| Effector Protein ID: 296107756 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_03118 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2527099..2528916 [-] |
| Product | sphinganine-1-phosphate aldolase |
| Effector type | Protein |
| Descripton | LegS2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegS2 is homologous to eukaryotic sphingosine-1-phosphate lyase and localizes to the mitochondria in host cells (Degtyar, et al. 2009) |
| UniProt ID | D5T6Q4 |
| KEGG ID | lpa:lpa_03118 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pyridoxal_deC [PF00282], Evalue: 1.5e-15, Aligned region: 188..376 Aminotran_5 [PF00266], Evalue: 9.3e-10, Aligned region: 184..487 DegT_DnrJ_EryC1 [PF01041], Evalue: 3e-05, Aligned region: 210..328 |
| Protein Sequence: 605 a.a. [Download] |
| >gi|296107756|ref|YP_003619457.1| sphinganine-1-phosphate aldolase [Legionella pneumophila 2300/99 Alcoy] MFGFISDLLTAAVSSLDELLQDTPAHQIILGTAALYFLYNQYHNPSISRWYRSRNNASMKQRIIDSAYAL AKNLPGVNQIIEKELNKELSSTREKLRIQRSGMTLREEIPEEGLSPQDILSAFDVDVEKCHFDFLSVTND SPEREFLVGRGDGKDSGALYAIHPKELTELLKEVYGATALTNPLHDKWPRINAMQAEVIRWCQNLFHGSK EGYGLLTHGGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVDKKTGAVNP NVMSSYITRNTAVMVGSAPSFMNGIHDPVSELGQLAKKKNVPFHVDACLGGFLTAFLDTSSEPMDFRVPG VTSISADLHKYGCCPKGTSVCLFSEDSPALSVYAALNWSGGLYATPGILDGSTSGARVAEVYATLSYYGK NKYQEIAKSIIRLRNAIQKELTTLVEEGAGLTSEDIYVYGNPQWSILGFRSNTCNAHFIADELEKRGWKL NLLQNPDGFHLCLTHVHTLVKGFETQFIKDLREAVIDVKNYPPGKKPSGNVKVYGAVGMMPIELQKEICK QYQKARLDFTAANHGSLGIFTPSSTEEDDGLRNRKVGEQKVQTSL |
| - |
| Nucleotide Sequence: 1818 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:c2528916-2527099 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGTTCGGTTTTATTTCAGATTTATTAACAGCAGCAGTCAGTTCTTTAGATGAATTATTACAAGATACTC CGGCACATCAAATCATATTAGGCACAGCTGCTCTTTATTTTCTTTATAATCAATACCATAACCCATCGAT TTCCAGGTGGTACCGTAGCCGCAATAACGCCAGTATGAAGCAGCGTATTATTGATAGTGCTTACGCCTTG GCAAAAAATTTACCTGGTGTGAATCAGATCATTGAGAAAGAGCTCAATAAAGAACTCTCTTCAACGAGAG AAAAATTGAGAATTCAGCGTTCCGGTATGACTCTCAGGGAGGAAATACCTGAGGAAGGGCTTTCTCCCCA AGATATTTTGAGTGCATTTGATGTGGATGTGGAAAAATGTCATTTTGATTTTTTATCCGTAACTAATGAC AGCCCTGAGAGGGAGTTTCTTGTTGGAAGAGGGGATGGTAAAGATTCAGGTGCATTATACGCTATTCACC CTAAGGAACTGACAGAGCTGCTTAAAGAAGTTTATGGGGCAACCGCTCTAACTAATCCTTTGCATGATAA ATGGCCTCGAATTAACGCAATGCAAGCGGAGGTGATTCGCTGGTGTCAAAATTTGTTTCATGGTTCAAAA GAAGGTTATGGTTTATTAACTCATGGGGGTACGACCAGCATTATTGAGGCGATGGCTGCTTATGTCATTC GCGCAAGGGCAAAAGGCATTGATTATCCTGAAATTGTCGTTCCTGAAACAGCACATGCTGCATTTAAAAA AGCAGCCGAATTAACTGGAGCAATATTAATTACGGTTCCTGTTGATAAAAAAACGGGTGCGGTGAATCCC AATGTCATGAGTTCCTATATTACCAGAAACACTGCTGTAATGGTTGGATCTGCCCCATCGTTCATGAATG GAATTCATGATCCTGTCTCTGAGTTAGGTCAATTAGCAAAGAAAAAAAATGTTCCTTTTCATGTAGATGC CTGTTTGGGTGGGTTTTTAACGGCTTTTTTAGACACTTCATCCGAGCCTATGGATTTTCGAGTGCCTGGA GTGACTTCCATTTCAGCCGATTTGCATAAATATGGCTGTTGTCCAAAAGGCACCTCTGTTTGTCTTTTTA GTGAGGATTCGCCTGCTTTGTCGGTTTATGCCGCATTAAACTGGTCAGGTGGATTGTATGCTACGCCAGG AATTCTGGATGGTTCAACCAGTGGAGCTCGTGTCGCGGAAGTCTATGCTACATTGTCTTACTATGGGAAA AATAAATATCAGGAAATCGCCAAAAGCATTATCAGATTACGCAATGCTATTCAAAAAGAATTGACGACAT TAGTGGAAGAAGGCGCTGGATTAACCAGCGAGGATATTTATGTTTATGGTAATCCTCAATGGTCCATTCT GGGTTTTAGAAGTAACACTTGCAATGCCCATTTCATTGCAGATGAATTGGAGAAGCGGGGGTGGAAGCTT AACTTGCTACAAAATCCGGATGGGTTTCATTTATGTTTGACTCATGTGCACACTTTAGTAAAAGGTTTCG AAACGCAATTTATCAAAGATTTAAGAGAGGCGGTGATTGATGTTAAAAATTATCCCCCTGGAAAGAAACC AAGTGGTAATGTCAAAGTGTATGGTGCTGTCGGTATGATGCCGATTGAGCTTCAGAAAGAAATTTGTAAA CAATATCAAAAAGCCCGCCTTGATTTTACAGCAGCCAACCACGGGAGCTTGGGGATATTTACACCTTCAT CTACAGAAGAGGACGATGGACTTAGAAACAGGAAAGTAGGGGAACAAAAAGTGCAAACCTCGCTTTGA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |