| Effector Protein ID: 296107722 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | pof1 |
| Locus tag | lpa_03071 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2459929..2460447 [+] |
| Product | F-box protein |
| Effector type | Protein |
| Descripton | AnkB/legAU13/ceg27 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkB is essential for Legionella-containing vacuole (LCV) acquisition of polyubiquitinated proteins in both macrophage and amoeba hosts |
| UniProt ID | D5T685 |
| KEGG ID | lpa:lpa_03071 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 1.1e-15, Aligned region: 62..122 Ank_2 [PF12796], Evalue: 1.1e-15, Aligned region: 63..133 Ank_4 [PF13637], Evalue: 7.9e-09, Aligned region: 61..113 F-box-like [PF12937], Evalue: 2.2e-06, Aligned region: 6..44 |
| Protein Sequence: 172 a.a. [Download] |
| >gi|296107722|ref|YP_003619423.1| F-box protein [Legionella pneumophila 2300/99 Alcoy] MKKNFFSDLPEETIINTLSFLKANTLGRIAQTCQFFNRLANDKHLELHQLRQQRIKRELWGNLMVAARSN NLEEVKKILKKGIDPAQTNSYHLNRTPLLAAIEGKAYQTANYLWRKYTFDPNFKDNYGDSPISLLKKQLA NPAFTDKEKKQIRALIRGMQEEKIAQSKCLVC |
| - |
| Nucleotide Sequence: 519 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:2459929-2460447 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGAAAAAGAATTTTTTTTCTGATCTTCCTGAGGAAACAATTATCAATACATTGAGTTTCTTAAAAGCAA ACACACTAGGTCGTATAGCTCAGACATGTCAATTTTTTAATCGCTTGGCTAATGATAAACATCTGGAACT GCATCAACTAAGACAACAACGTATAAAGCGAGAGCTATGGGGAAATCTTATGGTGGCGGCAAGAAGCAAT AACCTGGAAGAGGTCAAAAAGATTCTAAAAAAAGGAATCGATCCAGCCCAGACCAATAGCTACCACTTAA ATAGAACACCTTTACTTGCAGCTATCGAAGGAAAAGCATATCAAACTGCAAATTACCTCTGGAGAAAATA CACTTTCGATCCAAATTTTAAAGATAACTATGGTGATTCACCTATCTCTCTTCTTAAAAAGCAACTGGCA AATCCAGCCTTCACGGATAAGGAAAAAAAACAAATACGCGCCTTGATTAGGGGAATGCAAGAAGAAAAAA TAGCACAGAGCAAGTGCCTTGTTTGTTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |