| Effector Protein ID: 296107714 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_03060 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2453511..2455139 [-] |
| Product | calmodulin-dependent protein kinase |
| Effector type | Protein |
| Descripton | LegK2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegK2 is a protein kinase involved in endoplasmic reticulum recruitment and intracellular replication. (Hervet, et al. 2011) |
| UniProt ID | D5T677 |
| KEGG ID | lpa:lpa_03060 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pkinase_Tyr [PF07714], Evalue: 7.6e-07, Aligned region: 79..228 Pkinase [PF00069], Evalue: 5e-06, Aligned region: 79..227 |
| Protein Sequence: 542 a.a. [Download] |
| >gi|296107714|ref|YP_003619415.1| calmodulin-dependent protein kinase [Legionella pneumophila 2300/99 Alcoy] MVYYINLTEQPLPQDKEILTQLIKKYLLSGSSQSALFAEHCYTLNDEDGNEIEFRLSRDIYKNQRHDGIT EFLILNGPEIGRGTKGVVMQSNHAMYLMYDELVIFPKENVLKVLHRNFRNAKELIKQESVNYSILSGNSA AELVNLQGGSQGFFMQKEEGCTLEELLEDIDSLQKLTFSDKMELAISFLTELENLHNKGFVHGDLTFKNI LYNEESKRLKIIDAGEMKVADERFLAQDILIARDMVSLLFTTNETNQFNASSYWSDEPTARRILYPNLVE AKLNTILNSEYTCISALKSAIEMNYNEYLSQLNPLLQRNELSKMEREASNLHAYKDQMDKQQLFGEIRES KEVFLNMKESLPLVDQYSLKVFSDYLDNICSALNLNNDKTNEKLARAAYDFLTAQINKLFEDNSKSSQPS FESFSEDVQCFLNHINTYLINNPTACSNSIVSTIKLLKQLDNKRSFNPEQSLKNFCGYKEIMIQLLLKPF ETPVAEMASVPATVSDFIEKQSDTKRRLQEMKSSANQDKQPIFTPSLMRGPS |
| - |
| Nucleotide Sequence: 1629 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:c2455139-2453511 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGGTTTATTACATAAATTTGACGGAACAACCTTTACCTCAAGATAAAGAAATTTTAACGCAGTTAATTA AGAAATATTTATTGTCTGGTTCCAGTCAGTCCGCATTGTTTGCTGAACATTGTTACACGCTAAACGATGA AGATGGAAATGAAATAGAGTTCCGCTTGAGTCGTGATATTTACAAGAATCAACGTCATGATGGTATTACT GAGTTTTTAATTTTAAATGGTCCAGAGATAGGGAGAGGAACCAAAGGCGTAGTGATGCAGAGTAATCATG CTATGTATTTAATGTATGATGAATTGGTAATTTTCCCTAAAGAGAATGTACTGAAGGTTTTACATCGAAA TTTTAGAAATGCCAAGGAGCTAATAAAACAGGAGTCTGTCAATTATTCGATTTTATCAGGTAATTCAGCT GCAGAATTAGTCAATTTGCAAGGAGGAAGCCAAGGTTTTTTTATGCAAAAAGAAGAAGGGTGTACTTTGG AAGAGCTTCTTGAGGATATAGACTCACTTCAAAAATTGACATTTTCAGACAAAATGGAGTTAGCTATTTC ATTTTTAACTGAGTTAGAAAATCTGCATAACAAAGGCTTTGTCCATGGCGATTTAACTTTCAAGAATATT TTATATAACGAAGAGAGTAAGCGATTAAAAATCATTGATGCAGGAGAGATGAAAGTAGCAGATGAACGCT TTTTAGCGCAGGATATTTTAATTGCCAGGGATATGGTATCTCTCTTGTTTACAACTAATGAAACAAATCA ATTTAATGCATCAAGTTATTGGTCTGATGAACCCACAGCCAGACGAATACTTTACCCAAACCTGGTCGAA GCTAAGTTAAATACAATTTTGAACAGTGAATACACTTGTATTTCAGCTTTAAAGTCGGCCATTGAAATGA ATTACAATGAATATCTAAGCCAACTGAATCCTCTATTGCAAAGAAATGAGCTTTCAAAAATGGAAAGAGA GGCTTCGAATTTGCATGCCTACAAGGATCAAATGGATAAGCAACAACTCTTTGGGGAAATTCGAGAATCT AAAGAAGTTTTTTTAAATATGAAAGAAAGTTTGCCTCTTGTAGATCAATACAGTCTTAAAGTATTTTCTG ATTATCTGGATAATATCTGCTCCGCATTAAATTTAAATAATGATAAAACCAATGAAAAGTTAGCTAGAGC TGCCTATGATTTTCTAACAGCACAAATCAATAAATTATTTGAGGATAATTCGAAAAGCTCACAACCAAGT TTCGAAAGTTTCTCAGAAGATGTTCAGTGTTTTTTAAATCATATTAATACCTATTTAATAAATAATCCTA CCGCCTGCTCTAATTCCATCGTTTCCACCATTAAGCTATTGAAACAGTTGGATAATAAAAGGAGTTTTAA CCCGGAGCAATCTCTTAAGAATTTCTGTGGATATAAAGAAATTATGATTCAATTGTTATTAAAACCATTT GAAACACCAGTGGCTGAAATGGCTAGTGTACCTGCTACAGTATCTGATTTCATTGAAAAACAATCTGACA CCAAAAGAAGACTTCAGGAAATGAAATCTTCTGCAAATCAAGATAAGCAACCTATATTTACCCCTTCATT GATGCGAGGCCCAAGCTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |