATTTGAGA AGCAATTACAAGAAAAAGAAAAAAGAGTTGAGCAAAGTGAGAAAGAGAAAGCTTCCGAAAAACGAACTGT GGTTTCACTTAGGGAGCAAGTAAGCAATTTAAAATTGCAATTACAGCAACTTGGAGAGGTAATCCAGGAA AAGGAAAAAGGCTCCTCTTTGATAAGCCAGCAATCCAAACAAATTATTGCTCTTCAAGAGATTATAGAAG ATCAAAAAAGACAATTGGAAGAATTGAAAATAAAAATTCAGGAACTTGCATCTGCAAATCAAGAGCTTGG AAAACAAAATCAAAGTTTGAGCAAGGAAAATTTACATAATAAAAATACAGTTGAAGATCTTAAGAAAAAA TTGAATGAATTAAGTGTTCAATTGGAACAATTGCATCAATCTTCAAGTGAAAAAGAACAAACCATTAGAA AATTGAGAGAAGAACTCATTAAAAAAGATTCTTCGCTCAAACAGAATGAGGAAATGCAATTAGTTCAAAA ACATCTGCAAGAGGAAATTGATCGTTTACAAAAAGAAATTAAACAACAGCAATTAAATGTAAATCAATTA CAGTCTTTAATTGCTCAGAGTAAGGAAGCTGAAAAACGCTATCAGCAAGCTTTACAACAGAAAAAGGGAA TTTACTTTGCGCGAATGGAAAGAGTGTCTCCTATTTATTGGCAAATACAGCAAATTGAACAAAAGGCCAA AGAATTAGAGGAAAGAAGAGAAACAGAAGCATCAACAGCGGCAAAAACACTCGCAACAAAACTTCGTTTA GAGATAAAGAATTATCTCGACAATAGTGAGTTCGATGAAAAAAGTGCCTTAAACTCATTCAAAATAAATG CCAAACGGCATATAGAAAACTCGAAGGAAACGCTAAATCAACATCGCGAAGAATGGAAGTACCTGTTAGC CAATGTTACTTTAGGGGTATTCTTGCTTGGAATCGGTTATCTCGCCGCTATTTTGATTAACAAAGCAACT ACTGGCAATTATACCTTTTTCAGCCAAACTGACAGCGGGAAAAAATTGGACGCGTTGGAAAAAGCGATTT CTTCCACTCACTCCGAAACATTAGTTTATGGATAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |